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RELB and MT1M
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
RELB
MT1M
Description
RELB proto-oncogene, NF-kB subunit
metallothionein 1M
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Transcription Repressor Complex
Protein-containing Complex
Synapse
NF-kappaB Complex
Nucleus
Cytoplasm
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein Kinase Binding
Identical Protein Binding
Protein Binding
Zinc Ion Binding
Metal Ion Binding
Biological Process
Regulation Of DNA-templated Transcription
Inflammatory Response
Canonical NF-kappaB Signal Transduction
Regulation Of Gene Expression
Negative Regulation Of Macromolecule Biosynthetic Process
Antigen Processing And Presentation
Lymphocyte Differentiation
Negative Regulation Of Interferon-beta Production
Circadian Regulation Of Gene Expression
Response To Cytokine
Non-canonical NF-kappaB Signal Transduction
T-helper 1 Type Immune Response
Myeloid Dendritic Cell Differentiation
T-helper 1 Cell Differentiation
Innate Immune Response
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Cellular Response To Osmotic Stress
Intracellular Zinc Ion Homeostasis
Detoxification Of Copper Ion
Negative Regulation Of Growth
Cellular Response To Cadmium Ion
Cellular Response To Copper Ion
Cellular Response To Zinc Ion
Pathways
Dectin-1 mediated noncanonical NF-kB signaling
CD209 (DC-SIGN) signaling
NIK-->noncanonical NF-kB signaling
Metallothioneins bind metals
Drugs
Silver
Diseases
GWAS
Alzheimer's disease or family history of Alzheimer's disease (
30617256
)
Alzheimer's disease or HDL levels (pleiotropy) (
30805717
)
Body mass index (
26426971
)
Body mass index (age>50) (
26426971
)
Body mass index x age interaction (
26426971
)
Body mass index x sex x age interaction (4df test) (
26426971
)
Carotid intima media thickness (maximum) (
31801372
)
Carotid intima media thickness (mean) (
31801372
)
Cerebral amyloid angiopathy in Alzheimer’s disease (
34020725
)
Cerebrospinal AB1-42 levels in mild cognitive impairment (
29274321
)
Cerebrospinal AB1-42 levels in normal cognition (
29274321
)
Cerebrospinal fluid AB1-42 levels (
29274321
)
Cerebrospinal fluid p-tau levels (
29274321
)
Cerebrospinal fluid p-tau levels in mild cognitive impairment (
29274321
)
Cerebrospinal fluid t-tau levels (
29274321
)
Cerebrospinal fluid t-tau levels in mild cognitive impairment (
29274321
)
Hippocampal volume (
29274321
)
Hippocampal volume in Alzheimer's disease dementia (
29274321
)
Logical memory (delayed recall) (
29274321
)
Logical memory (immediate recall) (
29274321
)
Red cell distribution width (
32888494
)
Triglyceride levels (
32154731
)
Interacting Genes
26 interacting genes:
BCL7A
BUD31
CDK1
CTSL
DPF2
EHMT2
EZH2
GSK3B
HDAC6
KPNA2
KPNA6
MALT1
MAP1LC3A
MT1M
MTAP
NFKB1
NFKB2
RELA
SIN3A
SMARCA4
SMARCB1
SMARCC1
SMARCC2
SMARCE1
UQCRFS1
USP11
8 interacting genes:
CYSRT1
DDIT4L
KRTAP17-1
KRTAP5-1
KRTAP5-9
RELB
SMCP
UFL1
Entrez ID
5971
4499
HPRD ID
06886
01129
Ensembl ID
ENSG00000104856
ENSG00000205364
Uniprot IDs
D6R992
Q01201
Q8N339
PDB IDs
8G8R
Enriched GO Terms of Interacting Partners
?
Regulation Of Nucleotide-excision Repair
SWI/SNF Complex
NBAF Complex
Regulation Of G0 To G1 Transition
Positive Regulation Of Stem Cell Population Maintenance
Regulation Of Sister Chromatid Segregation
NpBAF Complex
Regulation Of Stem Cell Population Maintenance
Regulation Of Chromosome Segregation
RSC-type Complex
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle
Chromatin Remodeling
Regulation Of Mitotic Metaphase/anaphase Transition
Positive Regulation Of Developmental Process
Chromatin
Chromatin Organization
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Nucleosome Disassembly
Positive Regulation Of Double-strand Break Repair
Protein-DNA Complex Disassembly
Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Differentiation
Nucleoplasm
BBAF Complex
Regulation Of DNA Metabolic Process
Positive Regulation Of DNA Repair
Positive Regulation Of Cell Differentiation
Protein-containing Complex Disassembly
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Multicellular Organismal Process
Regulation Of Double-strand Break Repair
Regulation Of Chromosome Organization
Nucleosomal DNA Binding
Brahma Complex
Positive Regulation Of DNA Metabolic Process
Positive Regulation Of Myoblast Differentiation
Regulation Of RNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of T Cell Differentiation
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA Repair
Cellular Response To Hydrogen Peroxide
Positive Regulation Of Lymphocyte Differentiation
Regulation Of Cellular Response To Stress
Regulation Of Cell Cycle Process
Regulation Of Multicellular Organismal Process
Intermediate Filament
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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