SLC9A5 and ARRB1

Number of citations of the paper that reports this interaction (PubMedID 15699339)
40

Data Source:
HPRD (in vivo)

		SLC9A5	ARRB1
Description		solute carrier family 9 member A5	arrestin beta 1
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Focal Adhesion Membrane Dendritic Spine Membrane Cell Projection Neuron Spine Synapse Postsynaptic Membrane Recycling Endosome Membrane Anchoring Junction Synaptic Membrane	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit Membrane Nuclear Body Cytoplasmic Vesicle Membrane Endocytic Vesicle Membrane Pseudopodium Cytoplasmic Vesicle Cell Projection
	Molecular Function	Protein Binding Antiporter Activity Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity Arrestin Family Protein Binding	G Protein-coupled Receptor Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Enzyme Inhibitor Activity GTPase Activator Activity Insulin-like Growth Factor Receptor Binding Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Angiotensin Receptor Binding Molecular Adaptor Activity Arrestin Family Protein Binding
	Biological Process	Monoatomic Ion Transport Monoatomic Cation Transport Sodium Ion Transport Regulation Of PH Sodium Ion Transmembrane Transport Regulation Of Intracellular PH Transmembrane Transport Potassium Ion Transmembrane Transport Sodium Ion Import Across Plasma Membrane Proton Transmembrane Transport	Positive Regulation Of Protein Phosphorylation Desensitization Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Internalization Positive Regulation Of Receptor Internalization Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Signal Transduction Sensory Perception Negative Regulation Of Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy Protein Transport Protein Ubiquitination Negative Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Rho Protein Signal Transduction Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Intracellular Signal Transduction
Pathways		Sodium/Proton exchangers	Activated NOTCH1 Transmits Signal to the Nucleus G alpha (s) signalling events Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Thrombin signalling through proteinase activated receptors (PARs) Activation of SMO Activation of SMO MAP2K and MAPK activation Ub-specific processing proteases Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Signaling downstream of RAS mutants Signaling by RAF1 mutants TGFBR3 regulates TGF-beta signaling
Drugs
Diseases
GWAS		A body shape index ( 34021172) High density lipoprotein cholesterol levels ( 33339817) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Obstructive sleep apnea trait (average respiratory event duration) ( 26977737) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		5 interacting genes: ARRB1 ARRB2 CHP1 CHP2 RACK1	58 interacting genes: ADH6 ADRB1 ADRB2 AGTR1 AP2B1 ARF6 BAG1 BTK C5AR1 CCR5 CDC42 CLTC CRHR1 CSK CXCR2 CYTH2 DVL1 DVL2 EIF2AK4 FGR FLNA GNMT GPR50 GRK2 GSK3B HCK HCRTR1 JUN LIMK1 MAP2K3 MAP2K4 MAPK1 MAPK10 MAPK3 MAPK9 MDM2 NEDD4L NEK6 NFKBIA NSF OPRD1 PDE4D PIK3R2 POT1 POU2F1 PRDM16 PTH1R PTHLH RALGDS RPL15 SASH1 SLC9A5 SNCA SREBF2 TIAM1 TP53 TRHR ZBTB43
Entrez ID		6553	408
HPRD ID		02723	00146
Ensembl ID		ENSG00000135740	ENSG00000137486
Uniprot IDs		Q14940	B7Z1Q3 P49407
PDB IDs			2IV8 6PWC 6TKO 6UP7 7R0C 7R0J 7SRS 8AS2 8AS3 8AS4 8JRV 8WRZ 9II2 9II3
Enriched GO Terms of Interacting Partners?		Angiotensin Receptor Binding Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Transport Positive Regulation Of Phosphate Metabolic Process Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Protein Ubiquitination Desensitization Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Post-translational Protein Modification Negative Adaptation Of Signaling Pathway Regulation Of Phosphatase Activity G Protein-coupled Receptor Internalization Regulation Of Phosphorus Metabolic Process Regulation Of Transport Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process Regulation Of Protein Modification Process Regulation Of DNA-binding Transcription Factor Activity Molecular Adaptor Activity Regulation Of Protein Ubiquitination Regulation Of Dephosphorylation Regulation Of Intracellular Signal Transduction Positive Regulation Of Receptor Internalization Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Transport Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Endocytosis Positive Regulation Of Establishment Of Protein Localization Protein Transport Negative Regulation Of Interleukin-6 Production Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Protein Modification Process Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Protein Phosphorylation Enzyme Binding Regulation Of Protein Import Into Nucleus Establishment Of Protein Localization Regulation Of Phosphorylation Receptor Internalization Regulation Of Signal Transduction Clathrin-coated Pit Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Protein Localization Regulation Of Protein Transport Endocytic Vesicle Membrane G Protein-coupled Receptor Binding Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Receptor Internalization	Signal Transduction Intracellular Signaling Cassette Cell Surface Receptor Signaling Pathway Regulation Of Transport Regulation Of Signaling Intracellular Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of Biological Quality Plasma Membrane Protein Kinase Activity Cytosol Regulation Of Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Fc Receptor Signaling Pathway Kinase Activity Regulation Of Intracellular Signal Transduction Protein Phosphorylation Regulation Of Multicellular Organismal Process Endocytosis Positive Regulation Of Cellular Component Organization Regulation Of Vesicle-mediated Transport G Protein-coupled Receptor Activity Regulation Of Cellular Component Organization Phosphorylation Positive Regulation Of Organelle Organization Immune Response-regulating Signaling Pathway Import Into Cell Positive Regulation Of Signaling Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Endocytosis Protein Serine/threonine Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Receptor Internalization Positive Regulation Of Cell Communication Regulation Of Cytoskeleton Organization MAP Kinase Activity Regulation Of MAPK Cascade Regulation Of Organelle Organization Protein Serine Kinase Activity Positive Regulation Of Metabolic Process Phosphotyrosine Residue Binding Positive Regulation Of Intracellular Signal Transduction Neuronal Dense Core Vesicle MAPK Cascade Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Cellular Localization
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?