FZD9 and WNT1

Number of citations of the paper that reports this interaction (PubMedID 9147651)
0

Data Source:
HPRD (in vivo)

		FZD9	WNT1
Description		frizzled class receptor 9	Wnt family member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Cell Surface Membrane Filopodium Membrane Mitochondrial Membrane Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Endocytic Vesicle Membrane Extracellular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Wnt-protein Binding Protein Homodimerization Activity Wnt Receptor Activity Protein Heterodimerization Activity	Signaling Receptor Binding Frizzled Binding Cytokine Activity Morphogen Activity Protein Domain Specific Binding Receptor Ligand Activity
	Biological Process	Ossification Release Of Cytochrome C From Mitochondria Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Nervous System Development Neuroblast Proliferation Learning Or Memory Wnt Signaling Pathway B Cell Differentiation Positive Regulation Of Bone Mineralization Non-canonical Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Cell Cycle Negative Regulation Of Mitochondrial Depolarization Canonical Wnt Signaling Pathway Negative Regulation Of Necroptotic Process Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Negative Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Bone Regeneration Positive Regulation Of Neural Precursor Cell Proliferation	Embryonic Axis Specification Branching Involved In Ureteric Bud Morphogenesis Cell-cell Signaling Myoblast Fusion Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Response To Wounding Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Cell-substrate Adhesion Myotube Differentiation Wnt Signaling Pathway Spinal Cord Association Neuron Differentiation Diencephalon Development Cerebellum Development Central Nervous System Morphogenesis Cerebellum Formation Forebrain Anterior/posterior Pattern Specification Midbrain-hindbrain Boundary Maturation During Brain Development Neurogenesis Metencephalon Development Negative Regulation Of Cell-cell Adhesion Neuron Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Midbrain Development Midbrain-hindbrain Boundary Development Animal Organ Regeneration T Cell Differentiation In Thymus Cell Proliferation In Midbrain Astrocyte-dopaminergic Neuron Signaling Inner Ear Morphogenesis Signal Transduction In Response To DNA Damage Negative Regulation Of Apoptotic Process Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cell Fate Commitment Fat Cell Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Neuron Fate Commitment Neuron Fate Determination Spemann Organizer Formation Canonical Wnt Signaling Pathway Bone Development Positive Regulation Of Dermatome Development Hepatocyte Differentiation Cellular Response To Peptide Hormone Stimulus Hematopoietic Stem Cell Proliferation Dopaminergic Neuron Differentiation Positive Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Midbrain Dopaminergic Neuron Differentiation Embryonic Brain Development Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Senescence
Pathways		Class B/2 (Secretin family receptors)	TCF dependent signaling in response to WNT TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors) Transcriptional regulation of white adipocyte differentiation PCP/CE pathway PCP/CE pathway Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane
Drugs
Diseases
GWAS		HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Lamb consumption ( 32066663) Malaria ( 31844061) Meat-related diet ( 32066663) Non-oily fish consumption ( 32066663) Protein C levels ( 28082259)	Bipolar disorder ( 31043756) Heel bone mineral density ( 28869591 30598549)
Interacting Genes		6 interacting genes: KRTAP10-3 MDFI SIAH1 WNT1 WNT2 WNT7A	9 interacting genes: FZD8 FZD9 LRP5 LRP6 PORCN RYK SFRP1 SFRP2 WNT3A
Entrez ID		8326	7471
HPRD ID		03460	01276
Ensembl ID		ENSG00000188763	ENSG00000125084
Uniprot IDs		O00144	P04628
PDB IDs
Enriched GO Terms of Interacting Partners?		Canonical Wnt Signaling Pathway Frizzled Binding Wnt Signaling Pathway Cell Proliferation In Midbrain Axis Specification Neural Precursor Cell Proliferation Midbrain Dopaminergic Neuron Differentiation Receptor Ligand Activity Central Nervous System Neuron Differentiation Cell Fate Commitment Anatomical Structure Morphogenesis Cytokine Activity Embryonic Axis Specification Dopaminergic Neuron Differentiation Positive Regulation Of Fibroblast Proliferation Neuron Differentiation Embryonic Pattern Specification Cellular Response To Transforming Growth Factor Beta Stimulus Pattern Specification Process Cell Differentiation Signaling Receptor Binding Response To Transforming Growth Factor Beta Embryonic Morphogenesis Endocytic Vesicle Membrane Midbrain-hindbrain Boundary Maturation During Brain Development Cerebellum Formation Regulation Of Embryonic Development Asymmetric Protein Localization Involved In Cell Fate Determination Regulation Of Fibroblast Proliferation Golgi Lumen Cellular Developmental Process Central Nervous System Morphogenesis Neurogenesis Diencephalon Development Positive Regulation Of Protein Localization To Presynapse Postsynapse Assembly Positive Regulation Of Excitatory Synapse Assembly Positive Regulation Of Dermatome Development Astrocyte-dopaminergic Neuron Signaling Metencephalon Development Lung Induction Oviduct Development Regulation Of JNK Cascade Embryonic Organ Development Forebrain Anterior/posterior Pattern Specification Spemann Organizer Formation Glial Cell-neuron Signaling Midbrain-hindbrain Boundary Development Cell Population Proliferation Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration	Wnt-protein Binding Canonical Wnt Signaling Pathway Wnt Signaling Pathway Wnt-Frizzled-LRP5/6 Complex Wnt Receptor Activity Non-canonical Wnt Signaling Pathway Frizzled Binding Dopaminergic Neuron Differentiation Regulation Of Dopaminergic Neuron Differentiation Cell Surface Receptor Signaling Pathway Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Neuron Differentiation Regulation Of Fat Cell Differentiation Wnt Signaling Pathway Involved In Somitogenesis Regulation Of Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Wnt Signaling Pathway Anterior/posterior Pattern Specification Negative Regulation Of Cell Growth Somitogenesis Development Of Primary Male Sexual Characteristics Positive Regulation Of Neural Precursor Cell Proliferation Segmentation Positive Regulation Of Cell Population Proliferation Coreceptor Activity Convergent Extension Involved In Axis Elongation Negative Regulation Of Growth Toxin Transmembrane Transporter Activity Regulation Of Establishment Of Planar Polarity Positive Regulation Of Fat Cell Differentiation Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Axon Extension Involved In Axon Guidance Development Of Primary Sexual Characteristics Regulation Of Mesodermal Cell Differentiation Regionalization Regulation Of Animal Organ Morphogenesis Cellular Response To X-ray Tube Morphogenesis Regulation Of Neural Precursor Cell Proliferation Cellular Developmental Process Negative Regulation Of Cell Differentiation Wnt Signalosome Regulation Of Wnt Signaling Pathway Convergent Extension Morphogenesis Of An Epithelium Tissue Development Signal Transduction Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Locomotion Anatomical Structure Formation Involved In Morphogenesis
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