TMEM237 and SLC38A2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM237	SLC38A2
Description		transmembrane protein 237	solute carrier family 38 member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cilium Microtubule Cytoskeleton Membrane Nuclear Speck Photoreceptor Connecting Cilium Ciliary Transition Zone Cell Projection Cone Photoreceptor Outer Segment Rod Photoreceptor Outer Segment	Cytoplasm Plasma Membrane Brush Border Membrane Axon Dendrite Sarcolemma Neuronal Cell Body
	Molecular Function	Protein Binding	Amino Acid:sodium Symporter Activity Neutral L-amino Acid:sodium Symporter Activity Proline:sodium Symporter Activity Protein Binding Amino Acid Transmembrane Transporter Activity Acidic Amino Acid Transmembrane Transporter Activity Neutral L-amino Acid Transmembrane Transporter Activity L-glutamine Transmembrane Transporter Activity L-serine Transmembrane Transporter Activity Symporter Activity Alanine:sodium Symporter Activity
	Biological Process	Cell Projection Organization Regulation Of Wnt Signaling Pathway Cilium Assembly	Amino Acid Transmembrane Transport Monoatomic Ion Transport Sodium Ion Transport Neurotransmitter Transport Amino Acid Transport Glutamine Transport Female Pregnancy Positive Regulation Of Gene Expression Response To Muscle Activity Acidic Amino Acid Transport Neutral Amino Acid Transport Proline Transport L-serine Transport Cerebral Cortex Development Glycine Betaine Transport Alanine Transport Positive Regulation Of RNA Splicing Cellular Response To Amino Acid Starvation Sodium Ion Transmembrane Transport Amino Acid Import Cellular Response To Mechanical Stimulus Regulation Of Cellular Response To Stress Transport Across Blood-brain Barrier Regulation Of Glutamate Secretion, Neurotransmission L-glutamine Import Across Plasma Membrane L-serine Import Across Plasma Membrane Cellular Response To Arsenite(3-) L-proline Import Across Plasma Membrane
Pathways			Glutamate Neurotransmitter Release Cycle Amino acid transport across the plasma membrane
Drugs			Asparagine
Diseases
GWAS		Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730)	Appendicular lean mass ( 33097823) Blond vs. brown/black hair color ( 30531825) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Uterine fibroids ( 31649266)
Interacting Genes		123 interacting genes: ABHD16A ADAM33 ADIPOQ APOD APOL3 AQP1 ARLN ATP13A1 BET1 BLCAP BNIP2 BTN2A2 C1GALT1 C3orf52 CBLIF CCDC167 CD53 CDS1 CFHR5 CFTR CLDN4 CLN6 CNIH3 CTSA CXCL16 CXCL9 CYB5B EFNA5 EMC6 ERMP1 EXTL1 FBXO7 FKBP14 FXYD6 FZD7 GJB2 GKN2 GPR152 GPR25 GPR42 GRM2 GUCA2A GYPA IER3IP1 IFNGR1 IGFBP5 INSIG1 INSIG2 JAGN1 LAT LEPROTL1 LPAR3 LRP10 LTA MFF MFSD6 MS4A13 OPRD1 ORMDL3 OTOP2 OTOP3 PLPPR2 PNLIPRP1 POMGNT1 PRB1 PRNP RETREG3 RHD ROBO2 RPRM RUSF1 SEC22A SERP2 SERPINE1 SFXN5 SLC12A7 SLC16A4 SLC29A2 SLC2A5 SLC30A8 SLC35A4 SLC35B2 SLC35B4 SLC35E4 SLC35G1 SLC38A2 SLC38A7 SLC39A2 SLC39A9 SLC41A1 SLC41A2 SLC52A1 SLC5A4 SLC61A1 SLC7A1 SLC7A3 ST6GAL2 STRIT1 STX8 TLCD4 TM4SF19 TM6SF2 TMEFF2 TMEM107 TMEM11 TMEM128 TMEM144 TMEM147 TMEM179B TMEM201 TMEM254 TMEM42 TMEM60 TMEM72 TMEM86B TRARG1 UNC93A UNC93B1 UPK1B VAMP3 VEGFA YIPF6 ZFPL1	4 interacting genes: APP DCDC2 STX11 TMEM237
Entrez ID		65062	54407
HPRD ID		12448	05535
Ensembl ID		ENSG00000155755	ENSG00000134294
Uniprot IDs		Q96Q45	Q8NHT5 Q96QD8
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Transmembrane Transport Endoplasmic Reticulum Endoplasmic Reticulum Membrane Protein Binding Chemical Homeostasis Plasma Membrane Transmembrane Transporter Activity Monoatomic Ion Transport Organic Anion Transport Inorganic Ion Transmembrane Transport Monoatomic Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Metal Ion Transport Monoatomic Cation Transport Homeostatic Process Monoatomic Cation Transmembrane Transport SREBP-SCAP-Insig Complex L-ornithine Transmembrane Transport L-ornithine Transmembrane Transporter Activity SNAP Receptor Activity Craniofacial Suture Morphogenesis Monoatomic Cation Transmembrane Transporter Activity Amino Acid Transport Regulation Of Smooth Muscle Cell-matrix Adhesion Carbohydrate Transmembrane Transport SREBP-SCAP Complex Retention In Endoplasmic Reticulum Ornithine Transport L-arginine Import Across Plasma Membrane Insulin Metabolic Process Carbohydrate Transport Retinal Ganglion Cell Axon Guidance Intracellular Chemical Homeostasis Transepithelial Water Transport Negative Regulation Of SREBP Signaling Pathway L-lysine Transmembrane Transporter Activity Zinc Ion Transmembrane Transporter Activity Cellular Response To CAMP Import Across Plasma Membrane L-lysine Transmembrane Transport Zinc Ion Transmembrane Transport	Regulation Of Wnt Signaling Pathway Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Plasma Membrane Bounded Cell Projection Organization Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Cell Projection Organization Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Neuron Projection Morphogenesis Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Cell Projection Cilium Assembly Cell Projection Morphogenesis Axon Choice Point Recognition Cone Photoreceptor Outer Segment Cilium Organization Heparan Sulfate Binding Signaling Receptor Activator Activity Kinocilium Peptidase Activator Activity Cellular Response To Manganese Ion Rod Photoreceptor Outer Segment Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Antifungal Humoral Response Nuclear Envelope Lumen
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