RELB and EHMT2

Number of citations of the paper that reports this interaction (PMID 19690169)
28

Data Source:
BioGRID (pull down)

		RELB	EHMT2
Gene Name		v-rel avian reticuloendotheliosis viral oncogene homolog B	euchromatic histone-lysine N-methyltransferase 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol I-kappaB/NF-kappaB Complex	Nuclear Chromatin Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle Intermediate Filament Cytoskeleton
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding	P53 Binding Protein Binding Zinc Ion Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K9 Specific) Histone Methyltransferase Activity (H3-K27 Specific) C2H2 Zinc Finger Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Antigen Processing And Presentation Circadian Regulation Of Gene Expression Response To Cytokine NIK/NF-kappaB Signaling Myeloid Dendritic Cell Differentiation T-helper 1 Cell Differentiation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Osmotic Stress	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of DNA Replication DNA Methylation Chromatin Organization Histone Methylation Peptidyl-lysine Dimethylation Histone Lysine Methylation Histone H3-K9 Methylation Histone H3-K27 Methylation
Pathways			Chromatin modifying enzymes Chromatin organization RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation PKMTs methylate histone lysines RNA Polymerase I Promoter Clearance Cellular Senescence Senescence-Associated Secretory Phenotype (SASP)
Drugs
Diseases
GWAS			Chronic hepatitis B infection ( 23760081) Economic and political preferences (environmentalism) ( 22566634) Epstein-Barr virus immune response (EBNA-1) ( 23326239)
Protein-Protein Interactions		25 interactors: BCL7A BUD31 CDK1 CTSL DPF2 EHMT2 EZH2 GSK3B HDAC6 KPNA2 KPNA6 MALT1 MT1M MTAP NFKB1 NFKB2 RELA SIN3A SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCE1 UQCRFS1 USP11	42 interactors: C10orf12 CACNA1A CBX1 CCDC33 CHCHD2 CUX1 DNMT3A E4F1 ESR1 FAM161A H3F3B HGS HIST1H1A HIST1H1B HIST1H3A HIST2H3A HIST2H3C HIST3H3 ITGB5 KLF12 KLF3 KLF6 LIMS1 LMO2 LNX1 MX2 NAA10 NAPRT PLOD3 PRRC2B PSMA1 RD3 RELB RERE RUVBL2 THAP7 TP53 WIZ XAGE2 ZBTB38 ZNF512B ZNF785
Entrez ID		5971	10919
HPRD ID		06886	06854
Ensembl ID		ENSG00000104856	ENSG00000204371
Uniprot IDs		D6R992 Q01201	A2ABF8 A2ABF9 Q96KQ7
PDB IDs			2O8J 3DM1 3K5K 3RJW
Enriched GO Terms of Interacting Partners?		Nucleosome Disassembly Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Modification Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromatin Organization Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated ATP-dependent Chromatin Remodeling Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Activation Of Innate Immune Response Positive Regulation Of Macromolecule Biosynthetic Process Response To Organic Substance Negative Regulation Of Gene Expression Chromosome Organization Positive Regulation Of Innate Immune Response Positive Regulation Of Cellular Metabolic Process Protein Complex Disassembly Regulation Of Gene Expression, Epigenetic Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity NIK/NF-kappaB Signaling Regulation Of Metabolic Process Toll-like Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Innate Immune Response Positive Regulation Of Cellular Biosynthetic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Cellular Metabolic Process Immune Response-regulating Signaling Pathway Nucleosome Organization Response To Inorganic Substance Positive Regulation Of Transcription, DNA-templated Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Cellular Response To Hydrogen Peroxide Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Chromatin Assembly Or Disassembly Positive Regulation Of Transcription From RNA Polymerase II Promoter	DNA Methylation On Cytosine Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Chromatin Silencing Gene Expression Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromatin Silencing At RDNA DNA Methylation Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Conformation Change Regulation Of Metabolic Process Chromosome Organization DNA Modification DNA Packaging Transcription, DNA-templated Gene Silencing RNA Biosynthetic Process Chromatin Organization Chromatin Assembly Chromatin Assembly Or Disassembly Positive Regulation Of Gene Expression Cellular Component Assembly Regulation Of Gene Expression, Epigenetic DNA Metabolic Process Establishment Of Protein Localization To Chromatin RNA Metabolic Process Nucleosome Assembly Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleosome Organization Cellular Response To Organic Substance Positive Regulation Of Cellular Biosynthetic Process Protein-DNA Complex Assembly Organelle Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated
Tagcloud ?		balpha bbeta bepsilon biochemically casein ck complexed conjugation correspond crel ikappa ikappab ikk1 ikks indirectly initiates locate nonstimulated okadaic p100 p105 p90rsk1 pest phosphorylating purify rela s32 s36 serines	availability biosensor bix01294 chaetocin codc enables expedite fluc2 g4s h3 h4 imaging k9 live lysine mark methylation methylations methyltransferase monitor nude pace preclinical replacement reveals sensor suv39h1 treating utility
Tagcloud (Difference) ?		balpha bbeta bepsilon biochemically casein ck complexed conjugation correspond crel ikappa ikappab ikk1 ikks indirectly initiates locate nonstimulated okadaic p100 p105 p90rsk1 pest phosphorylating purify rela s32 s36 serines	availability biosensor bix01294 chaetocin codc enables expedite fluc2 g4s h3 h4 imaging k9 live lysine mark methylation methylations methyltransferase monitor nude pace preclinical replacement reveals sensor suv39h1 treating utility
Tagcloud (Intersection) ?