TMEM237 and IFNGR1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM237	IFNGR1
Description		transmembrane protein 237	interferon gamma receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cilium Microtubule Cytoskeleton Membrane Nuclear Speck Photoreceptor Connecting Cilium Ciliary Transition Zone Cell Projection Cone Photoreceptor Outer Segment Rod Photoreceptor Outer Segment	Plasma Membrane Membrane
	Molecular Function	Protein Binding	Cytokine Receptor Activity Type II Interferon Receptor Activity Protein Binding Cytokine Binding
	Biological Process	Cell Projection Organization Regulation Of Wnt Signaling Pathway Cilium Assembly	Microglial Cell Activation Immune System Process Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Virus Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Type III Interferon-mediated Signaling Pathway Astrocyte Activation Defense Response To Virus Type II Interferon-mediated Signaling Pathway Defense Response To Other Organism Cellular Response To Virus Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Formation
Pathways			Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Potential therapeutics for SARS IFNG signaling activates MAPKs
Drugs			Interferon gamma-1b
Diseases			Tuberculosis IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS		Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730)	Behcet's disease ( 33393726) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cognitive performance (processing speed) ( 31598132)
Interacting Genes		123 interacting genes: ABHD16A ADAM33 ADIPOQ APOD APOL3 AQP1 ARLN ATP13A1 BET1 BLCAP BNIP2 BTN2A2 C1GALT1 C3orf52 CBLIF CCDC167 CD53 CDS1 CFHR5 CFTR CLDN4 CLN6 CNIH3 CTSA CXCL16 CXCL9 CYB5B EFNA5 EMC6 ERMP1 EXTL1 FBXO7 FKBP14 FXYD6 FZD7 GJB2 GKN2 GPR152 GPR25 GPR42 GRM2 GUCA2A GYPA IER3IP1 IFNGR1 IGFBP5 INSIG1 INSIG2 JAGN1 LAT LEPROTL1 LPAR3 LRP10 LTA MFF MFSD6 MS4A13 OPRD1 ORMDL3 OTOP2 OTOP3 PLPPR2 PNLIPRP1 POMGNT1 PRB1 PRNP RETREG3 RHD ROBO2 RPRM RUSF1 SEC22A SERP2 SERPINE1 SFXN5 SLC12A7 SLC16A4 SLC29A2 SLC2A5 SLC30A8 SLC35A4 SLC35B2 SLC35B4 SLC35E4 SLC35G1 SLC38A2 SLC38A7 SLC39A2 SLC39A9 SLC41A1 SLC41A2 SLC52A1 SLC5A4 SLC61A1 SLC7A1 SLC7A3 ST6GAL2 STRIT1 STX8 TLCD4 TM4SF19 TM6SF2 TMEFF2 TMEM107 TMEM11 TMEM128 TMEM144 TMEM147 TMEM179B TMEM201 TMEM254 TMEM42 TMEM60 TMEM72 TMEM86B TRARG1 UNC93A UNC93B1 UPK1B VAMP3 VEGFA YIPF6 ZFPL1	15 interacting genes: AQP6 CANX IFNG IFNGR2 JAK1 JAK2 NINJ2 PTPN11 RAC1 RUSF1 SOCS1 STAT1 STIM1 TMEM100 TMEM237
Entrez ID		65062	3459
HPRD ID		12448	00127
Ensembl ID		ENSG00000155755	ENSG00000027697
Uniprot IDs		Q96Q45	A0A0S2Z3Y2 A0A2R8Y4U4 A0A2R8YFL3 P15260
PDB IDs			1FG9 1FYH 1JRH 6E3K 6E3L
Enriched GO Terms of Interacting Partners?		Membrane Transmembrane Transport Endoplasmic Reticulum Endoplasmic Reticulum Membrane Protein Binding Chemical Homeostasis Plasma Membrane Transmembrane Transporter Activity Monoatomic Ion Transport Organic Anion Transport Inorganic Ion Transmembrane Transport Monoatomic Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Metal Ion Transport Monoatomic Cation Transport Homeostatic Process Monoatomic Cation Transmembrane Transport SREBP-SCAP-Insig Complex L-ornithine Transmembrane Transport L-ornithine Transmembrane Transporter Activity SNAP Receptor Activity Craniofacial Suture Morphogenesis Monoatomic Cation Transmembrane Transporter Activity Amino Acid Transport Regulation Of Smooth Muscle Cell-matrix Adhesion Carbohydrate Transmembrane Transport SREBP-SCAP Complex Retention In Endoplasmic Reticulum Ornithine Transport L-arginine Import Across Plasma Membrane Insulin Metabolic Process Carbohydrate Transport Retinal Ganglion Cell Axon Guidance Intracellular Chemical Homeostasis Transepithelial Water Transport Negative Regulation Of SREBP Signaling Pathway L-lysine Transmembrane Transporter Activity Zinc Ion Transmembrane Transporter Activity Cellular Response To CAMP Import Across Plasma Membrane L-lysine Transmembrane Transport Zinc Ion Transmembrane Transport	Type II Interferon-mediated Signaling Pathway Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Cytokine-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Regulation Of Receptor Signaling Pathway Via JAK-STAT Cellular Response To Virus Positive Regulation Of Developmental Process Cell Surface Receptor Signaling Pathway Microglial Cell Activation Positive Regulation Of Cell Adhesion Leukocyte Activation Involved In Inflammatory Response Positive Regulation Of Nitric Oxide Biosynthetic Process Myeloid Leukocyte Activation Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Cell-cell Adhesion Regulation Of Developmental Process Regulation Of Epithelial Cell Differentiation Regulation Of Insulin Secretion Regulation Of Multicellular Organismal Development Enzyme-linked Receptor Protein Signaling Pathway Response To Virus Interleukin-9-mediated Signaling Pathway CCR5 Chemokine Receptor Binding Interleukin-7-mediated Signaling Pathway Macrophage Activation Regulation Of Peptide Hormone Secretion Regulation Of Cell Differentiation Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Interleukin-23 Production Growth Hormone Receptor Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Alpha-beta T Cell Activation Peptide Hormone Receptor Binding Interleukin-2-mediated Signaling Pathway Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Cell Adhesion Regulation Of Cytokine Production Regulation Of Multicellular Organismal Process Positive Regulation Of Transport Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Myeloid Cell Differentiation Regulation Of Cell-cell Adhesion Regulation Of Hormone Secretion Cell Differentiation Positive Regulation Of MHC Class II Biosynthetic Process
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