PORCN and APOC4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PORCN	APOC4
Description		porcupine O-acyltransferase	apolipoprotein C4
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane AMPA Glutamate Receptor Complex Glutamatergic Synapse	Extracellular Region Very-low-density Lipoprotein Particle High-density Lipoprotein Particle
	Molecular Function	Protein Binding Transferase Activity Acyltransferase Activity Wnt-protein Binding Palmitoleoyltransferase Activity	Lipid Transporter Activity Protein Binding
	Biological Process	Protein Lipidation Glycoprotein Metabolic Process Wnt Signaling Pathway Lipid Modification Protein Palmitoleylation Wnt Protein Secretion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	Lipid Metabolic Process Lipid Transport Lipid Storage Triglyceride Homeostasis
Pathways		WNT ligand biogenesis and trafficking LGK974 inhibits PORCN	VLDL assembly VLDL clearance VLDL clearance NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases		Focal dermal hypoplasia; Goltz-Gorlin syndrome
GWAS			Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) HDL cholesterol levels ( 32203549) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 20864672 19060906 18802019 18193044 18193043) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Quantitative traits ( 19197348) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		9 interacting genes: APOC2 APOC4 CBARP WNT1 WNT3A WNT4 WNT5B WNT6 WNT7B	24 interacting genes: APOL2 BCL2L2 DIABLO GAD2 GSDMA IFI27 LETMD1 MAIP1 MICOS10 MICOS13 NFU1 PORCN RSAD2 SENP2 SNAP47 SYT16 TBC1D20 THBD TIMMDC1 TMEM14B TPRG1 UBQLN1 UBQLN2 VKORC1
Entrez ID		64840	346
HPRD ID		06680	02848
Ensembl ID		ENSG00000102312	ENSG00000267467
Uniprot IDs		Q9H237	P55056
PDB IDs		7URA 7URC 7URD 7URE
Enriched GO Terms of Interacting Partners?		Frizzled Binding Endocytic Vesicle Membrane Golgi Lumen Canonical Wnt Signaling Pathway Positive Regulation Of Dermatome Development Cell Fate Commitment Cytokine Activity Wnt Signaling Pathway Endoplasmic Reticulum Lumen Neuron Differentiation Signaling Receptor Binding Cellular Response To Retinoic Acid Positive Regulation Of Embryonic Development Response To Retinoic Acid Extracellular Region Receptor Ligand Activity Tissue Morphogenesis Extracellular Space Branching Involved In Ureteric Bud Morphogenesis Non-canonical Wnt Signaling Pathway Cell Proliferation In Midbrain Kidney Epithelium Development Lens Fiber Cell Development Cell Surface Regulation Of Embryonic Development Tube Morphogenesis Spinal Cord Association Neuron Differentiation Mammary Gland Epithelium Development Positive Regulation Of Developmental Process Morphogenesis Of An Epithelium Midbrain Dopaminergic Neuron Differentiation Muscle Cell Differentiation Kidney Morphogenesis Pattern Specification Process Fat Cell Differentiation Branching Morphogenesis Of An Epithelial Tube Cellular Response To Oxygen-containing Compound Regulation Of Fat Cell Differentiation Central Nervous System Neuron Differentiation Very-low-density Lipoprotein Particle Morphogenesis Of A Branching Epithelium Nephron Tubule Development Cellular Response To Lipid High-density Lipoprotein Particle Morphogenesis Of A Branching Structure Embryonic Epithelial Tube Formation Renal Tubule Development Midbrain Development Epithelial Tube Formation Dopaminergic Neuron Differentiation	Virion Assembly Membrane Mitochondrion Mitochondrion Organization Mitochondrial Inner Membrane Inner Mitochondrial Membrane Organization MICOS Complex Mitochondrial Crista Junction SAM Complex MIB Complex Host-mediated Perturbation Of Viral Genome Replication Mitochondrial Membrane Cristae Formation Host-mediated Perturbation Of Viral Process Mitochondrial Outer Membrane Negative Regulation Of Platelet Activation Positive Regulation Of ERAD Pathway Mitochondrial Calcium Ion Homeostasis Host-mediated Perturbation Of Symbiont Process Mitochondrial Membrane Organization Modulation Of Process Of Another Organism Extrinsic Apoptotic Signaling Pathway Regulation Of ERAD Pathway Negative Regulation Of Phospholipid Efflux Lipoprotein Metabolic Process Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Host-mediated Activation Of Viral Process Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Positive Regulation Of Coagulation Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Store-operated Calcium Channel Activity Palmitoleoyltransferase Activity Protein Palmitoleylation Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Positive Regulation Of Response To Endoplasmic Reticulum Stress Pyroptotic Inflammatory Response 4 Iron, 4 Sulfur Cluster Binding Organelle Organization Negative Regulation Of Coagulation Negative Regulation Of Blood Coagulation Positive Regulation Of Presynaptic Membrane Organization Chylomicron Remnant Lipid Transport Involved In Lipid Storage Lipoprotein Particle Protein Binding Regulation Of Platelet Activation
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