ST3GAL3 and ACTG1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ST3GAL3	ACTG1
Description		ST3 beta-galactoside alpha-2,3-sialyltransferase 3	actin gamma 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Golgi Apparatus Membrane Golgi Cisterna Membrane	Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Myofibril Axon Filamentous Actin NuA4 Histone Acetyltransferase Complex Apical Junction Complex Calyx Of Held Apical Part Of Cell Synapse Phagocytic Vesicle Extracellular Exosome Blood Microparticle Dense Body Schaffer Collateral - CA1 Synapse Basal Body Patch
	Molecular Function	Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity Protein Binding N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity Sialyltransferase Activity Transferase Activity Glycosyltransferase Activity	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding Profilin Binding ATP Binding Hydrolase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton
	Biological Process	Protein Glycosylation Glycosphingolipid Biosynthetic Process Oligosaccharide Biosynthetic Process Ganglioside Biosynthetic Process Via Lactosylceramide Protein O-linked Glycosylation Via N-acetyl-galactosamine Keratan Sulfate Proteoglycan Biosynthetic Process Viral Protein Processing	Angiogenesis Morphogenesis Of A Polarized Epithelium Axonogenesis Positive Regulation Of Gene Expression Positive Regulation Of Cell Migration Maintenance Of Blood-brain Barrier Sarcomere Organization Cell Motility Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Platelet Aggregation Cellular Response To Type II Interferon Positive Regulation Of Wound Healing Postsynaptic Actin Cytoskeleton Organization Tight Junction Assembly Regulation Of Transepithelial Transport Regulation Of Synaptic Vesicle Endocytosis Protein Localization To Bicellular Tight Junction
Pathways		Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Defective ST3GAL3 causes MCT12 and EIEE15 Sialic acid metabolism Lewis blood group biosynthesis Maturation of protein 3a Maturation of spike protein Maturation of protein 3a Termination of O-glycan biosynthesis Glycosphingolipid biosynthesis	Translocation of SLC2A4 (GLUT4) to the plasma membrane Gap junction degradation Formation of annular gap junctions Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells Adherens junctions interactions Adherens junctions interactions Recycling pathway of L1 Recycling pathway of L1 VEGFA-VEGFR2 Pathway Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Cell-extracellular matrix interactions RHO GTPases activate IQGAPs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Clathrin-mediated endocytosis RHOBTB2 GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs			Copper Artenimol
Diseases		Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS		Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Aging (time to event) ( 21782286) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Attention deficit hyperactivity disorder ( 29325848) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) General cognitive ability ( 29844566) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Left-handedness ( 32989287) Monocyte percentage of white cells ( 32888494) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Refractive error ( 32231278) Schizophrenia ( 28991256) Serum alkaline phosphatase levels ( 33547301)	Alanine aminotransferase levels ( 33339817 33547301) Gamma glutamyl transferase levels ( 33339817) Hand grip strength ( 29313844) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Refractive error ( 32231278)
Interacting Genes		5 interacting genes: ACTG1 RPL8 SCAMP2 TTR ZBTB5	72 interacting genes: ABLIM1 ACTB ANXA5 ATF7IP BCAP31 BIN1 BRCA1 CAP1 CAP2 CAPZA3 CCDC22 CDC37 CDKN2A CEBPA CFL1 CFL2 COTL1 CTBP2 CTTN CYBB DISC1 DNASE1 DSTN DUX4 DYNLL1 EHHADH EIF6 FHOD1 FNDC3B FPR1 GIT2 GSN GZMA GZMK HRAS HSPB2 LGALS13 LIG4 LINC00941 LINC01554 LSP1 MAP1A MAPK6 MAPT MCPH1 MYO1A MYOC NDRG1 NR3C2 NTAQ1 PFN2 PLD1 PLEC PPP1R9A PRSS23 PSEN2 PTPRO RPS6KA5 SCIN SH3GL2 SRPK2 ST3GAL3 SUMO4 TMSB4X TMSB4Y TNIK VASP VIL1 WASF1 WASL WEE2-AS1 WIPF1
Entrez ID		6487	71
HPRD ID		05930	00017
Ensembl ID		ENSG00000126091	ENSG00000184009
Uniprot IDs		A0A2R8Y6H4 A0A2R8Y6L4 A0A2R8Y732 A0A2R8YDJ6 Q11203	P63261
PDB IDs			5JLH 6CXI 6CXJ 6G2T 6V62 6V63 6WK1 6WK2 7NVM 8DNF
Enriched GO Terms of Interacting Partners?			Actin Binding Actin Filament Organization Actin Filament-based Process Regulation Of Actin Filament Organization Supramolecular Fiber Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Actin Cytoskeleton Positive Regulation Of Cytoskeleton Organization Actin Polymerization Or Depolymerization Actin Filament Binding Cytoskeleton Actin Cytoskeleton Organization Regulation Of Cellular Component Size Regulation Of Actin Filament Polymerization Regulation Of Organelle Organization Actin Filament Severing Cytoskeleton Organization Regulation Of Cellular Component Organization Positive Regulation Of Organelle Organization Actin Filament Depolymerization Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Actin Filament Depolymerization Cortical Actin Cytoskeleton Regulation Of Protein Depolymerization Lamellipodium Cell Projection Organization Cytoplasm Modification Of Postsynaptic Structure Positive Regulation Of Cellular Component Organization Modification Of Synaptic Structure Regulation Of Protein-containing Complex Disassembly Glutamatergic Synapse Positive Regulation Of Actin Filament Depolymerization Regulation Of Protein-containing Complex Assembly Negative Regulation Of Cytoskeleton Organization Actin Filament Fragmentation Protein Depolymerization Organelle Organization Plasma Membrane Bounded Cell Projection Organization Presynapse Negative Regulation Of Actin Filament Depolymerization Positive Regulation Of Protein Depolymerization Barbed-end Actin Filament Capping Positive Regulation Of Cellular Component Biogenesis
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