MAPKAPK3 and SMS

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		MAPKAPK3	SMS
Description		MAPK activated protein kinase 3	spermine synthase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cytosol Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity MAP Kinase Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity	Transferase Activity Spermine Synthase Activity
	Biological Process	MAPK Cascade Toll-like Receptor Signaling Pathway Signal Transduction Response To Lipopolysaccharide Response To Cytokine Intracellular Signal Transduction Macropinocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway	Methionine Metabolic Process Polyamine Metabolic Process Polyamine Biosynthetic Process Spermine Biosynthetic Process Spermine Metabolic Process
Pathways		p38MAPK events Oxidative Stress Induced Senescence VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation	Metabolism of polyamines
Drugs		2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE	Spermine
Diseases			Snyder-Robinson syndrome
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cortical surface area (MOSTest) ( 32665545) Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) High light scatter reticulocyte count ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		21 interacting genes: APP ATF1 BECN1 COPS6 EEF2 EEF2K EZH2 HSPB1 IGHM LINC02582 MAPK13 MAPK14 NEDD4 NEDD4L RAB2A RCSD1 SMS SRPK2 SUMO3 TCF3 THAP12	6 interacting genes: CEBPA EZH2 MAPK6 MAPK8IP2 MAPKAPK3 RPS6KA3
Entrez ID		7867	6611
HPRD ID		03678	02115
Ensembl ID		ENSG00000114738	ENSG00000102172
Uniprot IDs		Q16644	P52788
PDB IDs		3FHR 3FXW 3R1N 3SHE 7NRB	3C6K 3C6M
Enriched GO Terms of Interacting Partners?		Response To Growth Factor Cellular Response To Growth Factor Stimulus Receptor Catabolic Process Response To Hydrogen Peroxide Regulation Of Dendrite Development Response To Nerve Growth Factor Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Potassium Ion Export Across Plasma Membrane Receptor Metabolic Process Regulation Of Synapse Organization Response To Metal Ion Positive Regulation Of Cell Cycle Response To Reactive Oxygen Species Sodium Channel Inhibitor Activity Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Dendrite Morphogenesis Potassium Channel Inhibitor Activity Cellular Response To Hydrogen Peroxide Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Plasma Membrane Bounded Cell Projection Organization Response To Stress Negative Regulation Of Sodium Ion Transport Regulation Of Cell Projection Organization Regulation Of Neuron Projection Development Cellular Response To UV MAP Kinase Activity Response To Lead Ion Regulation Of Cell Cycle Positive Regulation Of Cellular Component Organization Positive Regulation Of Metabolic Process Protein Metabolic Process Regulation Of Protein Metabolic Process Response To Other Organism Cellular Response To Copper Ion Cellular Response To Light Stimulus Stress-activated MAPK Cascade Cellular Response To Reactive Oxygen Species Cellular Response To Chemical Stress Negative Regulation Of Potassium Ion Transmembrane Transport Intracellular Transport Cytosol Positive Regulation Of Transport Vesicle-mediated Transport Cellular Response To Stress P38MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Viral Budding Lysosomal Transport Intracellular Signaling Cassette Extracellular Exosome	Negative Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of Transcription Elongation By RNA Polymerase II Intracellular Signaling Cassette Response To Lipid Intracellular Signal Transduction Animal Organ Regeneration MAPK Cascade Toll-like Receptor Signaling Pathway RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Hepatocyte Homeostasis Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity U6 2'-O-snRNA Methylation Nucleoplasm Chromatin DNA Binding Response To Vitamin B2 Positive Regulation Of Defense Response Liver Development C/EBP Complex Cellular Response To Trichostatin A Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Septin Cytoskeleton Protein Kinase Binding Protein Kinase Activity CHOP-C/EBP Complex Positive Regulation Of Developmental Process Regeneration Histone H3K27 Trimethyltransferase Activity Response To Tetrachloromethane Box C/D Sno(s)RNA 3'-end Processing Kinase Activity White Fat Cell Proliferation Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Positive Regulation Of SnRNA Transcription By RNA Polymerase II 7SK SnRNP Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Histone H3K27 Methyltransferase Activity Innate Immune Response-activating Signaling Pathway Ribosomal Protein S6 Kinase Activity Calcium-dependent Protein Serine/threonine Kinase Activity SnRNA Modification Response To Phenylpropanoid Protein-containing Complex Pronucleus Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Transferase Activity Methylation
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