MAPKAPK3 and TCF3

Number of citations of the paper that reports this interaction (PMID 10781029)
13

Data Source:
HPRD (in vivo, two hybrid)

		MAPKAPK3	TCF3
Gene Name		mitogen-activated protein kinase-activated protein kinase 3	transcription factor 3
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Membrane	Nuclear Nucleosome Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Protein Complex RNA Polymerase II Transcription Factor Complex
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Enhancer Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity Repressing Transcription Factor Binding Vitamin D Response Element Binding E-box Binding
	Biological Process	Activation Of MAPK Activity Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Response To Stress Signal Transduction Ras Protein Signal Transduction Peptidyl-serine Phosphorylation Response To Lipopolysaccharide Response To Cytokine Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Macropinocytosis Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade	Negative Regulation Of Transcription From RNA Polymerase II Promoter Natural Killer Cell Differentiation B Cell Lineage Commitment Transcription, DNA-templated Regulation Of Transcription, DNA-templated B Cell Differentiation Positive Regulation Of B Cell Proliferation Response To Lipopolysaccharide T Cell Differentiation In Thymus Immunoglobulin V(D)J Recombination Response To Drug Muscle Cell Differentiation Histone H3 Acetylation Histone H4 Acetylation Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Development Peyer's Patch Development Protein Stabilization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Muscle Cell Differentiation Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Signalling to ERKs Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence VEGFA-VEGFR2 Pathway Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade p38MAPK events MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Innate Immune System activated TAK1 mediates p38 MAPK activation Signalling by NGF TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by VEGF Oxidative Stress Induced Senescence Signalling to RAS Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade	CDO in myogenesis Myogenesis
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: APP COPS6 EEF2 EEF2K EZH2 HSPB1 IGHM MAPK11 MAPK13 MAPK14 NEDD4 NEDD4L RAB2A SMS SUMO3 TCF3	62 interactors: AEBP1 ASCL3 BHLHA15 CALM1 CALM3 CBFA2T3 CREBBP CTNNB1 DAXX ELK3 EP300 FERD3L HAND1 HAND2 HOXA1 ID1 ID2 ID3 KAT2A KAT2B LMX1A LMX1B LYL1 MAPK1 MAPK3 MAPKAPK2 MAPKAPK3 MAX MDFI MEN1 MSC MYF5 MYF6 MYOD1 MYOG NEDD9 NHLH1 PDX1 PRKACA PSMD4 PSMD9 RALGAPA1 RPL37 RUFY1 RUNX1T1 SKP2 SRF SUPT3H TADA2A TAL1 TAL2 TCAF1 TCF12 TCF21 TCF4 TFPT TLE1 TRRAP TWIST1 UBE2I USF1 VDR
Entrez ID		7867	6929
HPRD ID		03678	00918
Ensembl ID		ENSG00000114738	ENSG00000071564
Uniprot IDs		Q16644	P15923 Q2TB39
PDB IDs		3FHR 3FXW 3R1N 3SHE	1HLH 2YPA 2YPB 3U5V
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Metabolic Process Cellular Protein Modification Process Regulation Of Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Regulation Of Muscle Cell Differentiation Posttranscriptional Regulation Of Gene Expression Ras Protein Signal Transduction Positive Regulation Of Metabolic Process Gene Expression Regulation Of Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Protein Metabolic Process Peptidyl-amino Acid Modification Negative Regulation Of Sodium Ion Transport Positive Regulation Of Muscle Cell Differentiation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Regulation Of Protein Kinase Activity Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cellular Response To Organic Substance Response To Stress Regulation Of Kinase Activity Regulation Of Phosphorylation Skeletal Muscle Tissue Regeneration Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Immune System Process Platelet Activation Regulation Of Potassium Ion Transmembrane Transport Regulation Of Gene Expression Protein Monoubiquitination Regulation Of Cell Differentiation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Signaling Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Neurotrophin Signaling Pathway MAPK Cascade	RNA Biosynthetic Process Transcription, DNA-templated Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Organ Development Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process System Development Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Cellular Process Anatomical Structure Development Multicellular Organismal Development Developmental Process Embryo Development Tissue Development Organ Morphogenesis Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Binding Embryonic Morphogenesis Cell Differentiation Anatomical Structure Morphogenesis Embryonic Organ Development
Tagcloud ?		ca1 ca3 carries corresponds dentate depolarization differential display forskolin frame gyrus identical intron kainic library message mitogen ortholog pc12 pheochromocytoma preceded predicted proline rat reading repressed seizures terminus	advantageous characterize chimpanzee crebbp eleven ep300 evolution fgf2 germ gorilla hdac3 macaque macaques mapped microarrays orangutan organs partners primate prkd3 profiled profiling proteomics regard runx1 runx2 satb2 testis yap1
Tagcloud (Difference) ?		ca1 ca3 carries corresponds dentate depolarization differential display forskolin frame gyrus identical intron kainic library message mitogen ortholog pc12 pheochromocytoma preceded predicted proline rat reading repressed seizures terminus	advantageous characterize chimpanzee crebbp eleven ep300 evolution fgf2 germ gorilla hdac3 macaque macaques mapped microarrays orangutan organs partners primate prkd3 profiled profiling proteomics regard runx1 runx2 satb2 testis yap1
Tagcloud (Intersection) ?