PORCN and WNT5B

Number of citations of the paper that reports this interaction (PMID 10866835)
18

Data Source:
HPRD (in vitro, in vivo)

		PORCN	WNT5B
Gene Name		porcupine homolog (Drosophila)	wingless-type MMTV integration site family, member 5B
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Extracellular Vesicular Exosome
	Molecular Function	Transferase Activity, Transferring Acyl Groups	Receptor Binding Frizzled Binding
	Biological Process	Glycoprotein Metabolic Process Wnt Signaling Pathway	Chondrocyte Differentiation Wnt Signaling Pathway Neuron Differentiation Positive Regulation Of Cell Migration Wound Healing Cell Fate Commitment Fat Cell Differentiation Positive Regulation Of Fat Cell Differentiation Lens Fiber Cell Development Cellular Response To Retinoic Acid Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 Signaling by Wnt Signaling by WNT in cancer WNT ligand biogenesis and trafficking	WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 Signaling by Wnt Signaling by WNT in cancer WNT ligand biogenesis and trafficking PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: WNT1 WNT3A WNT4 WNT5B WNT6 WNT7B	2 interactors: APPBP2 PORCN
Entrez ID		64840	81029
HPRD ID		06680	05899
Ensembl ID		ENSG00000102312	ENSG00000111186
Uniprot IDs		B7ZAR3 Q9H237	Q9H1J7
PDB IDs
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Cell Fate Commitment Positive Regulation Of Dermatome Development Cellular Response To Retinoic Acid Canonical Wnt Signaling Pathway Renal Tubule Development Kidney Morphogenesis Epithelial Tube Morphogenesis Epithelium Development Response To Retinoic Acid Tube Morphogenesis Neuron Differentiation Nephron Development Morphogenesis Of An Epithelium Kidney Epithelium Development Cellular Response To Acid Chemical Positive Regulation Of Embryonic Development Sensory Organ Development Branching Morphogenesis Of An Epithelial Tube Embryonic Morphogenesis Generation Of Neurons Tissue Morphogenesis Positive Regulation Of Receptor Activity Regulation Of Canonical Wnt Signaling Pathway Neurogenesis Tube Development Morphogenesis Of A Branching Epithelium Tissue Development Morphogenesis Of A Branching Structure Cellular Response To Organic Substance Branching Involved In Ureteric Bud Morphogenesis Regulation Of Wnt Signaling Pathway Kidney Development Ureteric Bud Morphogenesis Muscle Cell Differentiation Renal System Development Nephron Morphogenesis Organ Morphogenesis Renal Tubule Morphogenesis Nervous System Development Urogenital System Development Stem Cell Proliferation Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of Signal Transduction Cellular Response To Lipid Embryo Development Response To Organic Substance Negative Regulation Of Signaling Forebrain Development Regulation Of Embryonic Development
Tagcloud ?		accessible annotation autosomes bcor chromosome embryonic entire es establishing hemizygous http humans ibme lethal mutagenic mutational null phenotypes publicly retardation screen screens syntenic technologies trapped utoronto website xlinkedgenes xlmr	acta2 amscs architectural cd105 cd73 cd90 chondrogenic confluence confluent cyto eng fibroblastic hinfp nes npat nt5e pou5f1 renewing rnaseq sfrp2 sfrp4 successively thy1 versatility wisp2 wnt2 wnt2b wnt5a wnt7b
Tagcloud (Difference) ?		accessible annotation autosomes bcor chromosome embryonic entire es establishing hemizygous http humans ibme lethal mutagenic mutational null phenotypes publicly retardation screen screens syntenic technologies trapped utoronto website xlinkedgenes xlmr	acta2 amscs architectural cd105 cd73 cd90 chondrogenic confluence confluent cyto eng fibroblastic hinfp nes npat nt5e pou5f1 renewing rnaseq sfrp2 sfrp4 successively thy1 versatility wisp2 wnt2 wnt2b wnt5a wnt7b
Tagcloud (Intersection) ?