TMEM237 and GRM2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM237	GRM2
Description		transmembrane protein 237	glutamate metabotropic receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cilium Microtubule Cytoskeleton Membrane Nuclear Speck Photoreceptor Connecting Cilium Ciliary Transition Zone Cell Projection Cone Photoreceptor Outer Segment Rod Photoreceptor Outer Segment	Plasma Membrane Membrane Axon Dendrite Presynaptic Membrane Cell Projection Neuron Projection Synapse Postsynaptic Membrane Astrocyte Projection Glutamatergic Synapse
	Molecular Function	Protein Binding	Group II Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Calcium Channel Regulator Activity Protein Binding Glutamate Receptor Activity Scaffold Protein Binding
	Biological Process	Cell Projection Organization Regulation Of Wnt Signaling Pathway Cilium Assembly	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Gene Expression Glutamate Secretion Regulation Of Glutamate Secretion Regulation Of Dopamine Secretion Cellular Response To Stress Behavioral Response To Nicotine Response To Cocaine Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Depression Intracellular Glutamate Homeostasis Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Response To Drug
Pathways			G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs			LY2140023
Diseases
GWAS		Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730)
Interacting Genes		123 interacting genes: ABHD16A ADAM33 ADIPOQ APOD APOL3 AQP1 ARLN ATP13A1 BET1 BLCAP BNIP2 BTN2A2 C1GALT1 C3orf52 CBLIF CCDC167 CD53 CDS1 CFHR5 CFTR CLDN4 CLN6 CNIH3 CTSA CXCL16 CXCL9 CYB5B EFNA5 EMC6 ERMP1 EXTL1 FBXO7 FKBP14 FXYD6 FZD7 GJB2 GKN2 GPR152 GPR25 GPR42 GRM2 GUCA2A GYPA IER3IP1 IFNGR1 IGFBP5 INSIG1 INSIG2 JAGN1 LAT LEPROTL1 LPAR3 LRP10 LTA MFF MFSD6 MS4A13 OPRD1 ORMDL3 OTOP2 OTOP3 PLPPR2 PNLIPRP1 POMGNT1 PRB1 PRNP RETREG3 RHD ROBO2 RPRM RUSF1 SEC22A SERP2 SERPINE1 SFXN5 SLC12A7 SLC16A4 SLC29A2 SLC2A5 SLC30A8 SLC35A4 SLC35B2 SLC35B4 SLC35E4 SLC35G1 SLC38A2 SLC38A7 SLC39A2 SLC39A9 SLC41A1 SLC41A2 SLC52A1 SLC5A4 SLC61A1 SLC7A1 SLC7A3 ST6GAL2 STRIT1 STX8 TLCD4 TM4SF19 TM6SF2 TMEFF2 TMEM107 TMEM11 TMEM128 TMEM144 TMEM147 TMEM179B TMEM201 TMEM254 TMEM42 TMEM60 TMEM72 TMEM86B TRARG1 UNC93A UNC93B1 UPK1B VAMP3 VEGFA YIPF6 ZFPL1	31 interacting genes: ACBD5 ACE2 AQP6 BIK CCDC107 CLDN2 CLDN9 CPLX4 CYB5R3 GNA15 GNAQ GRIP1 LMNA MGST3 MMGT1 NAALADL2 PDZK1IP1 RGS12 SAR1A SDCBP SLC30A8 SLC38A1 SLC71A2 STOM TAMALIN TFRC TMEM130 TMEM237 TMEM248 TSPAN18 UBQLN1
Entrez ID		65062	2912
HPRD ID		12448	04977
Ensembl ID		ENSG00000155755	ENSG00000164082
Uniprot IDs		Q96Q45	H7BXL3 Q14416
PDB IDs			4XAQ 4XAS 5CNI 5CNJ 5KZN 5KZQ 7E9G 7EPA 7EPB 7EPD 7MTQ 7MTR 7MTS 8JCU 8JCV 8JCW 8JCX 8JCY 8JCZ 8JD0 8JD1 8JD2 8JD3 8JD4 8JD5 8WG9 8WGB 8WGC 8WGD
Enriched GO Terms of Interacting Partners?		Membrane Transmembrane Transport Endoplasmic Reticulum Endoplasmic Reticulum Membrane Protein Binding Chemical Homeostasis Plasma Membrane Transmembrane Transporter Activity Monoatomic Ion Transport Organic Anion Transport Inorganic Ion Transmembrane Transport Monoatomic Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Metal Ion Transport Monoatomic Cation Transport Homeostatic Process Monoatomic Cation Transmembrane Transport SREBP-SCAP-Insig Complex L-ornithine Transmembrane Transport L-ornithine Transmembrane Transporter Activity SNAP Receptor Activity Craniofacial Suture Morphogenesis Monoatomic Cation Transmembrane Transporter Activity Amino Acid Transport Regulation Of Smooth Muscle Cell-matrix Adhesion Carbohydrate Transmembrane Transport SREBP-SCAP Complex Retention In Endoplasmic Reticulum Ornithine Transport L-arginine Import Across Plasma Membrane Insulin Metabolic Process Carbohydrate Transport Retinal Ganglion Cell Axon Guidance Intracellular Chemical Homeostasis Transepithelial Water Transport Negative Regulation Of SREBP Signaling Pathway L-lysine Transmembrane Transporter Activity Zinc Ion Transmembrane Transporter Activity Cellular Response To CAMP Import Across Plasma Membrane L-lysine Transmembrane Transport Zinc Ion Transmembrane Transport	Membrane Plasma Membrane
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