SLC18A2 and CSNK1A1

Number of citations of the paper that reports this interaction (PMID 9045708)
14

Data Source:
HPRD (in vitro)

		SLC18A2	CSNK1A1
Gene Name		solute carrier family 18 (vesicular monoamine transporter), member 2	casein kinase 1, alpha 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Membrane Synaptic Vesicle Membrane Dense Core Granule Neuronal Cell Body Terminal Bouton Clathrin-sculpted Monoamine Transport Vesicle Membrane	Condensed Chromosome Kinetochore Cytoplasm Centrosome Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Membrane Nuclear Speck Primary Cilium
	Molecular Function	Amine Transmembrane Transporter Activity Drug Binding Monoamine Transmembrane Transporter Activity Serotonin Transmembrane Transporter Activity Enzyme Binding Heat Shock Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Response To Amphetamine Serotonin Transport Synaptic Transmission Neurotransmitter Secretion Aging Locomotory Behavior Response To Herbicide Post-embryonic Development Response To Zinc Ion Amine Transport Monoamine Transport Dopamine Transport Death Insulin Secretion Endocytic Recycling Cellular Response To Drug Sequestering Of Neurotransmitter Response To Cocaine Glucose Homeostasis Response To Starvation Response To Corticosterone Negative Regulation Of Neurotransmitter Transport Transmembrane Transport Cellular Response To Ammonium Ion Neurotransmitter Loading Into Synaptic Vesicle Negative Regulation Of Reactive Oxygen Species Biosynthetic Process	Protein Phosphorylation Phagocytosis Mitotic Nuclear Division Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Shape Wnt Signaling Pathway Peptidyl-serine Phosphorylation Cell Division Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Na+/Cl- dependent neurotransmitter transporters Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds Norepinephrine Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle SLC-mediated transmembrane transport Transmission across Chemical Synapses	Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin APC truncation mutants have impaired AXIN binding T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex RNF mutants show enhanced WNT signaling and proliferation AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated Hedgehog 'on' state XAV939 inhibits tankyrase, stabilizing AXIN Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT AMER1 mutants destabilize the destruction complex deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by Hedgehog Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome Activation of SMO
Drugs		Amphetamine Reserpine Alseroxylon Benzphetamine Deserpidine Ephedra Ephedrine MMDA 3,4-Methylenedioxymethamphetamine 4-Methoxyamphetamine Dextroamphetamine Methamphetamine Tetrabenazine Isometheptene Propylhexedrine
Diseases
GWAS			Esophageal cancer ( 21642993)
Protein-Protein Interactions		3 interactors: CSNK1A1 CSNK2A1 CSNK2A2	43 interactors: ACTB ADAP1 AP3B1 AP3B2 APC AXIN1 BID CDC25A CHRM3 CREM CTNNB1 EIF2B5 ERF FADD GLI3 GNB2 HMGB1 HMGB2 HNRNPC HSPA4 KPNA2 KPNB1 LGALS3 MAPT MDM4 NFATC3 PARK2 PDE4D PHLPP1 PPP1CC PPP1R14A PPP2R5A PSEN2 RCC1 SLC18A2 SNCA SYT9 TGFBR1 TIAM1 TNFRSF1B TP53 YWHAQ YWHAZ
Entrez ID		6571	1452
HPRD ID		01896	02739
Ensembl ID		ENSG00000165646	ENSG00000113712
Uniprot IDs		Q05940	B4DER9 P48729 Q6PJ06 Q71TU5
PDB IDs
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Mitotic Cell Cycle Process Negative Regulation Of Cellular Protein Catabolic Process Mitotic Cell Cycle Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Negative Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division Cell Cycle Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Wnt Signaling Pathway Mitotic Cell Cycle Checkpoint Protein Phosphorylation Cell Cycle Regulation Of Proteasomal Protein Catabolic Process Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Regulation Of Cell Division Regulation Of Wnt Signaling Pathway Phosphorylation Regulation Of Cellular Component Organization Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Protein Catabolic Process Axon Guidance Regulation Of Protein Processing Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Process Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Phosphate-containing Compound Metabolic Process Chemotaxis Neuron Projection Morphogenesis Regulation Of Proteolysis Cell Surface Receptor Signaling Pathway	Death Apoptotic Process Programmed Cell Death Cell Death Cellular Response To Stimulus Regulation Of Cellular Localization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Signaling Positive Regulation Of Cell Death Response To Organic Substance Response To Stimulus Cell Communication Regulation Of Apoptotic Process Response To Stress Regulation Of Cell Death Regulation Of Protein Localization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Cellular Process Regulation Of Signaling Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Intracellular Transport Execution Phase Of Apoptosis Response To External Stimulus Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cell Death Immune System Process Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Cell Activation Regulation Of Establishment Of Protein Localization Developmental Process Thymus Development Regulation Of Catalytic Activity Signal Transduction Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Positive Regulation Of Mitochondrion Organization Regulation Of Protein Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway T Cell Differentiation In Thymus Regulation Of Cellular Component Organization Regulation Of Protein Complex Assembly Regulation Of Cellular Protein Metabolic Process Leukocyte Activation Positive Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component
Tagcloud ?			aberrantly antagonistic beauty becomes canonical concert connectivity ctnnb1 decipher discover facts functioning gbm gli2 hedgehog imperative integrative interplay missed ranked recapitulate relying shh similarities smo solve sonic surmised wnt
Tagcloud (Difference) ?			aberrantly antagonistic beauty becomes canonical concert connectivity ctnnb1 decipher discover facts functioning gbm gli2 hedgehog imperative integrative interplay missed ranked recapitulate relying shh similarities smo solve sonic surmised wnt
Tagcloud (Intersection) ?