SIPA1

Description		signal-induced proliferation-associated 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Endomembrane System Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Activator Activity Protein Binding
	Biological Process	Adaptive Immune Response Cytoskeleton Organization Negative Regulation Of Cell Adhesion Signal Transduction Negative Regulation Of Cell Growth Intracellular Signal Transduction Cellular Response To Water Deprivation Negative Regulation Of Cell Cycle Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Rap1 signalling
Drugs
Diseases
GWAS		A body shape index ( 34021172) Acne (severe) ( 24927181) Asthma ( 31619474) Coronary artery disease ( 33020668) Diastolic blood pressure ( 27841878) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) HDL cholesterol ( 30275531) Hip circumference adjusted for BMI ( 34021172) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Metabolic syndrome ( 31589552) Platelet count ( 27863252) Pulse pressure ( 30578418) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systolic blood pressure ( 27618452 30578418 27841878) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		4 interacting genes: CDKN1A COP1 DVL1 SHANK3
Entrez ID		6494
HPRD ID		03713
Ensembl ID		ENSG00000213445
Uniprot IDs		Q96FS4
PDB IDs
Enriched GO Terms of Interacting Partners?		Dendritic Spine Morphogenesis Positive Regulation Of Excitatory Postsynaptic Potential Receptor Clustering Neuron Projection Organization Modulation Of Excitatory Postsynaptic Potential Social Behavior Dendritic Spine Organization Postsynapse Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Response To Ionizing Radiation Positive Regulation Of Protein Localization To Presynapse Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Postsynapse Organization Regulation Of Nervous System Process Dendritic Spine Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Guanylate Kinase-associated Protein Clustering Protein Localization To Nucleus Convergent Extension Involved In Neural Plate Elongation Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Cell-matrix Adhesion Positive Regulation Of Protein Catabolic Process Synaptic Receptor Adaptor Activity Convergent Extension Involved In Organogenesis Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Postsynaptic Density Synapse Organization Neuron Projection Morphogenesis Convergent Extension Involved In Gastrulation Positive Regulation Of Protein Localization To Synapse Oncogene-induced Cell Senescence Stress-induced Premature Senescence Cell Projection Morphogenesis Postsynaptic Density Assembly Regulation Of Synapse Structural Plasticity Positive Regulation Of Neuron Projection Arborization Regulation Of Synapse Organization Protein Localization To Membrane Vocal Learning
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