PORCN and WNT4

Number of citations of the paper that reports this interaction (PMID 10866835)
18

Data Source:
HPRD (in vivo, in vitro)

		PORCN	WNT4
Gene Name		porcupine homolog (Drosophila)	wingless-type MMTV integration site family, member 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface
	Molecular Function	Transferase Activity, Transferring Acyl Groups	Transcription Corepressor Activity Frizzled Binding Receptor Agonist Activity
	Biological Process	Glycoprotein Metabolic Process Wnt Signaling Pathway	Branching Involved In Ureteric Bud Morphogenesis Kidney Development Epithelial To Mesenchymal Transition Embryonic Epithelial Tube Formation Liver Development Androgen Biosynthetic Process Male Gonad Development Female Gonad Development Cellular Response To Starvation Negative Regulation Of Gene Expression Negative Regulation Of Steroid Biosynthetic Process Protein Palmitoylation Regulation Of Cell-cell Adhesion Neuron Differentiation Female Sex Determination Adrenal Gland Development Negative Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Positive Regulation Of Rho GTPase Activity Positive Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Collagen Biosynthetic Process Immature T Cell Proliferation In Thymus Non-canonical Wnt Signaling Pathway Via MAPK Cascade Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Cell Fate Commitment Negative Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Meiotic Nuclear Division Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Oocyte Development Smooth Muscle Cell Differentiation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Canonical Wnt Signaling Pathway Somatotropin Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Mesenchymal To Epithelial Transition Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Negative Regulation Of Wound Healing Mammary Gland Epithelium Development Positive Regulation Of Dermatome Development Paramesonephric Duct Development Negative Regulation Of Testicular Blood Vessel Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Renal Vesicle Formation Renal Vesicle Induction Metanephric Mesenchymal Cell Differentiation Metanephric Tubule Formation Metanephric Nephron Morphogenesis Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Male Gonad Development Positive Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Testosterone Biosynthetic Process Negative Regulation Of Apoptotic Signaling Pathway
Pathways		WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 Signaling by Wnt Signaling by WNT in cancer WNT ligand biogenesis and trafficking	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling negative regulation of TCF-dependent signaling by WNT ligand antagonists Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes WNT ligand biogenesis and trafficking beta-catenin independent WNT signaling WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer PCP/CE pathway Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS			Bone mineral density ( 22504420) Dupuytren's disease ( 21732829) Endometriosis ( 23104006 23472165 20601957) Obesity-related traits ( 23251661)
Protein-Protein Interactions		6 interactors: WNT1 WNT3A WNT4 WNT5B WNT6 WNT7B	6 interactors: APP FZD6 P2RX4 PORCN SFRP1 SFRP2
Entrez ID		64840	54361
HPRD ID		06680	04601
Ensembl ID		ENSG00000102312	ENSG00000162552
Uniprot IDs		B7ZAR3 Q9H237	B4DJF9 P56705
PDB IDs
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Cell Fate Commitment Positive Regulation Of Dermatome Development Cellular Response To Retinoic Acid Canonical Wnt Signaling Pathway Renal Tubule Development Kidney Morphogenesis Epithelial Tube Morphogenesis Epithelium Development Response To Retinoic Acid Tube Morphogenesis Neuron Differentiation Nephron Development Morphogenesis Of An Epithelium Kidney Epithelium Development Cellular Response To Acid Chemical Positive Regulation Of Embryonic Development Sensory Organ Development Branching Morphogenesis Of An Epithelial Tube Embryonic Morphogenesis Generation Of Neurons Tissue Morphogenesis Positive Regulation Of Receptor Activity Regulation Of Canonical Wnt Signaling Pathway Neurogenesis Tube Development Morphogenesis Of A Branching Epithelium Tissue Development Morphogenesis Of A Branching Structure Cellular Response To Organic Substance Branching Involved In Ureteric Bud Morphogenesis Regulation Of Wnt Signaling Pathway Kidney Development Ureteric Bud Morphogenesis Muscle Cell Differentiation Renal System Development Nephron Morphogenesis Organ Morphogenesis Renal Tubule Morphogenesis Nervous System Development Urogenital System Development Stem Cell Proliferation Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of Signal Transduction Cellular Response To Lipid Embryo Development Response To Organic Substance Negative Regulation Of Signaling Forebrain Development Regulation Of Embryonic Development	Wnt Signaling Pathway, Planar Cell Polarity Pathway Non-canonical Wnt Signaling Pathway Negative Regulation Of Planar Cell Polarity Pathway Involved In Axis Elongation Wnt Signaling Pathway Cellular Response To X-ray Convergent Extension Involved In Axis Elongation Wnt Signaling Pathway Involved In Somitogenesis Neural Tube Closure Neural Tube Formation Negative Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of JUN Kinase Activity Planar Cell Polarity Pathway Involved In Neural Tube Closure Developmental Growth Involved In Morphogenesis Embryonic Epithelial Tube Formation Epithelial Tube Formation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Convergent Extension Cell Surface Receptor Signaling Pathway Tube Formation Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Morphogenesis Of Embryonic Epithelium Regulation Of Organ Morphogenesis Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Wnt Signaling Pathway Neural Tube Development Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Canonical Wnt Signaling Pathway Response To X-ray Negative Regulation Of JNK Cascade Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Stress-activated MAPK Cascade Developmental Growth Axis Elongation Regulation Of Developmental Growth Regulation Of Wnt Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Cell Development Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Fat Cell Differentiation Epithelial Tube Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Regulation Of Cellular Amino Acid Metabolic Process Cellular Response To Ionizing Radiation Tube Morphogenesis Regulation Of Signal Transduction Signal Transduction Digestive Tract Morphogenesis Response To Radiation
Tagcloud ?		accessible annotation autosomes bcor chromosome embryonic entire es establishing hemizygous http humans ibme lethal mutagenic mutational null phenotypes publicly retardation screen screens syntenic technologies trapped utoronto website xlinkedgenes xlmr	abcb1b administrated brosis colla1 corroborated dkk1 dkk2 dkk3 dkk4 fi frizzled frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt2 wnt3 wnt5a wnt6 wnt7a wnt9a
Tagcloud (Difference) ?		accessible annotation autosomes bcor chromosome embryonic entire es establishing hemizygous http humans ibme lethal mutagenic mutational null phenotypes publicly retardation screen screens syntenic technologies trapped utoronto website xlinkedgenes xlmr	abcb1b administrated brosis colla1 corroborated dkk1 dkk2 dkk3 dkk4 fi frizzled frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt2 wnt3 wnt5a wnt6 wnt7a wnt9a
Tagcloud (Intersection) ?