PORCN and WNT7B

Number of citations of the paper that reports this interaction (PMID 10866835)
18

Data Source:
HPRD (in vitro, in vivo)

		PORCN	WNT7B
Gene Name		porcupine homolog (Drosophila)	wingless-type MMTV integration site family, member 7B
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane
	Molecular Function	Transferase Activity, Transferring Acyl Groups	Frizzled Binding
	Biological Process	Glycoprotein Metabolic Process Wnt Signaling Pathway	In Utero Embryonic Development Metanephros Morphogenesis Activation Of JUN Kinase Activity Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Wnt Signaling Pathway Establishment Or Maintenance Of Polarity Of Embryonic Epithelium Forebrain Regionalization Central Nervous System Vasculogenesis Neuron Differentiation Lung Development Oxygen Homeostasis Regulation Of Cell Projection Size Odontogenesis Of Dentin-containing Tooth Homeostatic Process Cellular Metabolic Process Cell Fate Commitment Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of JNK Cascade Fibroblast Proliferation Embryonic Organ Development Neuron Projection Morphogenesis Synapse Organization Smooth Muscle Cell Differentiation Response To Glucocorticoid Anatomical Structure Regression Canonical Wnt Signaling Pathway Lung Morphogenesis Lung Epithelium Development Lobar Bronchus Development Lung-associated Mesenchyme Development Trachea Cartilage Morphogenesis Developmental Growth Involved In Morphogenesis Embryonic Placenta Morphogenesis Chorio-allantoic Fusion Mammary Gland Epithelium Development Lens Fiber Cell Development Cellular Response To Retinoic Acid Renal Inner Medulla Development Renal Outer Medulla Development Outer Medullary Collecting Duct Development Inner Medullary Collecting Duct Development Stem Cell Proliferation Metanephric Collecting Duct Development Metanephric Epithelium Development Metanephric Loop Of Henle Development Apoptotic Process Involved In Patterning Of Blood Vessels
Pathways		WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 Signaling by Wnt Signaling by WNT in cancer WNT ligand biogenesis and trafficking	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 Signaling by Wnt Signaling by WNT in cancer Metabolic disorders of biological oxidation enzymes GPCR ligand binding WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS			Dupuytren's disease ( 21732829)
Protein-Protein Interactions		6 interactors: WNT1 WNT3A WNT4 WNT5B WNT6 WNT7B	5 interactors: CASK CUL3 GPC3 PORCN TCEB1
Entrez ID		64840	7477
HPRD ID		06680	03573
Ensembl ID		ENSG00000102312	ENSG00000188064
Uniprot IDs		B7ZAR3 Q9H237	A8K0G1 P56706
PDB IDs
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Cell Fate Commitment Positive Regulation Of Dermatome Development Cellular Response To Retinoic Acid Canonical Wnt Signaling Pathway Renal Tubule Development Kidney Morphogenesis Epithelial Tube Morphogenesis Epithelium Development Response To Retinoic Acid Tube Morphogenesis Neuron Differentiation Nephron Development Morphogenesis Of An Epithelium Kidney Epithelium Development Cellular Response To Acid Chemical Positive Regulation Of Embryonic Development Sensory Organ Development Branching Morphogenesis Of An Epithelial Tube Embryonic Morphogenesis Generation Of Neurons Tissue Morphogenesis Positive Regulation Of Receptor Activity Regulation Of Canonical Wnt Signaling Pathway Neurogenesis Tube Development Morphogenesis Of A Branching Epithelium Tissue Development Morphogenesis Of A Branching Structure Cellular Response To Organic Substance Branching Involved In Ureteric Bud Morphogenesis Regulation Of Wnt Signaling Pathway Kidney Development Ureteric Bud Morphogenesis Muscle Cell Differentiation Renal System Development Nephron Morphogenesis Organ Morphogenesis Renal Tubule Morphogenesis Nervous System Development Urogenital System Development Stem Cell Proliferation Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of Signal Transduction Cellular Response To Lipid Embryo Development Response To Organic Substance Negative Regulation Of Signaling Forebrain Development Regulation Of Embryonic Development	Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Trophectodermal Cellular Morphogenesis Negative Regulation Of Wnt Signaling Pathway Protein Metabolic Process Mesonephric Duct Morphogenesis Positive Regulation Of Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Wnt Signaling Pathway Regulation Of Epithelial Cell Proliferation Positive Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Wnt Signaling Pathway Mesonephric Duct Development Nephric Duct Morphogenesis Positive Regulation Of Metabolic Process Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Cell Proliferation Cell Proliferation Involved In Metanephros Development Positive Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Keratinocyte Proliferation Regulation Of Protein Catabolic Process Embryonic Cleavage Positive Regulation Of Calcium Ion Import Stress Fiber Assembly Cell Proliferation Involved In Kidney Development Coronary Vasculature Development Positive Regulation Of Chromosome Segregation Glycoprotein Metabolic Process Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Mesenchymal Cell Proliferation Catabolic Process Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter COPII Vesicle Coating Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Keratinocyte Proliferation COPII-coated Vesicle Budding Regulation Of Calcium Ion Import Negative Regulation Of Rho Protein Signal Transduction Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Protein Catabolic Process Trophectodermal Cell Differentiation Mitotic Metaphase Plate Congression Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of DNA-templated Transcription, Elongation Vesicle Targeting, To, From Or Within Golgi Protein Catabolic Process
Tagcloud ?		accessible annotation autosomes bcor chromosome embryonic entire es establishing hemizygous http humans ibme lethal mutagenic mutational null phenotypes publicly retardation screen screens syntenic technologies trapped utoronto website xlinkedgenes xlmr	acta2 amscs architectural cd105 cd73 cd90 chondrogenic confluence confluent cyto eng fibroblastic hinfp nes npat nt5e pou5f1 renewing rnaseq sfrp2 sfrp4 successively thy1 versatility wisp2 wnt2 wnt2b wnt5a wnt5b
Tagcloud (Difference) ?		accessible annotation autosomes bcor chromosome embryonic entire es establishing hemizygous http humans ibme lethal mutagenic mutational null phenotypes publicly retardation screen screens syntenic technologies trapped utoronto website xlinkedgenes xlmr	acta2 amscs architectural cd105 cd73 cd90 chondrogenic confluence confluent cyto eng fibroblastic hinfp nes npat nt5e pou5f1 renewing rnaseq sfrp2 sfrp4 successively thy1 versatility wisp2 wnt2 wnt2b wnt5a wnt5b
Tagcloud (Intersection) ?