ATP8 and RAPGEF2

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		ATP8	RAPGEF2
Gene Name		ATP synthase F0 subunit 8	Rap guanine nucleotide exchange factor (GEF) 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Cytoplasm Late Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Tight Junction Membrane Apical Plasma Membrane Endocytic Vesicle Neuron Projection Neuronal Cell Body Protein Complex Synapse Perinuclear Region Of Cytoplasm
	Molecular Function		Signal Transducer Activity Ras Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Rap Guanyl-nucleotide Exchange Factor Activity Protein Kinase Binding Diacylglycerol Binding PDZ Domain Binding CAMP Binding CGMP Binding Beta-1 Adrenergic Receptor Binding Rap GTPase Activator Activity WW Domain Binding Phosphatidic Acid Binding
	Biological Process		MAPK Cascade Blood Vessel Development Neuron Migration G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Small GTPase Mediated Signal Transduction Negative Regulation Of Cell Proliferation Positive Regulation Of Neuron Projection Development CAMP-mediated Signaling Ventricular System Development Forebrain Neuron Development Microvillus Assembly Neuron Projection Development Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Protein Binding Positive Regulation Of Ras GTPase Activity Rap Protein Signal Transduction Positive Regulation Of Rap GTPase Activity Intracellular Signal Transduction Nerve Growth Factor Signaling Pathway Positive Regulation Of CAMP-mediated Signaling Positive Regulation Of Protein Kinase Activity Negative Regulation Of Melanin Biosynthetic Process Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Cellular Response To CGMP Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier Regulation Of Cell Junction Assembly Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Dendritic Cell Apoptotic Process Positive Regulation Of Vasculogenesis Positive Regulation Of Neuron Migration
Pathways		Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. The citric acid (TCA) cycle and respiratory electron transport Formation of ATP by chemiosmotic coupling
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: GRB2 PACSIN1 RAPGEF2 WNK1	12 interactors: ATP8 CTNNB1 HSPA1A KIF5A KIF5B MAGI2 MOB4 NEDD4 RALGDS RAP1A RAP2B SPP1
Entrez ID		4509	9693
HPRD ID			19358
Ensembl ID			ENSG00000109756
Uniprot IDs		P03928 Q85BD0	Q9Y4G8
PDB IDs
Enriched GO Terms of Interacting Partners?		Neuron Development Neuron Differentiation Generation Of Neurons Neurogenesis Cell Development Nervous System Development Regulation Of Dendrite Development Neuron Projection Development Protein Localization To Plasma Membrane Negative Regulation Of Melanin Biosynthetic Process Cell Differentiation Cell Projection Organization Brain-derived Neurotrophic Factor Receptor Signaling Pathway Ras Protein Signal Transduction Plasma Membrane Organization Positive Regulation Of Neuron Projection Development Neurotrophin Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Dendritic Cell Apoptotic Process Regulation Of Phosphorylation Negative Regulation Of Pancreatic Juice Secretion Positive Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Cell Projection Organization Regulation Of Phosphorus Metabolic Process System Development Establishment Of Endothelial Intestinal Barrier Cellular Response To CGMP Positive Regulation Of Neuron Differentiation Response To CGMP Negative Regulation Of Dendrite Morphogenesis Protein Localization To Membrane Rap Protein Signal Transduction Regulation Of Neuron Projection Development Negative Regulation Of Transport Branching Involved In Labyrinthine Layer Morphogenesis Multicellular Organismal Development Positive Regulation Of Neurogenesis Intracellular Signal Transduction Anatomical Structure Development Endomembrane System Organization Regulation Of Cellular Component Organization Positive Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Vasculogenesis Nerve Growth Factor Signaling Pathway Regulation Of CAMP-dependent Protein Kinase Activity Cellular Response To Organonitrogen Compound Positive Regulation Of CAMP-mediated Signaling Positive Regulation Of Neuron Migration Regulation Of Cell Projection Organization Microvillus Assembly	Generation Of Neurons Neurogenesis Rap Protein Signal Transduction Regulation Of Cellular Component Organization Regulation Of Neurogenesis Locomotion Nerve Growth Factor Signaling Pathway Regulation Of Neuron Projection Development Regulation Of Cell Development Nervous System Development Regulation Of Cell Differentiation Establishment Of Endothelial Barrier Response To Organic Substance Regulation Of Cell Projection Organization Cellular Response To Nerve Growth Factor Stimulus Regulation Of Neuron Differentiation Cell Development Epithelial Cell Development Cellular Response To Growth Factor Stimulus Ras Protein Signal Transduction Neurotrophin Signaling Pathway Response To Growth Factor Negative Regulation Of Signaling Establishment Of Localization In Cell Endothelial Cell Development Regulation Of Signaling Cell Activation Regulation Of Potassium Ion Transport Cell Differentiation Homotypic Cell-cell Adhesion Response To Stress Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Transmission Of Virus Development Involved In Symbiotic Interaction Cellular Localization Intracellular Transport Intracellular Steroid Hormone Receptor Signaling Pathway Endothelial Cell Differentiation Positive Regulation Of Cell Differentiation Response To Stimulus Transport Endothelium Development Positive Regulation Of Neurogenesis Tissue Development Negative Regulation Of Mitotic Cell Cycle, Embryonic Cellular Heat Acclimation Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Stress Granule Disassembly Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury
Tagcloud ?		abolishing activators belongs chloroplasts coimmunoprecipitation cooperativity cox1 cytochrome deletion demonstrates disrupted entire entirely largest mitochondria motifs mrna mss51 oxidase pentatricopeptide pet309 polycistronic portion ppr predicts selectively translational undetectable utr	adapter aneuploidy betatrcp2 biochemistry comprehensively computation cul1 destabilized fbxw11 guanine identifier immunopurified instrumentation ligases multinucleation necessitates pac polyubiquitylated processivity proteomexchange proteomics putatively pxd001062 rap1 scf skp1 ubiquitylated ubiquitylation
Tagcloud (Difference) ?		abolishing activators belongs chloroplasts coimmunoprecipitation cooperativity cox1 cytochrome deletion demonstrates disrupted entire entirely largest mitochondria motifs mrna mss51 oxidase pentatricopeptide pet309 polycistronic portion ppr predicts selectively translational undetectable utr	adapter aneuploidy betatrcp2 biochemistry comprehensively computation cul1 destabilized fbxw11 guanine identifier immunopurified instrumentation ligases multinucleation necessitates pac polyubiquitylated processivity proteomexchange proteomics putatively pxd001062 rap1 scf skp1 ubiquitylated ubiquitylation
Tagcloud (Intersection) ?