TMEM237 and FZD7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM237	FZD7
Description		transmembrane protein 237	frizzled class receptor 7
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cilium Microtubule Cytoskeleton Membrane Nuclear Speck Photoreceptor Connecting Cilium Ciliary Transition Zone Cell Projection Cone Photoreceptor Outer Segment Rod Photoreceptor Outer Segment	Endosome Plasma Membrane Endosome Membrane Membrane Recycling Endosome Membrane
	Molecular Function	Protein Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Frizzled Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Wnt-protein Binding PDZ Domain Binding Wnt Receptor Activity
	Biological Process	Cell Projection Organization Regulation Of Wnt Signaling Pathway Cilium Assembly	Regulation Of DNA-templated Transcription Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell-substrate Adhesion Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Wnt Signaling Pathway Stem Cell Population Maintenance Neuron Differentiation T Cell Differentiation In Thymus Substrate Adhesion-dependent Cell Spreading Non-canonical Wnt Signaling Pathway Positive Regulation Of Phosphorylation Negative Regulation Of Ectodermal Cell Fate Specification Positive Regulation Of MAPK Cascade Positive Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Somatic Stem Cell Division Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Mesenchymal To Epithelial Transition Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Retinoic Acid Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways			Class B/2 (Secretin family receptors) PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping
Drugs
Diseases
GWAS		Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730)	Age at first sexual intercourse ( 34211149) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Blond vs. brown/black hair color ( 30531825) Heel bone mineral density ( 28869591 30598549) Metabolite levels ( 23823483) Risk-taking tendency (4-domain principal component model) ( 30643258) Total body bone mineral density ( 29304378)
Interacting Genes		123 interacting genes: ABHD16A ADAM33 ADIPOQ APOD APOL3 AQP1 ARLN ATP13A1 BET1 BLCAP BNIP2 BTN2A2 C1GALT1 C3orf52 CBLIF CCDC167 CD53 CDS1 CFHR5 CFTR CLDN4 CLN6 CNIH3 CTSA CXCL16 CXCL9 CYB5B EFNA5 EMC6 ERMP1 EXTL1 FBXO7 FKBP14 FXYD6 FZD7 GJB2 GKN2 GPR152 GPR25 GPR42 GRM2 GUCA2A GYPA IER3IP1 IFNGR1 IGFBP5 INSIG1 INSIG2 JAGN1 LAT LEPROTL1 LPAR3 LRP10 LTA MFF MFSD6 MS4A13 OPRD1 ORMDL3 OTOP2 OTOP3 PLPPR2 PNLIPRP1 POMGNT1 PRB1 PRNP RETREG3 RHD ROBO2 RPRM RUSF1 SEC22A SERP2 SERPINE1 SFXN5 SLC12A7 SLC16A4 SLC29A2 SLC2A5 SLC30A8 SLC35A4 SLC35B2 SLC35B4 SLC35E4 SLC35G1 SLC38A2 SLC38A7 SLC39A2 SLC39A9 SLC41A1 SLC41A2 SLC52A1 SLC5A4 SLC61A1 SLC7A1 SLC7A3 ST6GAL2 STRIT1 STX8 TLCD4 TM4SF19 TM6SF2 TMEFF2 TMEM107 TMEM11 TMEM128 TMEM144 TMEM147 TMEM179B TMEM201 TMEM254 TMEM42 TMEM60 TMEM72 TMEM86B TRARG1 UNC93A UNC93B1 UPK1B VAMP3 VEGFA YIPF6 ZFPL1	30 interacting genes: ADCY1 AIG1 AQP9 BCL2L13 CCDC88C CLN8 CLPTM1 DLG1 DLG2 DLG4 DVL1 FFAR2 GNAS HPCAL1 LEUTX MAGI3 MGST1 NCALD NCS1 PDAP1 PRNP PSME3IP1 SGTA SGTB SLC30A4 SLC35B1 TMEM237 UBQLN1 UBQLN2 UBQLN4
Entrez ID		65062	8324
HPRD ID		12448	04560
Ensembl ID		ENSG00000155755	ENSG00000155760
Uniprot IDs		Q96Q45	O75084
PDB IDs			4Z33 5T44 5URV 5WBS 6NE2 6NE4 6O3A 6O3B 8QEO 8YY8 9EPO 9EW2
Enriched GO Terms of Interacting Partners?		Membrane Transmembrane Transport Endoplasmic Reticulum Endoplasmic Reticulum Membrane Protein Binding Chemical Homeostasis Plasma Membrane Transmembrane Transporter Activity Monoatomic Ion Transport Organic Anion Transport Inorganic Ion Transmembrane Transport Monoatomic Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Metal Ion Transport Monoatomic Cation Transport Homeostatic Process Monoatomic Cation Transmembrane Transport SREBP-SCAP-Insig Complex L-ornithine Transmembrane Transport L-ornithine Transmembrane Transporter Activity SNAP Receptor Activity Craniofacial Suture Morphogenesis Monoatomic Cation Transmembrane Transporter Activity Amino Acid Transport Regulation Of Smooth Muscle Cell-matrix Adhesion Carbohydrate Transmembrane Transport SREBP-SCAP Complex Retention In Endoplasmic Reticulum Ornithine Transport L-arginine Import Across Plasma Membrane Insulin Metabolic Process Carbohydrate Transport Retinal Ganglion Cell Axon Guidance Intracellular Chemical Homeostasis Transepithelial Water Transport Negative Regulation Of SREBP Signaling Pathway L-lysine Transmembrane Transporter Activity Zinc Ion Transmembrane Transporter Activity Cellular Response To CAMP Import Across Plasma Membrane L-lysine Transmembrane Transport Zinc Ion Transmembrane Transport	Postsynaptic Density GMP Kinase Activity Ionotropic Glutamate Receptor Binding Regulation Of Proteolysis GDP Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Receptor Clustering TRC Complex Positive Regulation Of ERAD Pathway Membrane Ribonucleoside Diphosphate Metabolic Process Regulation Of ERAD Pathway Nucleoside Diphosphate Metabolic Process GMP Metabolic Process Dendritic Spine Organization Kinase Binding Frizzled Binding Postsynaptic Density Membrane Polyubiquitin Modification-dependent Protein Binding Regulation Of Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Neuron Projection Organization D1 Dopamine Receptor Binding Postsynapse Organization Plasma Membrane Positive Regulation Of Neuron Projection Arborization Receptor Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Establishment Or Maintenance Of Apical/basal Cell Polarity Negative Regulation Of Proteolysis Social Behavior Purine Ribonucleotide Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Protein Localization To Synapse Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Ribonucleotide Metabolic Process Establishment Or Maintenance Of Cell Polarity Juxtaparanode Region Of Axon Cytoplasmic Microtubule Organization Ribose Phosphate Metabolic Process Cognition Cellular Response To Metal Ion Immunological Synapse Formation Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Cellular Response To Potassium Ion Response To Metal Ion Nucleoside Monophosphate Metabolic Process
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