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ST3GAL3
Gene Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Extracellular Region
Integral Component Of Golgi Membrane
Golgi Cisterna Membrane
Molecular Function
Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity
N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity
Biological Process
Carbohydrate Metabolic Process
Dolichol-linked Oligosaccharide Biosynthetic Process
Protein O-linked Glycosylation
Pathogenesis
O-glycan Processing
Keratan Sulfate Biosynthetic Process
Protein N-linked Glycosylation Via Asparagine
Glycosaminoglycan Metabolic Process
Keratan Sulfate Metabolic Process
Post-translational Protein Modification
Cellular Protein Metabolic Process
Small Molecule Metabolic Process
Sialylation
Pathways
Keratan sulfate/keratin metabolism
MPS I - Hurler syndrome
MPS IX - Natowicz syndrome
Glycosaminoglycan metabolism
Defective MGAT2 causes MGAT2-CDG (CDG-2a)
O-linked glycosylation
Defective CHST14 causes EDS, musculocontractural type
Myoclonic epilepsy of Lafora
MPS IIID - Sanfilippo syndrome D
Defective CHST6 causes MCDC1
Glycogen storage diseases
Defective ALG2 causes ALG2-CDG (CDG-1i)
Keratan sulfate biosynthesis
Diseases associated with glycosaminoglycan metabolism
Mucopolysaccharidoses
Defective ALG3 causes ALG3-CDG (CDG-1d)
Post-translational protein modification
Defective EXT2 causes exostoses 2
Signaling by NOTCH
Termination of O-glycan biosynthesis
Synthesis of substrates in N-glycan biosythesis
Asparagine N-linked glycosylation
MPS IV - Morquio syndrome A
Sialic acid metabolism
Defective MPDU1 causes MPDU1-CDG (CDG-1f)
Metabolism of carbohydrates
O-linked glycosylation of mucins
Diseases associated with N-glycosylation of proteins
MPS VI - Maroteaux-Lamy syndrome
MPS IIIB - Sanfilippo syndrome B
Diseases of glycosylation
Defective B4GALT7 causes EDS, progeroid type
Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
Defective SLC26A2 causes chondrodysplasias
Defective ALG1 causes ALG1-CDG (CDG-1k)
Defective MOGS causes MOGS-CDG (CDG-2b)
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective ALG9 causes ALG9-CDG (CDG-1l)
Defective PAPSS2 causes SEMD-PA
Defective MAN1B1 causes MRT15
MPS IIIA - Sanfilippo syndrome A
Pre-NOTCH Expression and Processing
Defective ALG11 causes ALG11-CDG (CDG-1p)
MPS IIIC - Sanfilippo syndrome C
Pre-NOTCH Processing in Golgi
Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
MPS II - Hunter syndrome
Defective CHST3 causes SEDCJD
Defective B3GAT3 causes JDSSDHD
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Defective RFT1 causes RFT1-CDG (CDG-1n)
Defective ALG6 causes ALG6-CDG (CDG-1c)
Defective ALG8 causes ALG8-CDG (CDG-1h)
Defective ALG12 causes ALG12-CDG (CDG-1g)
Defective CHSY1 causes TPBS
MPS IV - Morquio syndrome B
MPS VII - Sly syndrome
Drugs
Diseases
GWAS
Aging (time to event) (
21782286
)
Amyotrophic lateral sclerosis (age of onset) (
22959728
)
Protein-protein Interactions
5 interactors:
ACTG1
RPL8
SCAMP2
TTR
ZBTB5
Entrez ID
6487
HPRD ID
05930
Ensembl ID
ENSG00000126091
Uniprot IDs
B4DX62
Q11203
PDB IDs
Enriched GO Terms of Interacting Partners
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