VPS33A and VPS18

Number of citations of the paper that reports this interaction (PubMedID 11382755)
0

Data Source:
HPRD (in vivo)

		VPS33A	VPS18
Description		VPS33A core subunit of CORVET and HOPS complexes	VPS18 core subunit of CORVET and HOPS complexes
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Endosome Membrane Membrane AP-3 Adaptor Complex Clathrin-coated Vesicle HOPS Complex Cytoplasmic Vesicle Late Endosome Membrane CORVET Complex Perinuclear Region Of Cytoplasm Clathrin Complex	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Actin Filament Endosome Membrane Endomembrane System Membrane AP-3 Adaptor Complex Clathrin-coated Vesicle HOPS Complex Cytoplasmic Vesicle Late Endosome Membrane CORVET Complex Presynapse Glutamatergic Synapse
	Molecular Function	Protein Binding	Actin Binding Protein Binding Zinc Ion Binding Syntaxin Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Intracellular Protein Transport Autophagy Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Platelet Formation Melanosome Localization Lysosome Localization Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Regulation Of Lysosomal Lumen PH Pigmentation Regulation Of Developmental Pigmentation Autophagosome Maturation	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Autophagy Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Protein Ubiquitination Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Symbiont Entry Into Host Cell Organelle Fusion Regulation Of Synaptic Vesicle Exocytosis
Pathways		SARS-CoV-2 modulates autophagy	SARS-CoV-2 modulates autophagy
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)	Hemoglobin ( 32888494) Malaria ( 31844061) Refractive error ( 32231278) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		7 interacting genes: MON1A MON1B ROPN1 TNKS VPS11 VPS16 VPS18	22 interacting genes: AKTIP COPB1 EP300 GGA1 GGA2 GGA3 HOOK1 MON1B PLEKHM1 RAB7A RILP SHANK3 STX1A STX6 STX7 STX8 UBE2D2 UVRAG VPS11 VPS16 VPS33A VPS45
Entrez ID		65082	57617
HPRD ID		15651	09776
Ensembl ID		ENSG00000139719	ENSG00000104142
Uniprot IDs		F5H6Y0 Q96AX1	Q9P253
PDB IDs		4BX8 4BX9
Enriched GO Terms of Interacting Partners?		Vacuolar Transport CORVET Complex Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion HOPS Complex Intracellular Protein Localization Protein Transport Intracellular Protein Transport Vesicle Tethering Complex Establishment Of Protein Localization Endosome To Lysosome Transport Mon1-Ccz1 Complex Clathrin-coated Vesicle Autophagosome Vesicle Fusion Organelle Membrane Fusion Lysosomal Transport Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Organelle Fusion Vesicle-mediated Transport Late Endosome Membrane Late Endosome Membrane Fusion Intracellular Transport Vacuole Organization Protein Localization To Organelle Cellular Localization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Establishment Of Localization In Cell Vesicle Docking Involved In Exocytosis Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Endosome Membrane Syntaxin Binding Autophagy Protein Targeting To Vacuole Vesicle Organization Early Endosome Vesicle Docking Establishment Of Protein Localization To Vacuole Lysosomal Membrane Organelle Localization By Membrane Tethering Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Endosome Organization Regulation Of Protein-containing Complex Assembly Membrane Docking Protein Localization To Vacuole Lysosome Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric Early Viral Transcription Vacuole Fusion, Non-autophagic	Protein Transport Intracellular Protein Localization Vesicle-mediated Transport Intracellular Transport Cellular Localization Establishment Of Localization In Cell Establishment Of Protein Localization Intracellular Protein Transport Endosome Vesicle Organization Vesicle Fusion Organelle Membrane Fusion Vacuolar Transport Lysosomal Transport Organelle Fusion Membrane Fusion Late Endosome Endosome To Lysosome Transport Endosome Membrane Early Endosome HOPS Complex Endosomal Transport Early Endosome To Late Endosome Transport Membrane Organization Lysosome Late Endosome Membrane Membrane Docking Cytoplasmic Vesicle Organelle Localization Vesicle Docking Lysosomal Membrane SNARE Binding Recycling Endosome Organelle Organization Clathrin-coated Vesicle Organelle Localization By Membrane Tethering Chloride Channel Inhibitor Activity Endosome Organization CORVET Complex Phagocytic Vesicle Vacuole Organization SNAP Receptor Activity SNARE Complex Syntaxin Binding Vesicle-mediated Transport To The Plasma Membrane Establishment Of Protein Localization To Plasma Membrane Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Golgi Vesicle Transport Autophagy
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