TWSG1 and CHRD

Number of citations of the paper that reports this interaction (PMID 11260715)
41

Data Source:
HPRD (in vitro)

		TWSG1	CHRD
Gene Name		twisted gastrulation BMP signaling modulator 1	chordin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Extracellular Vesicular Exosome	Extracellular Space
	Molecular Function		Protein Binding Heparin Binding Cytokine Binding Syndecan Binding
	Biological Process	Ossification Mesoderm Formation Salivary Gland Morphogenesis Hemopoiesis Cell Differentiation BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Forebrain Development Camera-type Eye Development Negative Regulation Of Osteoblast Differentiation	Skeletal System Development Osteoblast Differentiation Gastrulation With Mouth Forming Second Mesoderm Formation Positive Regulation Of Mesenchymal Cell Proliferation BMP Signaling Pathway Involved In Spinal Cord Dorsal/ventral Patterning Negative Regulation Of Cell Migration Negative Regulation Of BMP Signaling Pathway Forebrain Development Floor Plate Development Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Adhesion
Pathways
Drugs
Diseases
GWAS		Dental caries ( 23064961)	Platelet counts ( 20139978)
Protein-Protein Interactions		4 interactors: BMP1 BMP4 CHRD SGTA	26 interactors: ATN1 BMP1 BMP2 CATSPER1 CD36 F2R HOXA1 HRG KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 KRTAP9-2 MEOX2 NOTCH2NL NR0B2 OTX1 PLSCR1 SMAD3 SPRY2 TLL1 TWSG1
Entrez ID		57045	8646
HPRD ID		05443	04592
Ensembl ID		ENSG00000128791	ENSG00000090539
Uniprot IDs		Q9GZX9	E7ESX1 Q9H2X0
PDB IDs
Enriched GO Terms of Interacting Partners?		Ossification Positive Regulation Of Cartilage Development Regulation Of Mesenchymal Cell Proliferation Skeletal System Development BMP Signaling Pathway Regulation Of BMP Signaling Pathway Mesoderm Formation Regulation Of Cartilage Development Mesoderm Morphogenesis Regulation Of Stem Cell Proliferation Dorsal/ventral Pattern Formation Negative Regulation Of Metanephric S-shaped Body Morphogenesis Negative Regulation Of Metanephric Comma-shaped Body Morphogenesis BMP Signaling Pathway Involved In Spinal Cord Dorsal/ventral Patterning Mesenchymal Cell Proliferation Involved In Ureter Development Ureter Epithelial Cell Differentiation Negative Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Pulmonary Artery Endothelial Tube Morphogenesis BMP Signaling Pathway Involved In Renal System Segmentation BMP Signaling Pathway Involved In Ureter Morphogenesis Negative Regulation Of Branch Elongation Involved In Ureteric Bud Branching By BMP Signaling Pathway Specification Of Ureteric Bud Anterior/posterior Symmetry By BMP Signaling Pathway Positive Regulation Of Cardiac Muscle Fiber Development Bud Dilation Involved In Lung Branching Epithelial Cell Proliferation Involved In Lung Morphogenesis BMP Signaling Pathway Involved In Nephric Duct Formation Intermediate Mesodermal Cell Differentiation Regulation Of Osteoblast Differentiation Formation Of Primary Germ Layer Osteoblast Differentiation Mesoderm Development Intermediate Mesoderm Development Gastrulation Neural Tube Development Cartilage Development Regulation Of Ossification Negative Regulation Of Glomerular Mesangial Cell Proliferation Ureter Urothelium Development Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Cloacal Septation Negative Regulation Of Glomerulus Development Mesodermal Cell Fate Determination BMP Signaling Pathway Involved In Heart Induction Deltoid Tuberosity Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Connective Tissue Development Ureter Morphogenesis Ureter Smooth Muscle Cell Differentiation Regulation Of Branch Elongation Involved In Ureteric Bud Branching	Developmental Process Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Anatomical Structure Development Positive Regulation Of Gene Expression Anterior/posterior Pattern Specification Positive Regulation Of Blood Coagulation Regulation Of Wound Healing Anatomical Structure Morphogenesis Positive Regulation Of Coagulation Positive Regulation Of Cartilage Development Sensory Organ Development Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Wound Healing Organ Morphogenesis System Development Regulation Of Transcription, DNA-templated Positive Regulation Of Cell-matrix Adhesion Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Inner Ear Development Embryo Development Platelet Activation Pattern Specification Process Embryonic Organ Development Ear Development Positive Regulation Of Transcription, DNA-templated Response To Organic Substance Regulation Of Cartilage Development Positive Regulation Of Cellular Metabolic Process Skeletal System Development Regulation Of Blood Coagulation Ossification Positive Regulation Of Metabolic Process Inner Ear Morphogenesis Wound Healing Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cell Motility Embryonic Organ Morphogenesis Regulation Of Cell-matrix Adhesion Embryonic Morphogenesis Regulation Of Protein Phosphorylation Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Cellular Biosynthetic Process Regulation Of Osteoblast Proliferation Negative Regulation Of Cell Proliferation
Tagcloud ?		acted anomaly bmp bmp2 concert dams e11 e9 embryonal expressivity forebrain gastrulation gavage geometric holoprosencephaly hpe manifested microct midface midline morphometric narrowing ntd overt p19 penetrance predisposing teratogenesis twisted	affymetrix axin2 bglap2 bmp bridge chrdl2 cooperatively cpz csnk2a1 deformities fgfr1 fibrogenic fzd1 fzd2 groupings hgn id1 lef1 microdissection mmp9 osteogenic plate remodelling repaired sfrp1 sfrp4 spp1 tcf7 wisp1
Tagcloud (Difference) ?		acted anomaly bmp2 concert dams e11 e9 embryonal expressivity forebrain gastrulation gavage geometric holoprosencephaly hpe manifested microct midface midline morphometric narrowing ntd overt p19 penetrance predisposing teratogenesis twisted	affymetrix axin2 bglap2 bridge chrdl2 cooperatively cpz csnk2a1 deformities fgfr1 fibrogenic fzd1 fzd2 groupings hgn id1 lef1 microdissection mmp9 osteogenic plate remodelling repaired sfrp1 sfrp4 spp1 tcf7 wisp1
Tagcloud (Intersection) ?		bmp