VPS33A

Description		VPS33A core subunit of CORVET and HOPS complexes
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GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Endosome Membrane Membrane AP-3 Adaptor Complex Clathrin-coated Vesicle HOPS Complex Cytoplasmic Vesicle Late Endosome Membrane CORVET Complex Perinuclear Region Of Cytoplasm Clathrin Complex
	Molecular Function	Protein Binding
	Biological Process	Intracellular Protein Transport Autophagy Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Platelet Formation Melanosome Localization Lysosome Localization Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Regulation Of Lysosomal Lumen PH Pigmentation Regulation Of Developmental Pigmentation Autophagosome Maturation
Pathways		SARS-CoV-2 modulates autophagy
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		7 interacting genes: MON1A MON1B ROPN1 TNKS VPS11 VPS16 VPS18
Entrez ID		65082
HPRD ID		15651
Ensembl ID		ENSG00000139719
Uniprot IDs		F5H6Y0 Q96AX1
PDB IDs		4BX8 4BX9
Enriched GO Terms of Interacting Partners?		Vacuolar Transport CORVET Complex Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion HOPS Complex Intracellular Protein Localization Protein Transport Intracellular Protein Transport Vesicle Tethering Complex Establishment Of Protein Localization Endosome To Lysosome Transport Mon1-Ccz1 Complex Clathrin-coated Vesicle Autophagosome Vesicle Fusion Organelle Membrane Fusion Lysosomal Transport Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Organelle Fusion Vesicle-mediated Transport Late Endosome Membrane Late Endosome Membrane Fusion Intracellular Transport Vacuole Organization Protein Localization To Organelle Cellular Localization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Establishment Of Localization In Cell Vesicle Docking Involved In Exocytosis Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Endosome Membrane Syntaxin Binding Autophagy Protein Targeting To Vacuole Vesicle Organization Early Endosome Vesicle Docking Establishment Of Protein Localization To Vacuole Lysosomal Membrane Organelle Localization By Membrane Tethering Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Endosome Organization Regulation Of Protein-containing Complex Assembly Membrane Docking Protein Localization To Vacuole Lysosome Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric Early Viral Transcription Vacuole Fusion, Non-autophagic
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