APOC4 and IFI27

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		APOC4	IFI27
Description		apolipoprotein C4	interferon alpha inducible protein 27
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Very-low-density Lipoprotein Particle High-density Lipoprotein Particle	Nucleus Nuclear Envelope Nuclear Inner Membrane Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Mitochondrial Membrane
	Molecular Function	Lipid Transporter Activity Protein Binding	Protein Binding Lamin Binding Identical Protein Binding Molecular Adaptor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Lipid Metabolic Process Lipid Transport Lipid Storage Triglyceride Homeostasis	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Host-mediated Perturbation Of Viral Genome Replication Innate Immune Response Regulation Of Protein Export From Nucleus Defense Response To Virus Type I Interferon-mediated Signaling Pathway Pyroptotic Inflammatory Response Protein K48-linked Ubiquitination Extrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway
Pathways		VLDL assembly VLDL clearance VLDL clearance NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Interferon alpha/beta signaling Modulation of host responses by IFN-stimulated genes
Drugs
Diseases
GWAS		Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) HDL cholesterol levels ( 32203549) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 20864672 19060906 18802019 18193044 18193043) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Quantitative traits ( 19197348) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		24 interacting genes: APOL2 BCL2L2 DIABLO GAD2 GSDMA IFI27 LETMD1 MAIP1 MICOS10 MICOS13 NFU1 PORCN RSAD2 SENP2 SNAP47 SYT16 TBC1D20 THBD TIMMDC1 TMEM14B TPRG1 UBQLN1 UBQLN2 VKORC1	4 interacting genes: APOC2 APOC4 CCND1 CDK4
Entrez ID		346	3429
HPRD ID		02848	02479
Ensembl ID		ENSG00000267467	ENSG00000165949
Uniprot IDs		P55056	P40305
PDB IDs
Enriched GO Terms of Interacting Partners?		Virion Assembly Membrane Mitochondrion Mitochondrion Organization Mitochondrial Inner Membrane Inner Mitochondrial Membrane Organization MICOS Complex Mitochondrial Crista Junction SAM Complex MIB Complex Host-mediated Perturbation Of Viral Genome Replication Mitochondrial Membrane Cristae Formation Host-mediated Perturbation Of Viral Process Mitochondrial Outer Membrane Negative Regulation Of Platelet Activation Positive Regulation Of ERAD Pathway Mitochondrial Calcium Ion Homeostasis Host-mediated Perturbation Of Symbiont Process Mitochondrial Membrane Organization Modulation Of Process Of Another Organism Extrinsic Apoptotic Signaling Pathway Regulation Of ERAD Pathway Negative Regulation Of Phospholipid Efflux Lipoprotein Metabolic Process Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Host-mediated Activation Of Viral Process Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Positive Regulation Of Coagulation Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Store-operated Calcium Channel Activity Palmitoleoyltransferase Activity Protein Palmitoleylation Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Positive Regulation Of Response To Endoplasmic Reticulum Stress Pyroptotic Inflammatory Response 4 Iron, 4 Sulfur Cluster Binding Organelle Organization Negative Regulation Of Coagulation Negative Regulation Of Blood Coagulation Positive Regulation Of Presynaptic Membrane Organization Chylomicron Remnant Lipid Transport Involved In Lipid Storage Lipoprotein Particle Protein Binding Regulation Of Platelet Activation	Cyclin D1-CDK4 Complex High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Acylglycerol Homeostasis Triglyceride Homeostasis Cyclin-dependent Protein Kinase Holoenzyme Complex Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Kinase Activity Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Mitotic Cell Cycle Cyclin D1-CDK6 Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle Bicellular Tight Junction Cyclin D3-CDK4 Complex Futile Creatine Cycle Positive Regulation Of Phospholipid Catabolic Process Lipoprotein Lipase Activator Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cyclin D2-CDK4 Complex Lipid Homeostasis Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Chylomicron Remodeling Re-entry Into Mitotic Cell Cycle Chylomicron Remnant Clearance Triglyceride-rich Lipoprotein Particle Clearance Intermediate-density Lipoprotein Particle Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Response To Ketone Cellular Response To Ionomycin Phosphocreatine Biosynthetic Process Creatine Kinase Activity Spherical High-density Lipoprotein Particle Positive Regulation Of Triglyceride Catabolic Process Regulation Of Phospholipid Catabolic Process Lipase Inhibitor Activity Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Clearance Positive Regulation Of Cell Cycle Process Response To Vitamin E Nuclear Membrane Response To Alcohol Triglyceride-rich Lipoprotein Particle Remodeling
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