PORCN and WNT6

Number of citations of the paper that reports this interaction (PubMedID 10866835)
0

Data Source:
HPRD (in vitro, in vivo)

		PORCN	WNT6
Description		porcupine O-acyltransferase	Wnt family member 6
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane AMPA Glutamate Receptor Complex Glutamatergic Synapse	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Endocytic Vesicle Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	Protein Binding Transferase Activity Acyltransferase Activity Wnt-protein Binding Palmitoleoyltransferase Activity	Signaling Receptor Binding Frizzled Binding Cytokine Activity
	Biological Process	Protein Lipidation Glycoprotein Metabolic Process Wnt Signaling Pathway Lipid Modification Protein Palmitoleylation Wnt Protein Secretion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	Branching Involved In Ureteric Bud Morphogenesis Axis Specification Positive Regulation Of Gene Expression Wnt Signaling Pathway Neuron Differentiation Odontogenesis Of Dentin-containing Tooth Cell Fate Commitment Positive Regulation Of DNA-templated Transcription Canonical Wnt Signaling Pathway Epithelial-mesenchymal Cell Signaling Cornea Development In Camera-type Eye Positive Regulation Of Tooth Mineralization Cellular Response To Retinoic Acid Nephron Tubule Formation Nephron Tubule Development
Pathways		WNT ligand biogenesis and trafficking LGK974 inhibits PORCN	WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)
Drugs
Diseases		Focal dermal hypoplasia; Goltz-Gorlin syndrome
GWAS			Height ( 31562340) High density lipoprotein cholesterol levels ( 33339817) Male-pattern baldness ( 28196072) Reticulocyte count ( 32888494) Triglyceride levels ( 33339817)
Interacting Genes		9 interacting genes: APOC2 APOC4 CBARP WNT1 WNT3A WNT4 WNT5B WNT6 WNT7B	2 interacting genes: PORCN RHOU
Entrez ID		64840	7475
HPRD ID		06680	05233
Ensembl ID		ENSG00000102312	ENSG00000115596
Uniprot IDs		Q9H237	Q8N2E5 Q9Y6F9
PDB IDs		7URA 7URC 7URD 7URE
Enriched GO Terms of Interacting Partners?		Frizzled Binding Endocytic Vesicle Membrane Golgi Lumen Canonical Wnt Signaling Pathway Positive Regulation Of Dermatome Development Cell Fate Commitment Cytokine Activity Wnt Signaling Pathway Endoplasmic Reticulum Lumen Neuron Differentiation Signaling Receptor Binding Cellular Response To Retinoic Acid Positive Regulation Of Embryonic Development Response To Retinoic Acid Extracellular Region Receptor Ligand Activity Tissue Morphogenesis Extracellular Space Branching Involved In Ureteric Bud Morphogenesis Non-canonical Wnt Signaling Pathway Cell Proliferation In Midbrain Kidney Epithelium Development Lens Fiber Cell Development Cell Surface Regulation Of Embryonic Development Tube Morphogenesis Spinal Cord Association Neuron Differentiation Mammary Gland Epithelium Development Positive Regulation Of Developmental Process Morphogenesis Of An Epithelium Midbrain Dopaminergic Neuron Differentiation Muscle Cell Differentiation Kidney Morphogenesis Pattern Specification Process Fat Cell Differentiation Branching Morphogenesis Of An Epithelial Tube Cellular Response To Oxygen-containing Compound Regulation Of Fat Cell Differentiation Central Nervous System Neuron Differentiation Very-low-density Lipoprotein Particle Morphogenesis Of A Branching Epithelium Nephron Tubule Development Cellular Response To Lipid High-density Lipoprotein Particle Morphogenesis Of A Branching Structure Embryonic Epithelial Tube Formation Renal Tubule Development Midbrain Development Epithelial Tube Formation Dopaminergic Neuron Differentiation	Palmitoleoyltransferase Activity Protein Palmitoleylation Wnt Protein Secretion GTP Binding Positive Regulation Of Focal Adhesion Disassembly Protein Kinase Binding
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