VPS33A and MON1A

Number of citations of the paper that reports this interaction (PubMedID 20434987)
0

Data Source:
BioGRID (pull down)

		VPS33A	MON1A
Description		VPS33A core subunit of CORVET and HOPS complexes	MON1 vesicular trafficking associated A
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Endosome Membrane Membrane AP-3 Adaptor Complex Clathrin-coated Vesicle HOPS Complex Cytoplasmic Vesicle Late Endosome Membrane CORVET Complex Perinuclear Region Of Cytoplasm Clathrin Complex	Cytosol Mon1-Ccz1 Complex
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Intracellular Protein Transport Autophagy Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Platelet Formation Melanosome Localization Lysosome Localization Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Regulation Of Lysosomal Lumen PH Pigmentation Regulation Of Developmental Pigmentation Autophagosome Maturation	Protein Targeting To Vacuole Protein Secretion Vesicle-mediated Transport
Pathways		SARS-CoV-2 modulates autophagy	RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)	Age at first birth ( 27798627) Body mass index ( 28892062 29273807 25673413) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Extremely high intelligence ( 29520040) Gastroesophageal reflux disease ( 31527586) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		7 interacting genes: MON1A MON1B ROPN1 TNKS VPS11 VPS16 VPS18	6 interacting genes: GFI1B MAPK6 RABGEF1 RGS2 TAB1 VPS33A
Entrez ID		65082	84315
HPRD ID		15651	17586
Ensembl ID		ENSG00000139719	ENSG00000164077
Uniprot IDs		F5H6Y0 Q96AX1	Q86VX9
PDB IDs		4BX8 4BX9
Enriched GO Terms of Interacting Partners?		Vacuolar Transport CORVET Complex Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion HOPS Complex Intracellular Protein Localization Protein Transport Intracellular Protein Transport Vesicle Tethering Complex Establishment Of Protein Localization Endosome To Lysosome Transport Mon1-Ccz1 Complex Clathrin-coated Vesicle Autophagosome Vesicle Fusion Organelle Membrane Fusion Lysosomal Transport Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Organelle Fusion Vesicle-mediated Transport Late Endosome Membrane Late Endosome Membrane Fusion Intracellular Transport Vacuole Organization Protein Localization To Organelle Cellular Localization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Establishment Of Localization In Cell Vesicle Docking Involved In Exocytosis Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Endosome Membrane Syntaxin Binding Autophagy Protein Targeting To Vacuole Vesicle Organization Early Endosome Vesicle Docking Establishment Of Protein Localization To Vacuole Lysosomal Membrane Organelle Localization By Membrane Tethering Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Endosome Organization Regulation Of Protein-containing Complex Assembly Membrane Docking Protein Localization To Vacuole Lysosome Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric Early Viral Transcription Vacuole Fusion, Non-autophagic	Septin Cytoskeleton Negative Regulation Of Glycine Import Across Plasma Membrane Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Intracellular Transport Organelle Localization Lysosome Localization Negative Regulation Of Kit Signaling Pathway Negative Regulation Of Mast Cell Cytokine Production Autophagosome Vesicle Localization Kit Signaling Pathway Adenylate Cyclase Inhibitor Activity Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Relaxation Of Smooth Muscle Relaxation Of Vascular Associated Smooth Muscle Mitogen-activated Protein Kinase P38 Binding Cellular Localization Establishment Of Localization In Cell Endosome Transport Along Microtubule Mast Cell Migration Negative Regulation Of Mast Cell Degranulation Cytoskeleton-dependent Intracellular Transport CORVET Complex Late Endosome Plus-end-directed Vesicle Transport Along Microtubule Plus-end-directed Organelle Transport Along Microtubule Positive Regulation Of Autophagosome Maturation Positive Regulation Of CGAS/STING Signaling Pathway Microtubule-based Transport Presynaptic Endosome Clathrin Complex Intracellular Signaling Cassette Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Mast Cell Activation
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