APOC4 and MICOS10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		APOC4	MICOS10
Description		apolipoprotein C4	mitochondrial contact site and cristae organizing system subunit 10
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Very-low-density Lipoprotein Particle High-density Lipoprotein Particle	SAM Complex Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Crista Junction MICOS Complex MIB Complex
	Molecular Function	Lipid Transporter Activity Protein Binding	Protein Binding
	Biological Process	Lipid Metabolic Process Lipid Transport Lipid Storage Triglyceride Homeostasis	Inner Mitochondrial Membrane Organization Cristae Formation
Pathways		VLDL assembly VLDL clearance VLDL clearance NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Cristae formation
Drugs
Diseases
GWAS		Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) HDL cholesterol levels ( 32203549) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 20864672 19060906 18802019 18193044 18193043) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Quantitative traits ( 19197348) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		24 interacting genes: APOL2 BCL2L2 DIABLO GAD2 GSDMA IFI27 LETMD1 MAIP1 MICOS10 MICOS13 NFU1 PORCN RSAD2 SENP2 SNAP47 SYT16 TBC1D20 THBD TIMMDC1 TMEM14B TPRG1 UBQLN1 UBQLN2 VKORC1	4 interacting genes: APOC2 APOC4 CIDEB MPC2
Entrez ID		346	440574
HPRD ID		02848	18824
Ensembl ID		ENSG00000267467	ENSG00000173436
Uniprot IDs		P55056	A0A087WU07 Q5TGZ0
PDB IDs
Enriched GO Terms of Interacting Partners?		Virion Assembly Membrane Mitochondrion Mitochondrion Organization Mitochondrial Inner Membrane Inner Mitochondrial Membrane Organization MICOS Complex Mitochondrial Crista Junction SAM Complex MIB Complex Host-mediated Perturbation Of Viral Genome Replication Mitochondrial Membrane Cristae Formation Host-mediated Perturbation Of Viral Process Mitochondrial Outer Membrane Negative Regulation Of Platelet Activation Positive Regulation Of ERAD Pathway Mitochondrial Calcium Ion Homeostasis Host-mediated Perturbation Of Symbiont Process Mitochondrial Membrane Organization Modulation Of Process Of Another Organism Extrinsic Apoptotic Signaling Pathway Regulation Of ERAD Pathway Negative Regulation Of Phospholipid Efflux Lipoprotein Metabolic Process Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Host-mediated Activation Of Viral Process Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Positive Regulation Of Coagulation Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Store-operated Calcium Channel Activity Palmitoleoyltransferase Activity Protein Palmitoleylation Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Positive Regulation Of Response To Endoplasmic Reticulum Stress Pyroptotic Inflammatory Response 4 Iron, 4 Sulfur Cluster Binding Organelle Organization Negative Regulation Of Coagulation Negative Regulation Of Blood Coagulation Positive Regulation Of Presynaptic Membrane Organization Chylomicron Remnant Lipid Transport Involved In Lipid Storage Lipoprotein Particle Protein Binding Regulation Of Platelet Activation	Acylglycerol Homeostasis High-density Lipoprotein Particle Lipid Transport Very-low-density Lipoprotein Particle Triglyceride Homeostasis Regulation Of Triglyceride Metabolic Process Lipid Storage Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Pyruvate Import Into Mitochondria Lipid Homeostasis Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Chylomicron Remodeling Positive Regulation Of Phospholipid Catabolic Process Chylomicron Remnant Clearance Triglyceride-rich Lipoprotein Particle Clearance Intermediate-density Lipoprotein Particle Lipoprotein Lipase Activator Activity Pyruvate Transmembrane Transport Pyruvate Transmembrane Transporter Activity Inner Mitochondrial Membrane Protein Complex Lipid Droplet Fusion Spherical High-density Lipoprotein Particle Positive Regulation Of Triglyceride Catabolic Process Regulation Of Phospholipid Catabolic Process Lipase Inhibitor Activity Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Clearance Pyruvate Transport Import Into The Mitochondrion Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Lipid Metabolic Process Triglyceride-rich Lipoprotein Particle Remodeling Phospholipase Activator Activity Very-low-density Lipoprotein Particle Assembly Lipoprotein Catabolic Process Chylomicron Phospholipid Efflux Lipid Transfer Activity Acetyl-CoA Biosynthetic Process COPI-coated Vesicle Low-density Lipoprotein Particle COPII Vesicle Coat Reverse Cholesterol Transport Identical Protein Binding Negative Regulation Of Lipoprotein Particle Clearance COPII-coated Vesicle Cargo Loading Phospholipase Binding Negative Regulation Of Cholesterol Transport Mitochondrial Transmembrane Transport Positive Regulation Of Triglyceride Metabolic Process
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