MT-ATP8 and RAPGEF2

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		MT-ATP8	RAPGEF2
Description		ATP synthase F0 subunit 8	Rap guanine nucleotide exchange factor 2
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane Proton-transporting ATP Synthase Complex	Cytoplasm Endosome Late Endosome Cytosol Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Apical Plasma Membrane Endocytic Vesicle Protein-containing Complex Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Anchoring Junction
	Molecular Function	Protein Binding Proton Transmembrane Transporter Activity Proton-transporting ATP Synthase Activity, Rotational Mechanism	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Diacylglycerol Binding PDZ Domain Binding CAMP Binding CGMP Binding Beta-1 Adrenergic Receptor Binding WW Domain Binding Phosphatidic Acid Binding
	Biological Process	ATP Biosynthetic Process Monoatomic Ion Transport Proton Motive Force-driven ATP Synthesis Proton Motive Force-driven Mitochondrial ATP Synthesis Proton Transmembrane Transport	MAPK Cascade Blood Vessel Development Neuron Migration Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Nervous System Development Negative Regulation Of Cell Population Proliferation Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development CAMP-mediated Signaling Ventricular System Development Forebrain Neuron Development Microvillus Assembly Cell Differentiation Neuron Projection Development Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Protein Binding Rap Protein Signal Transduction Intracellular Signal Transduction Nerve Growth Factor Signaling Pathway Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Negative Regulation Of Melanin Biosynthetic Process Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Cellular Response To CGMP Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier Regulation Of Cell Junction Assembly Positive Regulation Of Microvillus Assembly Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Dendritic Cell Apoptotic Process Positive Regulation Of Vasculogenesis Positive Regulation Of Neuron Migration
Pathways		Formation of ATP by chemiosmotic coupling Mitochondrial translation termination Cristae formation	RAF/MAP kinase cascade
Drugs
Diseases
GWAS			Dietary fat liking ( 32516399) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Molybdenum levels ( 26025379) Uterine fibroid number (single vs multiple) ( 30196971)
Interacting Genes		4 interacting genes: GRB2 PACSIN1 RAPGEF2 WNK1	14 interacting genes: CTNNB1 DYRK1A HSPA1A IL16 KIF5A KIF5B MAGI2 MOB4 MT-ATP8 NEDD4 RALGDS RAP1A RAP2B SPP1
Entrez ID		4509	9693
HPRD ID			19358
Ensembl ID		ENSG00000228253	ENSG00000109756
Uniprot IDs		P03928 U5YV54	A0A994J7S7 Q9Y4G8
PDB IDs		8H9F 8H9J 8H9M 8H9Q 8H9S 8H9T 8H9U 8H9V 8KHF 8KI3	6QDT
Enriched GO Terms of Interacting Partners?		Cell Development Neuron Development Positive Regulation Of Cellular Component Organization Ras Protein Signal Transduction Localization Within Membrane Guanyl-nucleotide Exchange Factor Adaptor Activity Regulation Of Dendrite Development Presynaptic Endocytic Zone Regulation Of Cellular Component Organization Cell-cell Junction Antigen Receptor-mediated Signaling Pathway Endosome Cellular Developmental Process Grb2-EGFR Complex Protein Localization To Plasma Membrane Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Neuron Projection Development CAMP-mediated Signaling Positive Regulation Of CAMP-dependent Protein Kinase Activity Negative Regulation Of Melanin Biosynthetic Process Beta-1 Adrenergic Receptor Binding Positive Regulation Of Dendritic Cell Apoptotic Process Lymphocyte Migration Into Lymph Node Positive Regulation Of Termination Of DNA-templated Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription Chemokine (C-C Motif) Ligand 21 Signaling Pathway Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Protein Localization To Cell Periphery Regulation Of Cellular Component Size Regulation Of Leukocyte Cell-cell Adhesion Immune Response-regulating Signaling Pathway Small GTPase-mediated Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Branching Involved In Labyrinthine Layer Morphogenesis Insulin Receptor Substrate Binding Immune Response-activating Signaling Pathway Activation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Neurotrophin TRKA Receptor Binding Cellular Response To CGMP Negative Regulation Of Dendrite Morphogenesis Microvillus Organization Positive Regulation Of Neuron Migration Establishment Of Endothelial Intestinal Barrier Diacylglycerol Binding Regulation Of Melanin Biosynthetic Process Rap Protein Signal Transduction Positive Regulation Of Protein Binding Cellular Localization	Perinuclear Region Of Cytoplasm Postsynaptic Cytosol Synaptic Vesicle Transport Retrograde Neuronal Dense Core Vesicle Transport Regulation Of Transport Ciliary Rootlet Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Anterograde Axonal Protein Transport Dense Core Granule Cytoskeletal Transport Rap Protein Signal Transduction Anterograde Dendritic Transport Protein Transport Along Microtubule Nerve Growth Factor Signaling Pathway Nervous System Development Establishment Of Vesicle Localization Dendritic Transport Plus-end-directed Microtubule Motor Activity Bicellular Tight Junction Vesicle Localization Regulation Of Inclusion Body Assembly Retrograde Axonal Transport Secretory Granule Localization Neuron Projection Regulation Of Metal Ion Transport Epithelial Cell Development Apicolateral Plasma Membrane Disordered Domain Specific Binding Dendrite Cytoplasm Intracellular Signal Transduction Neurotrophin Signaling Pathway Regulation Of Cellular Component Organization Negative Regulation Of Intracellular Signal Transduction Regulation Of Monoatomic Ion Transport Regulation Of Neuron Projection Development Positive Regulation Of Transport Vesicle Regulation Of Cell Communication Regulation Of Signaling Establishment Of Endothelial Barrier Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Endothelial Cell Development Positive Regulation Of RNA Splicing Cellular Response To Nerve Growth Factor Stimulus Vesicle Transport Along Microtubule Kinesin Complex Anterograde Axonal Transport Response To Nerve Growth Factor Cytoskeleton
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