PORCN and CBARP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PORCN	CBARP
Description		porcupine O-acyltransferase	CACN subunit beta associated regulatory protein
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane AMPA Glutamate Receptor Complex Glutamatergic Synapse	Plasma Membrane Membrane Secretory Granule Growth Cone Synaptic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Synapse
	Molecular Function	Protein Binding Transferase Activity Acyltransferase Activity Wnt-protein Binding Palmitoleoyltransferase Activity	Protein Binding Transmembrane Transporter Binding
	Biological Process	Protein Lipidation Glycoprotein Metabolic Process Wnt Signaling Pathway Lipid Modification Protein Palmitoleylation Wnt Protein Secretion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	Negative Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Calcium Ion Transmembrane Transport
Pathways		WNT ligand biogenesis and trafficking LGK974 inhibits PORCN
Drugs
Diseases		Focal dermal hypoplasia; Goltz-Gorlin syndrome
GWAS
Interacting Genes		9 interacting genes: APOC2 APOC4 CBARP WNT1 WNT3A WNT4 WNT5B WNT6 WNT7B	10 interacting genes: ABHD16A ATP13A1 CALHM6 MS4A13 NCK2 PORCN SLC35F6 SLC39A9 SLC61A1 TRAF3IP3
Entrez ID		64840	255057
HPRD ID		06680	16627
Ensembl ID		ENSG00000102312	ENSG00000099625
Uniprot IDs		Q9H237	Q8N350
PDB IDs		7URA 7URC 7URD 7URE
Enriched GO Terms of Interacting Partners?		Frizzled Binding Endocytic Vesicle Membrane Golgi Lumen Canonical Wnt Signaling Pathway Positive Regulation Of Dermatome Development Cell Fate Commitment Cytokine Activity Wnt Signaling Pathway Endoplasmic Reticulum Lumen Neuron Differentiation Signaling Receptor Binding Cellular Response To Retinoic Acid Positive Regulation Of Embryonic Development Response To Retinoic Acid Extracellular Region Receptor Ligand Activity Tissue Morphogenesis Extracellular Space Branching Involved In Ureteric Bud Morphogenesis Non-canonical Wnt Signaling Pathway Cell Proliferation In Midbrain Kidney Epithelium Development Lens Fiber Cell Development Cell Surface Regulation Of Embryonic Development Tube Morphogenesis Spinal Cord Association Neuron Differentiation Mammary Gland Epithelium Development Positive Regulation Of Developmental Process Morphogenesis Of An Epithelium Midbrain Dopaminergic Neuron Differentiation Muscle Cell Differentiation Kidney Morphogenesis Pattern Specification Process Fat Cell Differentiation Branching Morphogenesis Of An Epithelial Tube Cellular Response To Oxygen-containing Compound Regulation Of Fat Cell Differentiation Central Nervous System Neuron Differentiation Very-low-density Lipoprotein Particle Morphogenesis Of A Branching Epithelium Nephron Tubule Development Cellular Response To Lipid High-density Lipoprotein Particle Morphogenesis Of A Branching Structure Embryonic Epithelial Tube Formation Renal Tubule Development Midbrain Development Epithelial Tube Formation Dopaminergic Neuron Differentiation	Extraction Of Mislocalized Protein From ER Membrane ABC-type Manganese Transporter Activity Membrane Protein Dislocase Activity Palmitoleoyltransferase Activity Protein Palmitoleylation Molybdate Ion Transmembrane Transporter Activity Molybdate Ion Transport Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Regulation Of Cellular Response To Testosterone Stimulus Zinc Efflux Transmembrane Transporter Activity Wnt Protein Secretion Monoatomic Ion Transport Membrane P-type Transmembrane Transporter Activity Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress P-type Ion Transporter Activity Voltage-gated Channel Activity Monoacylglycerol Catabolic Process Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Transmembrane Transport Androgen Binding
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