PORCN and WNT7B

Number of citations: 0 (PubMedID 10866835)
Data Source: HPRD (in vitro, in vivo)

		PORCN	WNT7B
Name		porcupine O-acyltransferase	Wnt family member 7B
Structure			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane AMPA Glutamate Receptor Complex Glutamatergic Synapse	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Endocytic Vesicle Membrane Extracellular Exosome
	Molecular Function	Protein Binding Transferase Activity Acyltransferase Activity Wnt-protein Binding Palmitoleoyltransferase Activity	Signaling Receptor Binding Frizzled Binding Cytokine Activity Protein Binding Receptor Ligand Activity
	Biological Process	Protein Lipidation Glycoprotein Metabolic Process Wnt Signaling Pathway Lipid Modification Protein Palmitoleylation Wnt Protein Secretion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	In Utero Embryonic Development Metanephros Morphogenesis Tissue Development Wnt Signaling Pathway Establishment Or Maintenance Of Polarity Of Embryonic Epithelium Forebrain Regionalization Central Nervous System Vasculogenesis Cell Differentiation Neuron Differentiation Lung Development Neuron Projection Development Intracellular Oxygen Homeostasis Regulation Of Cell Projection Size Chemoattraction Of Dopaminergic Neuron Axon Homeostatic Process Cell Fate Commitment Positive Regulation Of Osteoblast Differentiation Positive Regulation Of JNK Cascade Fibroblast Proliferation Animal Organ Development Embryonic Organ Development System Development Neuron Projection Morphogenesis Synapse Organization Response To Glucocorticoid Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Lung Morphogenesis Lung Epithelium Development Lobar Bronchus Development Trachea Cartilage Morphogenesis Developmental Growth Involved In Morphogenesis Embryonic Placenta Morphogenesis Chorio-allantoic Fusion Mammary Gland Epithelium Development Lens Fiber Cell Development Cellular Response To Retinoic Acid Renal Inner Medulla Development Renal Outer Medulla Development Outer Medullary Collecting Duct Development Inner Medullary Collecting Duct Development Stem Cell Proliferation Metanephric Collecting Duct Development Metanephric Epithelium Development Metanephric Loop Of Henle Development
Pathways		WNT ligand biogenesis and trafficking LGK974 inhibits PORCN	WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)
Diseases		Focal dermal hypoplasia; Goltz-Gorlin syndrome	None
GWAS		No GWAS studies recorded	Appendicular lean mass ( 33097823 ) Body mass index ( 25760438 ) Central corneal thickness ( 28171582 29847655 ) Corneal curvature ( 25823570 ) Dupuytren's disease ( 28886342 21732829 ) Heel bone mineral density ( 30598549 ) Hematocrit ( 27863252 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin concentration ( 27863252 ) Hemoglobin levels ( 32327693 ) Macular thickness ( 30535121 ) Optic disc size ( 31809533 ) Pancreas volume ( 34128465 ) Red blood cell count ( 32888494 27863252 ) Refractive error ( 32231278 ) Rosacea symptom severity ( 29771307 ) Type 2 diabetes ( 32499647 )
Novel Interactors		None recorded	1 novel interactors: PRR5
Interacting Genes		9 interacting genes: APOC2 APOC4 CBARP WNT1 WNT3A WNT4 WNT5B WNT6 WNT7B	5 interacting genes: CASK CUL3 ELOC GPC3 PORCN
Entrez ID		64840	7477
HPRD ID		06680	03573
Ensembl ID		ENSG00000102312	ENSG00000188064
Uniprot IDs		Q9H237	A8K0G1 P56706
PDB IDs		7URA 7URC 7URD 7URE	Not available
GO Terms Enriched among Interactors		Frizzled Binding Endocytic Vesicle Membrane Golgi Lumen Canonical Wnt Signaling Pathway Positive Regulation Of Dermatome Development Cell Fate Commitment Cytokine Activity Wnt Signaling Pathway Endoplasmic Reticulum Lumen Neuron Differentiation Signaling Receptor Binding Cellular Response To Retinoic Acid Positive Regulation Of Embryonic Development Response To Retinoic Acid Extracellular Region Receptor Ligand Activity Tissue Morphogenesis Extracellular Space Branching Involved In Ureteric Bud Morphogenesis Non-canonical Wnt Signaling Pathway Cell Proliferation In Midbrain Kidney Epithelium Development Lens Fiber Cell Development Cell Surface Regulation Of Embryonic Development Tube Morphogenesis Spinal Cord Association Neuron Differentiation Mammary Gland Epithelium Development Positive Regulation Of Developmental Process Morphogenesis Of An Epithelium Midbrain Dopaminergic Neuron Differentiation Muscle Cell Differentiation Kidney Morphogenesis Pattern Specification Process Fat Cell Differentiation Branching Morphogenesis Of An Epithelial Tube Cellular Response To Oxygen-containing Compound Regulation Of Fat Cell Differentiation Central Nervous System Neuron Differentiation Very-low-density Lipoprotein Particle Morphogenesis Of A Branching Epithelium Nephron Tubule Development Cellular Response To Lipid High-density Lipoprotein Particle Morphogenesis Of A Branching Structure Embryonic Epithelial Tube Formation Renal Tubule Development Midbrain Development Epithelial Tube Formation Dopaminergic Neuron Differentiation	Wnt Signaling Pathway Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Peptidyl-dipeptidase Inhibitor Activity Trophectodermal Cellular Morphogenesis Liver Morphogenesis Wnt Protein Secretion Palmitoleoyltransferase Activity Protein Palmitoleylation