FZD9 and WNT7A

Number of citations of the paper that reports this interaction (PubMedID 15705594)
0

Data Source:
HPRD (in vivo)

		FZD9	WNT7A
Description		frizzled class receptor 9	Wnt family member 7A
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Cell Surface Membrane Filopodium Membrane Mitochondrial Membrane Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Endocytic Vesicle Membrane Extracellular Matrix Extracellular Exosome Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Wnt-protein Binding Protein Homodimerization Activity Wnt Receptor Activity Protein Heterodimerization Activity	Signaling Receptor Binding Frizzled Binding Cytokine Activity Protein Binding Receptor Ligand Activity
	Biological Process	Ossification Release Of Cytochrome C From Mitochondria Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Nervous System Development Neuroblast Proliferation Learning Or Memory Wnt Signaling Pathway B Cell Differentiation Positive Regulation Of Bone Mineralization Non-canonical Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Cell Cycle Negative Regulation Of Mitochondrial Depolarization Canonical Wnt Signaling Pathway Negative Regulation Of Necroptotic Process Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Negative Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Bone Regeneration Positive Regulation Of Neural Precursor Cell Proliferation	Embryonic Axis Specification Cartilage Condensation Angiogenesis Chondrocyte Differentiation Apoptotic Process Neurotransmitter Secretion Axonogenesis Synapse Assembly Sex Differentiation Positive Regulation Of Cell Population Proliferation Tissue Development Dorsal/ventral Pattern Formation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Skeletal Muscle Satellite Cell Activation Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Wnt Signaling Pathway Cerebellar Granule Cell Differentiation Cell Proliferation In Forebrain Central Nervous System Vasculogenesis Establishment Of Cell Polarity Cell Differentiation Neuron Differentiation Embryonic Limb Morphogenesis Regulation Of Axon Diameter Response To Estradiol Somatic Stem Cell Population Maintenance Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Wound Healing, Spreading Of Epidermal Cells Non-canonical Wnt Signaling Pathway Synaptic Vesicle Recycling Regulation Of Cell Population Proliferation Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Response To Estrogen Cell Fate Commitment Asymmetric Protein Localization Involved In Cell Fate Determination Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Somatic Stem Cell Division Animal Organ Development System Development Stem Cell Development Regulation Of Epithelial Cell Proliferation Negative Regulation Of Neurogenesis Regulation Of Axonogenesis Synapse Organization Cartilage Development Positive Regulation Of Protein Metabolic Process Positive Regulation Of Synapse Assembly Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Uterus Development Oviduct Development Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Limb Development Establishment Of Blood-brain Barrier Dendritic Spine Morphogenesis Uterus Morphogenesis Secondary Palate Development Lens Fiber Cell Development Cellular Response To Transforming Growth Factor Beta Stimulus Presynapse Assembly Postsynapse Assembly Regulation Of Postsynapse Organization Excitatory Synapse Assembly Positive Regulation Of Excitatory Synapse Assembly Positive Regulation Of Protein Localization To Presynapse Regulation Of Presynapse Assembly Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Class B/2 (Secretin family receptors)	WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)
Drugs
Diseases			Al-Awadi/Raas-Rothschild syndrome; Ulna and fibula, absence of, with sever limb deficiency Fuhrmann syndrome; Fibular aplasia or hypoplasia, femoral bowing and poly-, syn-, and oligodactyly
GWAS		HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Lamb consumption ( 32066663) Malaria ( 31844061) Meat-related diet ( 32066663) Non-oily fish consumption ( 32066663) Protein C levels ( 28082259)	Body mass index ( 26426971) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Creatinine levels ( 29124443) Estimated glomerular filtration rate ( 29124443 31152163) Glomerular filtration rate (creatinine) ( 26831199) Hematocrit ( 32888494) Pulse pressure ( 27841878 30578418) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Serum uric acid levels ( 29124443)
Interacting Genes		6 interacting genes: KRTAP10-3 MDFI SIAH1 WNT1 WNT2 WNT7A	3 interacting genes: FZD5 FZD9 STRN4
Entrez ID		8326	7476
HPRD ID		03460	03341
Ensembl ID		ENSG00000188763	ENSG00000154764
Uniprot IDs		O00144	O00755
PDB IDs			4UZQ 8TZO 8TZP
Enriched GO Terms of Interacting Partners?		Canonical Wnt Signaling Pathway Frizzled Binding Wnt Signaling Pathway Cell Proliferation In Midbrain Axis Specification Neural Precursor Cell Proliferation Midbrain Dopaminergic Neuron Differentiation Receptor Ligand Activity Central Nervous System Neuron Differentiation Cell Fate Commitment Anatomical Structure Morphogenesis Cytokine Activity Embryonic Axis Specification Dopaminergic Neuron Differentiation Positive Regulation Of Fibroblast Proliferation Neuron Differentiation Embryonic Pattern Specification Cellular Response To Transforming Growth Factor Beta Stimulus Pattern Specification Process Cell Differentiation Signaling Receptor Binding Response To Transforming Growth Factor Beta Embryonic Morphogenesis Endocytic Vesicle Membrane Midbrain-hindbrain Boundary Maturation During Brain Development Cerebellum Formation Regulation Of Embryonic Development Asymmetric Protein Localization Involved In Cell Fate Determination Regulation Of Fibroblast Proliferation Golgi Lumen Cellular Developmental Process Central Nervous System Morphogenesis Neurogenesis Diencephalon Development Positive Regulation Of Protein Localization To Presynapse Postsynapse Assembly Positive Regulation Of Excitatory Synapse Assembly Positive Regulation Of Dermatome Development Astrocyte-dopaminergic Neuron Signaling Metencephalon Development Lung Induction Oviduct Development Regulation Of JNK Cascade Embryonic Organ Development Forebrain Anterior/posterior Pattern Specification Spemann Organizer Formation Glial Cell-neuron Signaling Midbrain-hindbrain Boundary Development Cell Population Proliferation Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration	Wnt Receptor Activity Wnt-protein Binding Non-canonical Wnt Signaling Pathway Canonical Wnt Signaling Pathway Negative Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Wnt Signaling Pathway Transmembrane Signaling Receptor Activity Intestinal Epithelial Cell Maturation Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Spemann Organizer Formation Post-embryonic Camera-type Eye Development Lymphocyte Differentiation Negative Regulation Of Receptor Clustering Bone Regeneration Regulation Of Chorionic Trophoblast Cell Proliferation Chorionic Trophoblast Cell Differentiation Leukocyte Differentiation Glandular Epithelial Cell Maturation Anterior/posterior Axis Specification, Embryo G Protein-coupled Receptor Activity Protein-containing Complex Binding Mononuclear Cell Differentiation Branching Involved In Labyrinthine Layer Morphogenesis Columnar/cuboidal Epithelial Cell Maturation Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Negative Regulation Of Mitochondrial Depolarization Armadillo Repeat Domain Binding Dendrite Lymphocyte Activation Embryonic Camera-type Eye Development Embryonic Camera-type Eye Morphogenesis Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Modification Of Postsynaptic Structure Regulation Of Bicellular Tight Junction Assembly Regulation Of Cellular Component Organization Leukocyte Activation Labyrinthine Layer Blood Vessel Development Cell Activation Cell Surface Apoptotic Process Involved In Morphogenesis Epithelial Cell Maturation Cell Differentiation Involved In Embryonic Placenta Development Negative Regulation Of Mitochondrial Membrane Permeability Release Of Cytochrome C From Mitochondria Negative Regulation Of Necroptotic Process Negative Regulation Of Programmed Necrotic Cell Death Regulation Of Mitochondrial Depolarization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Receptor Clustering Negative Regulation Of Membrane Permeability
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