SIPA1 and RFWD2

Number of citations of the paper that reports this interaction (PMID 11461903)
35

Data Source:
HPRD (two hybrid, in vitro)

		SIPA1	RFWD2
Gene Name		signal-induced proliferation-associated 1	ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Golgi Apparatus Cytosol Plasma Membrane Transport Vesicle Protein Complex Perinuclear Region Of Cytoplasm	Golgi Membrane Nucleoplasm Cytoplasm Centrosome Cytosol Focal Adhesion Nuclear Speck
	Molecular Function	GTPase Activator Activity Protein Binding Protein C-terminus Binding Rap GTPase Activator Activity	Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Cytoskeleton Organization Negative Regulation Of Cell Adhesion Signal Transduction Cell Proliferation Negative Regulation Of Cell Growth Positive Regulation Of Rap GTPase Activity Intracellular Signal Transduction Cellular Response To Water Deprivation Positive Regulation Of GTPase Activity Negative Regulation Of Cell Cycle	DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Response To Ionizing Radiation Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways		Rap1 signalling Adaptive Immune System	p53-Dependent G1 DNA Damage Response Autodegradation of the E3 ubiquitin ligase COP1 Stabilization of p53 Cell Cycle Checkpoints p53-Dependent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CDKN1A DVL1 RFWD2	14 interactors: CCT4 DET1 ETS1 ETS2 JUN JUND PTPN1 RB1CC1 SFN SIPA1 TP53 UBE2D1 UBE2D2 YWHAZ
Entrez ID		6494	64326
HPRD ID		03713	07455
Ensembl ID		ENSG00000213445	ENSG00000143207
Uniprot IDs		F6RY50 Q96FS4	Q05CT6 Q8NHY2
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Signal Transduction By P53 Class Mediator Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Response To Ionizing Radiation Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Positive Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Kinase Activity Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Negative Regulation Of Kinase Activity Convergent Extension Involved In Neural Plate Elongation Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Intracellular Signal Transduction Negative Regulation Of Protein Phosphorylation Collateral Sprouting Intestinal Epithelial Cell Maturation Regulation Of Cellular Protein Metabolic Process Convergent Extension Involved In Organogenesis Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Phosphorylation	Cellular Response To Stress Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Release Of Cytochrome C From Mitochondria Response To Abiotic Stimulus Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Stress Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Transcription From RNA Polymerase II Promoter Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Mitochondrion Organization Cellular Response To Extracellular Stimulus Regulation Of Cell Cycle TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Apoptotic Mitochondrial Changes Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Response To Hypoxia Regulation Of Mitochondrion Organization Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hypoxia Intracellular Signal Transduction Cellular Response To Decreased Oxygen Levels Response To Wounding Regulation Of Cellular Component Organization Toll-like Receptor Signaling Pathway Apoptotic Signaling Pathway Cellular Response To Oxygen Levels Cellular Response To Stimulus Mitochondrion Organization Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Immune System Process Cellular Response To Starvation Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Innate Immune Response Regulation Of Apoptotic Process Organelle Organization RNA Metabolic Process Transcription, DNA-templated Negative Regulation Of Cell Cycle Negative Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Response To Endoplasmic Reticulum Stress Negative Regulation Of Programmed Cell Death Response To Extracellular Stimulus
Tagcloud ?		1307t allele arms chi confer conferred ecm extra genotype genotyping hyderabad insilco institute know modifier modulates nizam online polymorphism processing1 reconfirmed rrp1b rrp1b1307 rrp1b1307tt rs9306160 rural sciences tt urban
Tagcloud (Difference) ?		1307t allele arms chi confer conferred ecm extra genotype genotyping hyderabad insilco institute know modifier modulates nizam online polymorphism processing1 reconfirmed rrp1b rrp1b1307 rrp1b1307tt rs9306160 rural sciences tt urban
Tagcloud (Intersection) ?