TMEM237 and INSIG1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM237	INSIG1
Description		transmembrane protein 237	insulin induced gene 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cilium Microtubule Cytoskeleton Membrane Nuclear Speck Photoreceptor Connecting Cilium Ciliary Transition Zone Cell Projection Cone Photoreceptor Outer Segment Rod Photoreceptor Outer Segment	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane SREBP-SCAP-Insig Complex
	Molecular Function	Protein Binding	Protein Binding Oxysterol Binding Lipid Binding Protein Sequestering Activity
	Biological Process	Cell Projection Organization Regulation Of Wnt Signaling Pathway Cilium Assembly	NLS-bearing Protein Import Into Nucleus Lipid Metabolic Process Triglyceride Metabolic Process Cholesterol Biosynthetic Process Response To Sterol Depletion Steroid Metabolic Process Cholesterol Metabolic Process Negative Regulation Of Steroid Biosynthetic Process Sterol Biosynthetic Process Cellular Response To Insulin Stimulus SREBP Signaling Pathway Cellular Response To Sterol SREBP-SCAP Complex Retention In Endoplasmic Reticulum Inner Ear Morphogenesis Middle Ear Morphogenesis Cholesterol Homeostasis Negative Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Protein Maturation Roof Of Mouth Development Cranial Suture Morphogenesis Negative Regulation Of Protein Exit From Endoplasmic Reticulum Negative Regulation Of Cargo Loading Into COPII-coated Vesicle
Pathways			Regulation of cholesterol biosynthesis by SREBP (SREBF)
Drugs
Diseases
GWAS		Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730)	Bladder cancer (smoking interaction) ( 24662972) Diverticular disease ( 30177863) Energy expenditure (24h) ( 28476931) Formal thought disorder in schizophrenia ( 22648509) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Plasma anti-thyroglobulin levels ( 29678681) Triiodothyronine levels and thyroxine levels ( 30843173)
Interacting Genes		123 interacting genes: ABHD16A ADAM33 ADIPOQ APOD APOL3 AQP1 ARLN ATP13A1 BET1 BLCAP BNIP2 BTN2A2 C1GALT1 C3orf52 CBLIF CCDC167 CD53 CDS1 CFHR5 CFTR CLDN4 CLN6 CNIH3 CTSA CXCL16 CXCL9 CYB5B EFNA5 EMC6 ERMP1 EXTL1 FBXO7 FKBP14 FXYD6 FZD7 GJB2 GKN2 GPR152 GPR25 GPR42 GRM2 GUCA2A GYPA IER3IP1 IFNGR1 IGFBP5 INSIG1 INSIG2 JAGN1 LAT LEPROTL1 LPAR3 LRP10 LTA MFF MFSD6 MS4A13 OPRD1 ORMDL3 OTOP2 OTOP3 PLPPR2 PNLIPRP1 POMGNT1 PRB1 PRNP RETREG3 RHD ROBO2 RPRM RUSF1 SEC22A SERP2 SERPINE1 SFXN5 SLC12A7 SLC16A4 SLC29A2 SLC2A5 SLC30A8 SLC35A4 SLC35B2 SLC35B4 SLC35E4 SLC35G1 SLC38A2 SLC38A7 SLC39A2 SLC39A9 SLC41A1 SLC41A2 SLC52A1 SLC5A4 SLC61A1 SLC7A1 SLC7A3 ST6GAL2 STRIT1 STX8 TLCD4 TM4SF19 TM6SF2 TMEFF2 TMEM107 TMEM11 TMEM128 TMEM144 TMEM147 TMEM179B TMEM201 TMEM254 TMEM42 TMEM60 TMEM72 TMEM86B TRARG1 UNC93A UNC93B1 UPK1B VAMP3 VEGFA YIPF6 ZFPL1	11 interacting genes: AQP6 BDKRB1 HMGCR HTR2B PCK1 PSMA7 PSMC3 SCAP SREBF2 TMEM237 VCP
Entrez ID		65062	3638
HPRD ID		12448	03633
Ensembl ID		ENSG00000155755	ENSG00000186480
Uniprot IDs		Q96Q45	A4D2M9 F5H6P3 O15503
PDB IDs			4J81
Enriched GO Terms of Interacting Partners?		Membrane Transmembrane Transport Endoplasmic Reticulum Endoplasmic Reticulum Membrane Protein Binding Chemical Homeostasis Plasma Membrane Transmembrane Transporter Activity Monoatomic Ion Transport Organic Anion Transport Inorganic Ion Transmembrane Transport Monoatomic Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Metal Ion Transport Monoatomic Cation Transport Homeostatic Process Monoatomic Cation Transmembrane Transport SREBP-SCAP-Insig Complex L-ornithine Transmembrane Transport L-ornithine Transmembrane Transporter Activity SNAP Receptor Activity Craniofacial Suture Morphogenesis Monoatomic Cation Transmembrane Transporter Activity Amino Acid Transport Regulation Of Smooth Muscle Cell-matrix Adhesion Carbohydrate Transmembrane Transport SREBP-SCAP Complex Retention In Endoplasmic Reticulum Ornithine Transport L-arginine Import Across Plasma Membrane Insulin Metabolic Process Carbohydrate Transport Retinal Ganglion Cell Axon Guidance Intracellular Chemical Homeostasis Transepithelial Water Transport Negative Regulation Of SREBP Signaling Pathway L-lysine Transmembrane Transporter Activity Zinc Ion Transmembrane Transporter Activity Cellular Response To CAMP Import Across Plasma Membrane L-lysine Transmembrane Transport Zinc Ion Transmembrane Transport	Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Steroid Biosynthetic Process Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Steroid Metabolic Process Regulation Of Cholesterol Metabolic Process Regulation Of Lipid Biosynthetic Process Proteasome Complex SREBP Signaling Pathway Cellular Response To Sterol Depletion Negative Regulation Of Amyloid-beta Clearance Regulation Of Steroid Biosynthetic Process Response To Sterol Depletion Alcohol Metabolic Process Regulation Of Steroid Metabolic Process Regulation Of Lipid Metabolic Process Regulation Of Small Molecule Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Regulation Of Amyloid-beta Clearance Endoplasmic Reticulum ER-nucleus Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Steroid Metabolic Process Modification-dependent Protein Catabolic Process Nitrate Transmembrane Transporter Activity Hydroxymethylglutaryl-CoA Reductase (NADPH) Activity Protein Serine Kinase Activity (using GTP As Donor) Flavin Adenine Dinucleotide Catabolic Process SREBP-SCAP Complex ER To Golgi Transport Vesicle Membrane Positive Regulation Of Biosynthetic Process Proteolysis Involved In Protein Catabolic Process PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Bradykinin Receptor Activity Phosphoenolpyruvate Carboxykinase (GTP) Activity Phosphoenolpyruvate Carboxykinase Activity Glycerol Biosynthetic Process From Pyruvate Propionate Catabolic Process C-8 Sterol Isomerase Activity VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination Response To Vitamin B3 Regulation Of Protein Catabolic Process Small Molecule Metabolic Process
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