VPS33A and ROPN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VPS33A	ROPN1
Description		VPS33A core subunit of CORVET and HOPS complexes	rhophilin associated tail protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Endosome Membrane Membrane AP-3 Adaptor Complex Clathrin-coated Vesicle HOPS Complex Cytoplasmic Vesicle Late Endosome Membrane CORVET Complex Perinuclear Region Of Cytoplasm Clathrin Complex	Nucleus Cytoplasm Cilium Motile Cilium Cell Projection
	Molecular Function	Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Intracellular Protein Transport Autophagy Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Platelet Formation Melanosome Localization Lysosome Localization Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Regulation Of Lysosomal Lumen PH Pigmentation Regulation Of Developmental Pigmentation Autophagosome Maturation	Flagellated Sperm Motility Cilium Organization Sperm Capacitation Protein Localization To Cilium
Pathways		SARS-CoV-2 modulates autophagy	RHO GTPases Activate Rhotekin and Rhophilins
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)	Benign childhood epilepsy with centro-temporal spikes ( 32580138) Household income ( 31844048) Household income (MTAG) ( 31844048)
Interacting Genes		7 interacting genes: MON1A MON1B ROPN1 TNKS VPS11 VPS16 VPS18	50 interacting genes: AKAIN1 AKAP14 AKAP3 AKAP5 AKAP7 AP1M1 BTBD16 CDC37 CEP57L1 CKS1B CNST DBF4B ERCC3 FAM110A FAM153A FAM153B FAM161A FAM90A1 GNL3L GPKOW HNRNPUL1 KIAA0753 KIF9 LENG1 LMO4 LNX1 LNX2 NTAQ1 PICK1 PKP2 POLR3C PRDM6 PRKAA1 PSMA1 RHPN1 RTP5 SDCBP SERTAD1 SORBS3 SPA17 SPG21 SYTL4 TRIM3 TSGA10IP TSHZ3 TSNAXIP1 TULP3 UBE2W VPS33A XKR3
Entrez ID		65082	54763
HPRD ID		15651	15269
Ensembl ID		ENSG00000139719	ENSG00000065371
Uniprot IDs		F5H6Y0 Q96AX1	A0A140VKB2 Q9HAT0
PDB IDs		4BX8 4BX9
Enriched GO Terms of Interacting Partners?		Vacuolar Transport CORVET Complex Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion HOPS Complex Intracellular Protein Localization Protein Transport Intracellular Protein Transport Vesicle Tethering Complex Establishment Of Protein Localization Endosome To Lysosome Transport Mon1-Ccz1 Complex Clathrin-coated Vesicle Autophagosome Vesicle Fusion Organelle Membrane Fusion Lysosomal Transport Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Organelle Fusion Vesicle-mediated Transport Late Endosome Membrane Late Endosome Membrane Fusion Intracellular Transport Vacuole Organization Protein Localization To Organelle Cellular Localization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Establishment Of Localization In Cell Vesicle Docking Involved In Exocytosis Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Endosome Membrane Syntaxin Binding Autophagy Protein Targeting To Vacuole Vesicle Organization Early Endosome Vesicle Docking Establishment Of Protein Localization To Vacuole Lysosomal Membrane Organelle Localization By Membrane Tethering Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Endosome Organization Regulation Of Protein-containing Complex Assembly Membrane Docking Protein Localization To Vacuole Lysosome Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric Early Viral Transcription Vacuole Fusion, Non-autophagic	Protein Kinase A Binding Protein Binding Protein Kinase A Regulatory Subunit Binding
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