TWSG1 and GPRC5D

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TWSG1	GPRC5D
Description		twisted gastrulation BMP signaling modulator 1	G protein-coupled receptor class C group 5 member D
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Membrane Intracellular Membrane-bounded Organelle Receptor Complex Extracellular Exosome
	Molecular Function	Protein Binding Heparin Binding Transforming Growth Factor Beta Binding	G Protein-coupled Receptor Activity Protein Binding Protein Kinase Activator Activity
	Biological Process	Ossification Mesoderm Formation Negative Regulation Of Cytokine Production Chondrocyte Differentiation Salivary Gland Morphogenesis Tissue Development Hemopoiesis BMP Signaling Pathway Regulation Of BMP Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Forebrain Development Camera-type Eye Development Negative Regulation Of Osteoblast Differentiation Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of CD4-positive, Alpha-beta T Cell Activation Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation	Signal Transduction G Protein-coupled Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Dental caries ( 23064961)
Interacting Genes		10 interacting genes: BMP1 BMP4 CHRD FAM209A FNDC9 GJA8 GPRC5D LRRC4C SGTA TNS2	30 interacting genes: APOL3 BTN2A2 C14orf180 C1GALT1 CCL4 EMP1 ERMP1 FXYD3 FXYD6-FXYD2 GYPA IFITM3 IGFBP5 LHFPL5 LRRC25 MS4A6A OSMR PMP22 PRRT2 PVR SLC30A2 SLC66A1 SYNDIG1 TMEM120B TMEM19 TMEM208 TMEM79 TRARG1 TWSG1 UNC93B1 YIPF1
Entrez ID		57045	55507
HPRD ID		05443	07604
Ensembl ID		ENSG00000128791	ENSG00000111291
Uniprot IDs		Q9GZX9	Q9NZD1
PDB IDs		8BWA 8BWD 8BWI 8BWL 8BWM 8BWN	8YZK 9IMA
Enriched GO Terms of Interacting Partners?		Dorsal/ventral Pattern Formation Positive Regulation Of Cartilage Development Skeletal System Development Regionalization Negative Regulation Of Metanephric Comma-shaped Body Morphogenesis Bud Dilation Involved In Lung Branching Apoptotic Process Involved In Endocardial Cushion Morphogenesis Negative Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Intermediate Mesodermal Cell Differentiation Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Metanephric S-shaped Body Morphogenesis Positive Regulation Of Cardiac Muscle Fiber Development Negative Regulation Of Glomerulus Development Negative Regulation Of BMP Signaling Pathway Regulation Of Cartilage Development Positive Regulation Of Primary MiRNA Processing Tendon Cell Differentiation Negative Regulation Of Branching Involved In Ureteric Bud Morphogenesis Camera-type Eye Development BMP Signaling Pathway Positive Regulation Of Branching Involved In Lung Morphogenesis TRC Complex Pattern Specification Process Growth Factor Activity Cartilage Development Ossification Apoptotic Process Involved In Heart Morphogenesis Regulation Of Osteoblast Differentiation Positive Regulation Of MiRNA Processing Negative Regulation Of Glomerular Mesangial Cell Proliferation Nephric Duct Formation Bronchus Development Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Deltoid Tuberosity Development Epithelial Cell Proliferation Involved In Lung Morphogenesis Cardiac Jelly Development Eye Development Negative Regulation Of Immature T Cell Proliferation Prostate Gland Morphogenesis Epithelial-mesenchymal Cell Signaling Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Branching Involved In Lung Morphogenesis Telencephalon Regionalization Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Branching Involved In Prostate Gland Morphogenesis Glomerular Capillary Formation Pericyte Cell Differentiation Specification Of Animal Organ Position Regulation Of BMP Signaling Pathway Trachea Development	Membrane
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