RELB and MALT1

Number of citations of the paper that reports this interaction (PubMedID 31961340)
87

Data Source:
BioGRID (enzymatic study)

		RELB	MALT1
Description		RELB proto-oncogene, NF-kB subunit	MALT1 paracaspase
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Transcription Repressor Complex Protein-containing Complex Synapse NF-kappaB Complex	Fibrillar Center Polkadots Nucleus Cytoplasm Cytosol CBM Complex Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Identical Protein Binding	Protease Binding Endopeptidase Activity Cysteine-type Endopeptidase Activity Ubiquitin-protein Transferase Activity Protein Binding Peptidase Activity Hydrolase Activity Kinase Activator Activity Small Molecule Binding Identical Protein Binding Endopeptidase Activator Activity
	Biological Process	Regulation Of DNA-templated Transcription Inflammatory Response Canonical NF-kappaB Signal Transduction Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Antigen Processing And Presentation Lymphocyte Differentiation Negative Regulation Of Interferon-beta Production Circadian Regulation Of Gene Expression Response To Cytokine Non-canonical NF-kappaB Signal Transduction T-helper 1 Type Immune Response Myeloid Dendritic Cell Differentiation T-helper 1 Cell Differentiation Innate Immune Response Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Cellular Response To Osmotic Stress	B-1 B Cell Differentiation Immune System Process Positive Regulation Of Immune Effector Process Positive Regulation Of T Cell Cytokine Production Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Proteolysis Defense Response Response To Fungus Regulation Of Signal Transduction Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-2 Production T Cell Proliferation B Cell Activation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Nuclear Export Positive Regulation Of Multicellular Organismal Process Proteolysis Involved In Protein Catabolic Process Cellular Response To Lipopolysaccharide Positive Regulation Of T-helper 17 Cell Differentiation
Pathways		Dectin-1 mediated noncanonical NF-kB signaling CD209 (DC-SIGN) signaling NIK-->noncanonical NF-kB signaling	Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling CLEC7A/inflammasome pathway
Drugs
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebral amyloid angiopathy in Alzheimer’s disease ( 34020725) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Red cell distribution width ( 32888494) Triglyceride levels ( 32154731)	Metabolite levels ( 23823483) Multiple sclerosis ( 21833088 31604244)
Interacting Genes		26 interacting genes: BCL7A BUD31 CDK1 CTSL DPF2 EHMT2 EZH2 GSK3B HDAC6 KPNA2 KPNA6 MALT1 MAP1LC3A MT1M MTAP NFKB1 NFKB2 RELA SIN3A SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCE1 UQCRFS1 USP11	15 interacting genes: BCL10 CARM1 FEM1A FEM1C KDM1A PRMT6 RELB SQSTM1 SUV39H1 TRAF2 TRAF6 UBC UBE2N UBE2V2 USP2
Entrez ID		5971	10892
HPRD ID		06886	06892
Ensembl ID		ENSG00000104856	ENSG00000172175
Uniprot IDs		D6R992 Q01201	A8K5S1 Q9UDY8
PDB IDs		8G8R	2G7R 3BFO 3K0W 3UO8 3UOA 3V4O 3V55 4I1P 4I1R 6F7I 6GK2 6H4A 6YN8 6YN9 7A41 7AK0 7AK1 7PAV 7PAW 8CZO 8J5I 8V4X
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleotide-excision Repair SWI/SNF Complex NBAF Complex Regulation Of G0 To G1 Transition Positive Regulation Of Stem Cell Population Maintenance Regulation Of Sister Chromatid Segregation NpBAF Complex Regulation Of Stem Cell Population Maintenance Regulation Of Chromosome Segregation RSC-type Complex Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Chromatin Remodeling Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Developmental Process Chromatin Chromatin Organization Regulation Of G1/S Transition Of Mitotic Cell Cycle Nucleosome Disassembly Positive Regulation Of Double-strand Break Repair Protein-DNA Complex Disassembly Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Cell Differentiation Nucleoplasm BBAF Complex Regulation Of DNA Metabolic Process Positive Regulation Of DNA Repair Positive Regulation Of Cell Differentiation Protein-containing Complex Disassembly Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Regulation Of Double-strand Break Repair Regulation Of Chromosome Organization Nucleosomal DNA Binding Brahma Complex Positive Regulation Of DNA Metabolic Process Positive Regulation Of Myoblast Differentiation Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of T Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA Repair Cellular Response To Hydrogen Peroxide Positive Regulation Of Lymphocyte Differentiation Regulation Of Cellular Response To Stress Regulation Of Cell Cycle Process Regulation Of Multicellular Organismal Process	Protein K63-linked Ubiquitination Non-canonical NF-kappaB Signal Transduction Post-translational Protein Modification Regulation Of Protein Ubiquitination Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Protein Modification By Small Protein Conjugation Nucleoplasm Positive Regulation Of Post-translational Protein Modification Ubiquitin Protein Ligase Binding Protein Modification Process Positive Regulation Of Protein Modification Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Protein Modification Process Histone H3R2 Methyltransferase Activity UBC13-MMS2 Complex Histone Arginine N-methyltransferase Activity Ubiquitin Ligase Complex Positive Regulation Of DNA-binding Transcription Factor Activity Histone Methyltransferase Activity Protein Polyubiquitination Ubiquitin Conjugating Enzyme Complex Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Macromolecule Metabolic Process Protein-arginine Omega-N Asymmetric Methyltransferase Activity Regulation Of DNA-binding Transcription Factor Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein K63-linked Ubiquitination Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein-arginine N-methyltransferase Activity Regulation Of RNA Metabolic Process Cellular Response To Stress T-helper 1 Type Immune Response CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Protein-macromolecule Adaptor Activity Protein-containing Complex CD40 Receptor Complex Protein Kinase B Binding Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Signaling Adaptor Activity Regulation Of DNA Repair Positive Regulation Of JUN Kinase Activity
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