MT-ATP8 and WNK1

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		MT-ATP8	WNK1
Description		ATP synthase F0 subunit 8	WNK lysine deficient protein kinase 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane Proton-transporting ATP Synthase Complex	Nucleus Cytoplasm Spindle Cytosol Cytoskeleton Membrane Protein-containing Complex Intracellular Membraneless Organelle Mitotic Spindle
	Molecular Function	Protein Binding Proton Transmembrane Transporter Activity Proton-transporting ATP Synthase Activity, Rotational Mechanism	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Phosphatase Binding Protein Kinase Activator Activity Protein Serine Kinase Activity Molecular Condensate Scaffold Activity
	Biological Process	ATP Biosynthetic Process Monoatomic Ion Transport Proton Motive Force-driven ATP Synthesis Proton Motive Force-driven Mitochondrial ATP Synthesis Proton Transmembrane Transport	Regulation Of Sodium Ion Transport Positive Regulation Of Systemic Arterial Blood Pressure Protein Phosphorylation Monoatomic Ion Transport Cell Volume Homeostasis DNA Damage Response Signal Transduction Heart Development Regulation Of Blood Pressure Negative Regulation Of Autophagy Negative Regulation Of Sodium Ion Transport Regulation Of MRNA Export From Nucleus Positive Regulation Of T Cell Chemotaxis Intracellular Chloride Ion Homeostasis Negative Regulation Of Protein Ubiquitination Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Negative Regulation Of Heterotypic Cell-cell Adhesion Intracellular Signal Transduction Sodium Ion Transmembrane Transport Chemokine (C-C Motif) Ligand 21 Signaling Pathway Homeostatic Process Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence Positive Regulation Of Angiogenesis Neuron Development T Cell Receptor Signaling Pathway Negative Regulation Of Small GTPase Mediated Signal Transduction Potassium Ion Homeostasis Monoatomic Cation Homeostasis Cellular Hyperosmotic Response Potassium Ion Transmembrane Transport Negative Regulation Of Pancreatic Juice Secretion Positive Regulation Of Canonical Wnt Signaling Pathway Lymphocyte Migration Into Lymph Node Membraneless Organelle Assembly Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Mitotic Cytokinesis Regulation Of Monoatomic Cation Transmembrane Transport Positive Regulation Of Termination Of RNA Polymerase II Transcription Cellular Response To Chemokine
Pathways		Formation of ATP by chemiosmotic coupling Mitochondrial translation termination Cristae formation	Stimuli-sensing channels
Drugs
Diseases			Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS			Adult body size ( 32376654) Body mass index ( 25673413 29273807) Body size at age 10 ( 32376654) Eosinophil count ( 27863252) Eosinophil percentage of white cells ( 27863252) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Manganese levels ( 26025379) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Squamous cell lung carcinoma ( 28604730) Stroke ( 19369658)
Interacting Genes		4 interacting genes: GRB2 PACSIN1 RAPGEF2 WNK1	36 interacting genes: ADRB2 AKT1 ARAF ATXN1 BAG3 CLTC COPS5 CSDE1 E2F3 FHL3 FLNC GLIS2 KLHL2 MAP2K1 MAP3K2 MAP3K3 MT-ATP8 OXSR1 PFKP PRKAR1A PRKAR1B PVR RANBP9 SLC9A1 SYT2 TNRC6A TSC22D1 TULP3 UBE2I UPF2 WNK2 YWHAE YWHAG YWHAZ ZNF106 ZYX
Entrez ID		4509	65125
HPRD ID			05570
Ensembl ID		ENSG00000228253	ENSG00000060237
Uniprot IDs		P03928 U5YV54	A5D8Z4 F5GWT4 Q9H4A3
PDB IDs		8H9F 8H9J 8H9M 8H9Q 8H9S 8H9T 8H9U 8H9V 8KHF 8KI3	4PWN 5TF9 5WDY 5WE8 6FBK
Enriched GO Terms of Interacting Partners?		Cell Development Neuron Development Positive Regulation Of Cellular Component Organization Ras Protein Signal Transduction Localization Within Membrane Guanyl-nucleotide Exchange Factor Adaptor Activity Regulation Of Dendrite Development Presynaptic Endocytic Zone Regulation Of Cellular Component Organization Cell-cell Junction Antigen Receptor-mediated Signaling Pathway Endosome Cellular Developmental Process Grb2-EGFR Complex Protein Localization To Plasma Membrane Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Neuron Projection Development CAMP-mediated Signaling Positive Regulation Of CAMP-dependent Protein Kinase Activity Negative Regulation Of Melanin Biosynthetic Process Beta-1 Adrenergic Receptor Binding Positive Regulation Of Dendritic Cell Apoptotic Process Lymphocyte Migration Into Lymph Node Positive Regulation Of Termination Of DNA-templated Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription Chemokine (C-C Motif) Ligand 21 Signaling Pathway Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Protein Localization To Cell Periphery Regulation Of Cellular Component Size Regulation Of Leukocyte Cell-cell Adhesion Immune Response-regulating Signaling Pathway Small GTPase-mediated Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Branching Involved In Labyrinthine Layer Morphogenesis Insulin Receptor Substrate Binding Immune Response-activating Signaling Pathway Activation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Neurotrophin TRKA Receptor Binding Cellular Response To CGMP Negative Regulation Of Dendrite Morphogenesis Microvillus Organization Positive Regulation Of Neuron Migration Establishment Of Endothelial Intestinal Barrier Diacylglycerol Binding Regulation Of Melanin Biosynthetic Process Rap Protein Signal Transduction Positive Regulation Of Protein Binding Cellular Localization	Cytoplasm Cytosol Focal Adhesion MAPK Cascade Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Serine Kinase Activity Enzyme Binding Response To Temperature Stimulus Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Signal Transduction Kinase Activity Intracellular Signal Transduction Establishment Of Localization In Cell Insulin-like Growth Factor Receptor Signaling Pathway Intracellular Signaling Cassette Phosphoserine Residue Binding Protein Kinase Activity Regulation Of Protein Localization Positive Regulation Of Toll-like Receptor Signaling Pathway CAMP-dependent Protein Kinase Regulator Activity Negative Regulation Of Immune System Process Ciliary Base Protein Sequestering Activity Regulation Of CAMP/PKA Signal Transduction Intracellular Transport Protein Autophosphorylation Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Binding Identical Protein Binding Nuclear Transport Nucleocytoplasmic Transport RNA Binding CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity ERK1 And ERK2 Cascade Regulation Of Membrane Potential Regulation Of TOR Signaling Positive Regulation Of Signal Transduction Regulation Of Protein Localization To Nucleus Protein Kinase Binding TORC1 Signaling
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