FZD9 and WNT1

Number of citations of the paper that reports this interaction (PMID 9147651)
15

Data Source:
HPRD (in vivo)

		FZD9	WNT1
Gene Name		frizzled class receptor 9	wingless-type MMTV integration site family, member 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Surface Integral Component Of Membrane Filopodium Membrane Perinuclear Region Of Cytoplasm	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface
	Molecular Function	G-protein Coupled Receptor Activity Wnt-protein Binding Protein Homodimerization Activity Wnt-activated Receptor Activity Protein Heterodimerization Activity	Frizzled Binding Cytokine Activity Protein Domain Specific Binding Transcription Regulatory Region DNA Binding Receptor Agonist Activity
	Biological Process	G-protein Coupled Receptor Signaling Pathway Nervous System Development Neuroblast Proliferation Learning Or Memory B Cell Differentiation Non-canonical Wnt Signaling Pathway Canonical Wnt Signaling Pathway	Embryonic Axis Specification Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Protein Phosphorylation Cell-cell Signaling Myoblast Fusion Positive Regulation Of Cell Proliferation Response To Wounding Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Cell-substrate Adhesion Wnt Signaling Pathway Spinal Cord Association Neuron Differentiation Diencephalon Development Central Nervous System Morphogenesis Cerebellum Formation Forebrain Anterior/posterior Pattern Specification Midbrain-hindbrain Boundary Maturation During Brain Development Negative Regulation Of Cell-cell Adhesion Neuron Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Midbrain Development Organ Regeneration T Cell Differentiation In Thymus Inner Ear Morphogenesis Signal Transduction In Response To DNA Damage Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Cell Fate Commitment Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation Neuron Fate Determination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Spemann Organizer Formation Canonical Wnt Signaling Pathway Bone Development Positive Regulation Of Dermatome Development Hepatocyte Differentiation Cellular Response To Peptide Hormone Stimulus Hematopoietic Stem Cell Proliferation Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cell Aging Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes WNT ligand biogenesis and trafficking beta-catenin independent WNT signaling disassembly of the destruction complex and recruitment of AXIN to the membrane WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Transcriptional regulation of white adipocyte differentiation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Class B/2 (Secretin family receptors) PCP/CE pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: KRTAP10-3 MDFI SIAH1 WNT1 WNT2 WNT7A	9 interactors: FZD8 FZD9 LRP5 LRP6 PORCN RYK SFRP1 SFRP2 WNT3A
Entrez ID		8326	7471
HPRD ID		03460	01276
Ensembl ID		ENSG00000188763
Uniprot IDs		O00144	P04628
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Receptor Activity Regulation Of Wnt Signaling Pathway Positive Regulation Of Signal Transduction Canonical Wnt Signaling Pathway Axis Specification Regulation Of Receptor Activity Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Anatomical Structure Morphogenesis Wnt Signaling Pathway Organ Morphogenesis Positive Regulation Of Embryonic Development Cell Fate Commitment Regulation Of Signal Transduction Neuron Differentiation Embryo Development Single Organism Reproductive Process Regulation Of Signaling Cerebellum Morphogenesis Developmental Induction Reproductive Process Embryonic Axis Specification Hindbrain Morphogenesis Cell Differentiation Positive Regulation Of Fibroblast Proliferation Pattern Specification Process Embryonic Organ Development Reproductive Structure Development Generation Of Neurons Reproductive System Development Neurogenesis Skeletal System Development Embryonic Pattern Specification Sensory Organ Development Lens Development In Camera-type Eye Regulation Of Fibroblast Proliferation Regulation Of Transcription From RNA Polymerase II Promoter System Development Embryonic Morphogenesis Tissue Morphogenesis Midbrain-hindbrain Boundary Maturation During Brain Development Cerebellum Formation Wnt Signaling Pathway Involved In Wound Healing, Spreading Of Epidermal Cells Embryonic Placenta Development Cerebellum Development Regulation Of Embryonic Development Dorsal/ventral Pattern Formation Positive Regulation Of JNK Cascade Tube Development	Wnt Signaling Pathway Canonical Wnt Signaling Pathway Axis Elongation Involved In Somitogenesis Non-canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Axis Elongation Regulation Of Fat Cell Differentiation Wnt Signaling Pathway Involved In Somitogenesis Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Cell Surface Receptor Signaling Pathway Convergent Extension Anterior/posterior Pattern Specification Somitogenesis Stem Cell Proliferation Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Somite Development Regulation Of Wnt Signaling Pathway Positive Regulation Of Signal Transduction Post-anal Tail Morphogenesis Regulation Of Phosphorylation Immune System Development Regulation Of Embryonic Development Segmentation Regulation Of Protein Kinase Activity Dorsal/ventral Axis Specification Dorsal/ventral Pattern Formation Regulation Of Kinase Activity Wnt Signaling Pathway Involved In Forebrain Neuroblast Division Regulation Of Phosphorus Metabolic Process Epithelial Tube Morphogenesis Negative Regulation Of Protein Serine/threonine Kinase Activity Developmental Growth Involved In Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Stem Cell Differentiation Tube Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Axis Elongation Pattern Specification Process Regulation Of Organ Morphogenesis Regulation Of Bone Remodeling Morphogenesis Of An Epithelium Negative Regulation Of Wnt Signaling Pathway Neural Tube Development Organ Development Anatomical Structure Formation Involved In Morphogenesis Regulation Of Ossification Regulation Of Protein Phosphorylation Mesenchyme Development Neural Crest Formation
Tagcloud ?		ascl2 c4b dab2ip dlk1 eya4 fabp3 gas7 hdac9 hoxa11 hoxa5 hoxa9 hoxb13 ihh ipf1 isl1 mest mme pax6 ptgs2 rassf1 rbp1 scgb3a1 sept5 serpina5 sox1 sox17 tbx1 tff1 thy1	access acid breaks chromosome cloning embryonic experiments inducible karyotypes late lines morphologies morphology neurogenesis observing p19 placed produced responsive resulting retinoic see sequences transcribed undifferentiated useful variety wide would
Tagcloud (Difference) ?		ascl2 c4b dab2ip dlk1 eya4 fabp3 gas7 hdac9 hoxa11 hoxa5 hoxa9 hoxb13 ihh ipf1 isl1 mest mme pax6 ptgs2 rassf1 rbp1 scgb3a1 sept5 serpina5 sox1 sox17 tbx1 tff1 thy1	access acid breaks chromosome cloning embryonic experiments inducible karyotypes late lines morphologies morphology neurogenesis observing p19 placed produced responsive resulting retinoic see sequences transcribed undifferentiated useful variety wide would
Tagcloud (Intersection) ?