ST3GAL3

Name	ST3 beta-galactoside alpha-2,3-sialyltransferase 3
Structure	No pdb structure
Novel Interactors	14 novel interactors: CAVIN2 EIF2B3 FBLN5 HDAC5 KCNQ4 KDM4A LASP1 MOB3B NASP PIK3R3 POU3F1 RRM2 TGFB1I1 VTI1A
Interactors	5 interactors: ACTG1 RPL8 SCAMP2 TTR ZBTB5
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Golgi Apparatus Membrane Golgi Cisterna Membrane
	Molecular Function	Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity Protein Binding N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity Sialyltransferase Activity Transferase Activity Glycosyltransferase Activity
	Biological Process	Protein Glycosylation Glycosphingolipid Biosynthetic Process Oligosaccharide Biosynthetic Process Ganglioside Biosynthetic Process Via Lactosylceramide Protein O-linked Glycosylation Via N-acetyl-galactosamine Keratan Sulfate Proteoglycan Biosynthetic Process Viral Protein Processing
Pathways	Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Defective ST3GAL3 causes MCT12 and EIEE15 Sialic acid metabolism Lewis blood group biosynthesis Maturation of protein 3a Maturation of spike protein Maturation of protein 3a Termination of O-glycan biosynthesis Glycosphingolipid biosynthesis
Diseases	Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS	Age at first birth ( 34211149 ) Age at first sexual intercourse ( 34211149 ) Aging (time to event) ( 21782286 ) Amyotrophic lateral sclerosis (age of onset) ( 22959728 ) Attention deficit hyperactivity disorder ( 29325848 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Cognitive ability ( 29186694 ) Cognitive ability (MTAG) ( 29186694 ) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444 ) General cognitive ability ( 29844566 ) Household income ( 31844048 ) Household income (MTAG) ( 31844048 ) Intelligence (MTAG) ( 29326435 ) Left-handedness ( 32989287 ) Monocyte percentage of white cells ( 32888494 ) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377 ) Refractive error ( 32231278 ) Schizophrenia ( 28991256 ) Serum alkaline phosphatase levels ( 33547301 )
Entrez ID	6487
HPRD ID	05930
Ensembl ID	ENSG00000126091
Uniprot IDs	A0A2R8Y6H4 A0A2R8Y6L4 A0A2R8Y732 A0A2R8YDJ6 Q11203
PDB IDs	Not available