FZD9 and WNT2

Number of citations: 0 (PubMedID 12138115)
Data Source: HPRD (in vivo)

		FZD9	WNT2
Name		frizzled class receptor 9	Wnt family member 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Cell Surface Membrane Filopodium Membrane Mitochondrial Membrane Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space Cytoplasm Extracellular Matrix Wnt Signalosome
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Wnt-protein Binding Protein Homodimerization Activity Wnt Receptor Activity Protein Heterodimerization Activity	Signaling Receptor Binding Frizzled Binding Cytokine Activity Protein Binding Receptor Ligand Activity
	Biological Process	Ossification Release Of Cytochrome C From Mitochondria Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Nervous System Development Neuroblast Proliferation Learning Or Memory Wnt Signaling Pathway B Cell Differentiation Positive Regulation Of Bone Mineralization Non-canonical Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Cell Cycle Negative Regulation Of Mitochondrial Depolarization Canonical Wnt Signaling Pathway Negative Regulation Of Necroptotic Process Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Negative Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Bone Regeneration Positive Regulation Of Neural Precursor Cell Proliferation	Positive Regulation Of Mesenchymal Cell Proliferation Lens Development In Camera-type Eye Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Mesenchymal Cell Proliferation Wnt Signaling Pathway Neurogenesis Neuron Differentiation Cell Proliferation In Midbrain Cell Fate Commitment Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Animal Organ Development System Development Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Neurogenesis Atrial Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Cardiac Epithelial To Mesenchymal Transition Lung Induction Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Epithelial Cell Proliferation Involved In Lung Morphogenesis Labyrinthine Layer Blood Vessel Development Iris Morphogenesis Mammary Gland Epithelium Development Cellular Response To Retinoic Acid Cellular Response To Transforming Growth Factor Beta Stimulus Midbrain Dopaminergic Neuron Differentiation
Pathways		Class B/2 (Secretin family receptors)	WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)
GWAS		HDL cholesterol levels ( 32203549 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Lamb consumption ( 32066663 ) Malaria ( 31844061 ) Meat-related diet ( 32066663 ) Non-oily fish consumption ( 32066663 ) Protein C levels ( 28082259 )	Dupuytren's disease ( 21732829 28886342 ) Inflammatory bowel disease ( 28067908 ) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573 ) Tonsillectomy ( 27182965 28928442 ) Ulcerative colitis ( 28067908 ) Uterine fibroids ( 31649266 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		6 interacting genes: KRTAP10-3 MDFI SIAH1 WNT1 WNT2 WNT7A	8 interacting genes: AQP5 FZD1 FZD9 HCK RRAGC SFRP1 UQCR11 WNT3A
Entrez ID		8326	7472
HPRD ID		03460	00999
Ensembl ID		ENSG00000188763	ENSG00000105989
Uniprot IDs		O00144	A0A384MDX3 P09544
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Canonical Wnt Signaling Pathway Frizzled Binding Wnt Signaling Pathway Cell Proliferation In Midbrain Axis Specification Neural Precursor Cell Proliferation Midbrain Dopaminergic Neuron Differentiation Receptor Ligand Activity Central Nervous System Neuron Differentiation Cell Fate Commitment Anatomical Structure Morphogenesis Cytokine Activity Embryonic Axis Specification Dopaminergic Neuron Differentiation Positive Regulation Of Fibroblast Proliferation Neuron Differentiation Embryonic Pattern Specification Cellular Response To Transforming Growth Factor Beta Stimulus Pattern Specification Process Cell Differentiation Signaling Receptor Binding Response To Transforming Growth Factor Beta Embryonic Morphogenesis Endocytic Vesicle Membrane Midbrain-hindbrain Boundary Maturation During Brain Development Cerebellum Formation Regulation Of Embryonic Development Asymmetric Protein Localization Involved In Cell Fate Determination Regulation Of Fibroblast Proliferation Golgi Lumen Cellular Developmental Process Central Nervous System Morphogenesis Neurogenesis Diencephalon Development Positive Regulation Of Protein Localization To Presynapse Postsynapse Assembly Positive Regulation Of Excitatory Synapse Assembly Positive Regulation Of Dermatome Development Astrocyte-dopaminergic Neuron Signaling Metencephalon Development Lung Induction Oviduct Development Regulation Of JNK Cascade Embryonic Organ Development Forebrain Anterior/posterior Pattern Specification Spemann Organizer Formation Glial Cell-neuron Signaling Midbrain-hindbrain Boundary Development Cell Population Proliferation Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration	Non-canonical Wnt Signaling Pathway Canonical Wnt Signaling Pathway Wnt-protein Binding Dopaminergic Neuron Differentiation Frizzled Binding Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Regulation Of Dopaminergic Neuron Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Midbrain Dopaminergic Neuron Differentiation Presynapse Assembly Wnt Receptor Activity Positive Regulation Of Wnt Signaling Pathway Presynapse Organization Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Cell Surface Regulation Of Cell Junction Assembly Somitogenesis Segmentation Positive Regulation Of Neural Precursor Cell Proliferation Mesoderm Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Negative Regulation Of BMP Signaling Pathway Convergent Extension Involved In Somitogenesis Neuron Differentiation Negative Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Wnt Signaling Pathway Involved In Forebrain Neuroblast Division Calcium Ion Transmembrane Transport Via Low Voltage-gated Calcium Channel Positive Regulation Of Mesodermal Cell Fate Specification Regulation Of Animal Organ Morphogenesis Regulation Of Apoptotic Signaling Pathway Signaling Receptor Binding Tissue Morphogenesis Cell Surface Receptor Signaling Pathway Regulation Of Neuron Projection Development Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Receptor Clustering Neural Precursor Cell Proliferation Axis Elongation Involved In Somitogenesis Positive Regulation Of Cell Fate Specification Regulation Of Postsynapse To Nucleus Signaling Pathway Paraxial Mesodermal Cell Fate Commitment Positive Regulation Of Collateral Sprouting In Absence Of Injury Cellular Response To Lipid Positive Regulation Of Cellular Component Organization Regulation Of BMP Signaling Pathway