PORCN and WNT3A

Number of citations of the paper that reports this interaction (PMID 10866835)
18

Data Source:
HPRD (in vitro, in vivo)

		PORCN	WNT3A
Gene Name		porcupine homolog (Drosophila)	wingless-type MMTV integration site family, member 3A
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Early Endosome Membrane
	Molecular Function	Transferase Activity, Transferring Acyl Groups	Transcription Coactivator Activity Frizzled Binding Frizzled-2 Binding Protein Binding Protein Domain Specific Binding Receptor Agonist Activity
	Biological Process	Glycoprotein Metabolic Process Wnt Signaling Pathway	Osteoblast Differentiation In Utero Embryonic Development Positive Regulation Of Protein Phosphorylation Heart Looping Positive Regulation Of Receptor Internalization Negative Regulation Of Heart Induction By Canonical Wnt Signaling Pathway Axon Guidance Positive Regulation Of Cell Proliferation COP9 Signalosome Assembly Negative Regulation Of Neuron Projection Development Spinal Cord Association Neuron Differentiation Hippocampus Development Cell Proliferation In Forebrain Wnt Signaling Pathway Involved In Forebrain Neuroblast Division Dorsal/ventral Neural Tube Patterning Hemopoiesis Neuron Differentiation Extracellular Matrix Organization Mammary Gland Development Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein Binding Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Protein Localization Positive Regulation Of Catenin Import Into Nucleus Skeletal Muscle Cell Differentiation Post-anal Tail Morphogenesis Inner Ear Morphogenesis Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Mesodermal Cell Fate Specification Paraxial Mesodermal Cell Fate Commitment Positive Regulation Of Collateral Sprouting In Absence Of Injury Negative Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Neurogenesis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Palate Development Canonical Wnt Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Dermatome Development Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment Regulation Of Microtubule Cytoskeleton Organization Platelet Aggregation Cellular Response To Retinoic Acid Negative Regulation Of Canonical Wnt Signaling Pathway Axis Elongation Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Canonical Wnt Signaling Pathway Involved In Controlling Type B Pancreatic Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways		WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 Signaling by Wnt Signaling by WNT in cancer WNT ligand biogenesis and trafficking	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling negative regulation of TCF-dependent signaling by WNT ligand antagonists Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes WNT ligand biogenesis and trafficking disassembly of the destruction complex and recruitment of AXIN to the membrane WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 TCF dependent signaling in response to WNT regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: WNT1 WNT3A WNT4 WNT5B WNT6 WNT7B	11 interactors: DLG1 DLG2 DLG4 FZD1 GPC3 LRP1 LRP6 PORCN RYK WNT1 WNT2
Entrez ID		64840	89780
HPRD ID		06680	05897
Ensembl ID		ENSG00000102312	ENSG00000154342
Uniprot IDs		B7ZAR3 Q9H237	P56704
PDB IDs
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Cell Fate Commitment Positive Regulation Of Dermatome Development Cellular Response To Retinoic Acid Canonical Wnt Signaling Pathway Renal Tubule Development Kidney Morphogenesis Epithelial Tube Morphogenesis Epithelium Development Response To Retinoic Acid Tube Morphogenesis Neuron Differentiation Nephron Development Morphogenesis Of An Epithelium Kidney Epithelium Development Cellular Response To Acid Chemical Positive Regulation Of Embryonic Development Sensory Organ Development Branching Morphogenesis Of An Epithelial Tube Embryonic Morphogenesis Generation Of Neurons Tissue Morphogenesis Positive Regulation Of Receptor Activity Regulation Of Canonical Wnt Signaling Pathway Neurogenesis Tube Development Morphogenesis Of A Branching Epithelium Tissue Development Morphogenesis Of A Branching Structure Cellular Response To Organic Substance Branching Involved In Ureteric Bud Morphogenesis Regulation Of Wnt Signaling Pathway Kidney Development Ureteric Bud Morphogenesis Muscle Cell Differentiation Renal System Development Nephron Morphogenesis Organ Morphogenesis Renal Tubule Morphogenesis Nervous System Development Urogenital System Development Stem Cell Proliferation Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of Signal Transduction Cellular Response To Lipid Embryo Development Response To Organic Substance Negative Regulation Of Signaling Forebrain Development Regulation Of Embryonic Development	Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Receptor Localization To Synapse Positive Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Cell-cell Signaling Protein Localization To Synapse Anatomical Structure Morphogenesis Canonical Wnt Signaling Pathway Neuron Differentiation Signaling Tissue Morphogenesis Regulation Of Embryonic Development Cell Communication Regulation Of Signal Transduction Positive Regulation Of Canonical Wnt Signaling Pathway System Development Regulation Of Signaling Nervous System Development Multicellular Organismal Development Anatomical Structure Development Negative Regulation Of Wnt Signaling Pathway Generation Of Neurons Receptor Clustering Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neurogenesis Nucleotide Phosphorylation Organ Morphogenesis Branching Involved In Ureteric Bud Morphogenesis Hard Palate Development Signal Transduction Morphogenesis Of A Branching Epithelium Epithelium Development Ureteric Bud Morphogenesis Negative Regulation Of Signal Transduction Morphogenesis Of A Branching Structure Developmental Process Negative Regulation Of Signaling Nephron Morphogenesis Renal Tubule Morphogenesis Regulation Of Epithelial Cell Proliferation Regulation Of BMP Signaling Pathway Stem Cell Proliferation Positive Regulation Of Signal Transduction Response To Stimulus Tube Development Cell Morphogenesis Involved In Differentiation Renal Tubule Development Cell Proliferation
Tagcloud ?		accessible annotation autosomes bcor chromosome embryonic entire es establishing hemizygous http humans ibme lethal mutagenic mutational null phenotypes publicly retardation screen screens syntenic technologies trapped utoronto website xlinkedgenes xlmr	122c 2012cb944901 9qh azoospermia blimp1 dazl ddx4 declare dppa3 envisioned fam122c funds grants hef ikbkg ipsc ipscs lin28 poi poi1 poi2 prdm1 q26 rbmx stella sublines talents vasa xq znf
Tagcloud (Difference) ?		accessible annotation autosomes bcor chromosome embryonic entire es establishing hemizygous http humans ibme lethal mutagenic mutational null phenotypes publicly retardation screen screens syntenic technologies trapped utoronto website xlinkedgenes xlmr	122c 2012cb944901 9qh azoospermia blimp1 dazl ddx4 declare dppa3 envisioned fam122c funds grants hef ikbkg ipsc ipscs lin28 poi poi1 poi2 prdm1 q26 rbmx stella sublines talents vasa xq znf
Tagcloud (Intersection) ?