MAPKAPK3 and HSPB1

Number of citations of the paper that reports this interaction (PMID 8774846)
32

Data Source:
HPRD (in vitro)

		MAPKAPK3	HSPB1
Gene Name		mitogen-activated protein kinase-activated protein kinase 3	heat shock 27kDa protein 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Membrane	Proteasome Complex Extracellular Space Nucleus Cytoplasm Spindle Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Z Disc Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding	Protein Kinase C Binding Protein Binding Protein Kinase C Inhibitor Activity Protein Kinase Binding Identical Protein Binding Ubiquitin Binding Poly(A) RNA Binding
	Biological Process	Activation Of MAPK Activity Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Response To Stress Signal Transduction Ras Protein Signal Transduction Peptidyl-serine Phosphorylation Response To Lipopolysaccharide Response To Cytokine Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Macropinocytosis Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade	Retina Homeostasis Regulation Of Translational Initiation Negative Regulation Of Protein Kinase Activity Movement Of Cell Or Subcellular Component Response To Unfolded Protein Response To Virus Gene Expression Positive Regulation Of Interleukin-1 Beta Production Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Platelet Aggregation Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endothelial Cell Chemotaxis
Pathways		Signalling to ERKs Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence VEGFA-VEGFR2 Pathway Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade p38MAPK events MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Innate Immune System activated TAK1 mediates p38 MAPK activation Signalling by NGF TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by VEGF Oxidative Stress Induced Senescence Signalling to RAS Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade	Regulation of mRNA stability by proteins that bind AU-rich elements Signaling by VEGF AUF1 (hnRNP D0) destabilizes mRNA VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: APP COPS6 EEF2 EEF2K EZH2 HSPB1 IGHM MAPK11 MAPK13 MAPK14 NEDD4 NEDD4L RAB2A SMS SUMO3 TCF3	40 interactors: ACTC1 AKT1 CRYAA CRYAB CRYBB2 CRYGC CS CYCS DAXX EFTUD2 EIF4G1 HNRNPD HSPB8 IGSF21 INS LBP LRIF1 MAPKAPK2 MAPKAPK3 MAPKAPK5 MED31 MFAP1 NFKBIA PLG POP7 PPA1 PPM1A PRKD1 PRPF19 RBM48 RPS6KA5 SERTAD1 SF3B3 SMARCD1 SNCA TGFB1I1 TGM1 TP53 UCHL5 WDR83
Entrez ID		7867	3315
HPRD ID		03678	09076
Ensembl ID		ENSG00000114738	ENSG00000106211
Uniprot IDs		Q16644	P04792
PDB IDs		3FHR 3FXW 3R1N 3SHE	3Q9P 3Q9Q
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Metabolic Process Cellular Protein Modification Process Regulation Of Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Regulation Of Muscle Cell Differentiation Posttranscriptional Regulation Of Gene Expression Ras Protein Signal Transduction Positive Regulation Of Metabolic Process Gene Expression Regulation Of Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Protein Metabolic Process Peptidyl-amino Acid Modification Negative Regulation Of Sodium Ion Transport Positive Regulation Of Muscle Cell Differentiation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Regulation Of Protein Kinase Activity Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cellular Response To Organic Substance Response To Stress Regulation Of Kinase Activity Regulation Of Phosphorylation Skeletal Muscle Tissue Regeneration Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Immune System Process Platelet Activation Regulation Of Potassium Ion Transmembrane Transport Regulation Of Gene Expression Protein Monoubiquitination Regulation Of Cell Differentiation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Signaling Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Neurotrophin Signaling Pathway MAPK Cascade	Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor MAPK Cascade Positive Regulation Of Protein Phosphorylation Negative Regulation Of Transport Positive Regulation Of Metabolic Process Toll-like Receptor 4 Signaling Pathway Signal Transduction By Phosphorylation Cellular Response To Stress Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Response To Stress Peptidyl-serine Phosphorylation Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Innate Immune Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Signal Transduction Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Response To Organic Substance Intracellular Signal Transduction Activation Of Innate Immune Response Cellular Response To Organic Substance TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Phosphorylation Regulation Of Reactive Oxygen Species Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Intracellular Transport MyD88-dependent Toll-like Receptor Signaling Pathway Gene Expression
Tagcloud ?		ca1 ca3 carries corresponds dentate depolarization differential display forskolin frame gyrus identical intron kainic library message mitogen ortholog pc12 pheochromocytoma preceded predicted proline rat reading repressed seizures terminus	adenocarcinomas adenoma antiapoptotic bax bcl2 cytotoxic elisa exists follows fresh gland glands glandular hsp27 immunosorbent messenger neoplasm neoplasms oesophageal origin pa pleomorphic positively ribonucleic salivary stresses tolerance tumours whose
Tagcloud (Difference) ?		ca1 ca3 carries corresponds dentate depolarization differential display forskolin frame gyrus identical intron kainic library message mitogen ortholog pc12 pheochromocytoma preceded predicted proline rat reading repressed seizures terminus	adenocarcinomas adenoma antiapoptotic bax bcl2 cytotoxic elisa exists follows fresh gland glands glandular hsp27 immunosorbent messenger neoplasm neoplasms oesophageal origin pa pleomorphic positively ribonucleic salivary stresses tolerance tumours whose
Tagcloud (Intersection) ?