PTCH2

Gene Name		patched 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane
	Molecular Function	Smoothened Binding Hedgehog Receptor Activity Hedgehog Family Protein Binding
	Biological Process	Signal Transduction Epidermis Development Hair Cycle Negative Regulation Of Smoothened Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS
Protein-protein Interactions		4 interactors: DHH IHH SHH SMO
Entrez ID		8643
HPRD ID		04722
Ensembl ID		ENSG00000117425
Uniprot IDs		Q9Y6C5
PDB IDs
Enriched GO Terms of Interacting Partners?		Intein-mediated Protein Splicing Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Smoothened Signaling Pathway Heart Looping Determination Of Heart Left/right Asymmetry Embryonic Heart Tube Morphogenesis Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Hh Target Transcription Factor Activity Embryonic Heart Tube Development Determination Of Left/right Asymmetry In Lateral Mesoderm Signal Transduction Downstream Of Smoothened Regulation Of Smoothened Signaling Pathway Cell Fate Specification Pancreas Development Somite Development Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Ventral Midline Development Determination Of Left/right Symmetry Regulation Of Stem Cell Proliferation Smoothened Signaling Pathway Determination Of Bilateral Symmetry Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Involved In Regulation Of Granule Cell Precursor Cell Proliferation Epithelial-mesenchymal Cell Signaling Digestive Tract Development Osteoblast Differentiation Digestive System Development Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Lateral Mesoderm Development Thalamus Development Negative Regulation Of Alpha-beta T Cell Differentiation Cell-cell Signaling Positive Regulation Of T Cell Differentiation In Thymus Heart Morphogenesis Negative Regulation Of Alpha-beta T Cell Activation Ossification Regulation Of Epithelial Cell Proliferation Positive Regulation Of Neuroblast Proliferation Embryonic Digestive Tract Morphogenesis Cell Fate Commitment Spinal Cord Dorsal/ventral Patterning Embryonic Organ Morphogenesis Regulation Of T Cell Differentiation In Thymus Spinal Cord Patterning Muscle Tissue Development Hair Follicle Morphogenesis Negative Regulation Of T Cell Differentiation Dorsal/ventral Neural Tube Patterning Positive Regulation Of Kidney Development
Tagcloud ?		calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9