APOC4 and APOL2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		APOC4	APOL2
Description		apolipoprotein C4	apolipoprotein L2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Very-low-density Lipoprotein Particle High-density Lipoprotein Particle	Extracellular Region Cytoplasm Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Lipid Transporter Activity Protein Binding	Signaling Receptor Binding Protein Binding High-density Lipoprotein Particle Binding Lipid Binding
	Biological Process	Lipid Metabolic Process Lipid Transport Lipid Storage Triglyceride Homeostasis	Lipid Metabolic Process Lipid Transport Acute-phase Response Cholesterol Metabolic Process Lipoprotein Metabolic Process Maternal Process Involved In Female Pregnancy
Pathways		VLDL assembly VLDL clearance VLDL clearance NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases
GWAS		Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) HDL cholesterol levels ( 32203549) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 20864672 19060906 18802019 18193044 18193043) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Quantitative traits ( 19197348) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Epigenetic age acceleration in alcohol use disorder ( 31466081)
Interacting Genes		24 interacting genes: APOL2 BCL2L2 DIABLO GAD2 GSDMA IFI27 LETMD1 MAIP1 MICOS10 MICOS13 NFU1 PORCN RSAD2 SENP2 SNAP47 SYT16 TBC1D20 THBD TIMMDC1 TMEM14B TPRG1 UBQLN1 UBQLN2 VKORC1	38 interacting genes: AIG1 APOC2 APOC4 AR BSND CISD2 CYBC1 EBAG9 ELOVL4 EMP1 ERGIC3 FAM209A FAM210B GET1 GJB5 ITGB2 KCNA1 LMNA MARCHF3 MFF MGST3 PANX1 PSCA SFXN5 SIT1 SLC18A1 SLC26A6 SLC35H1 STX1A STX2 TIMMDC1 TMED8 TMEM139 TMEM45B TMEM52B TMEM60 USE1 YIPF6
Entrez ID		346	23780
HPRD ID		02848	06263
Ensembl ID		ENSG00000267467	ENSG00000128335
Uniprot IDs		P55056	Q9BQE5
PDB IDs			7LF8
Enriched GO Terms of Interacting Partners?		Virion Assembly Membrane Mitochondrion Mitochondrion Organization Mitochondrial Inner Membrane Inner Mitochondrial Membrane Organization MICOS Complex Mitochondrial Crista Junction SAM Complex MIB Complex Host-mediated Perturbation Of Viral Genome Replication Mitochondrial Membrane Cristae Formation Host-mediated Perturbation Of Viral Process Mitochondrial Outer Membrane Negative Regulation Of Platelet Activation Positive Regulation Of ERAD Pathway Mitochondrial Calcium Ion Homeostasis Host-mediated Perturbation Of Symbiont Process Mitochondrial Membrane Organization Modulation Of Process Of Another Organism Extrinsic Apoptotic Signaling Pathway Regulation Of ERAD Pathway Negative Regulation Of Phospholipid Efflux Lipoprotein Metabolic Process Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Host-mediated Activation Of Viral Process Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Positive Regulation Of Coagulation Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Store-operated Calcium Channel Activity Palmitoleoyltransferase Activity Protein Palmitoleylation Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Positive Regulation Of Response To Endoplasmic Reticulum Stress Pyroptotic Inflammatory Response 4 Iron, 4 Sulfur Cluster Binding Organelle Organization Negative Regulation Of Coagulation Negative Regulation Of Blood Coagulation Positive Regulation Of Presynaptic Membrane Organization Chylomicron Remnant Lipid Transport Involved In Lipid Storage Lipoprotein Particle Protein Binding Regulation Of Platelet Activation	Membrane SNAP Receptor Activity Endoplasmic Reticulum SNARE Complex
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