GRM5 and RGS12

Number of citations of the paper that reports this interaction (PubMedID 9651375)
0

Data Source:
HPRD (in vitro)

		GRM5	RGS12
Description		glutamate metabotropic receptor 5	regulator of G protein signaling 12
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Dendrite Neuron Projection Neuronal Cell Body Dendritic Spine Dendritic Shaft Postsynaptic Membrane Astrocyte Projection Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Condensed Nuclear Chromosome Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Nuclear Matrix Dendrite Cell Projection Synapse
	Molecular Function	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity G Protein-coupled Receptor Activity Protein Binding Glutamate Receptor Activity Protein Tyrosine Kinase Activator Activity A2A Adenosine Receptor Binding Identical Protein Binding G Protein-coupled Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Protein Tyrosine Kinase Binding	GTPase Activity GTPase Activator Activity Protein Binding GTPase Regulator Activity
	Biological Process	Desensitization Of G Protein-coupled Receptor Signaling Pathway Regulation Of DNA-templated Transcription Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Learning Or Memory Learning Locomotory Behavior Positive Regulation Of MAPK Cascade Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Synapse Organization Positive Regulation Of Calcium-mediated Signaling Cognition Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Positive Regulation Of Intracellular Signal Transduction Cellular Response To Amyloid-beta	Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction
Pathways		G alpha (q) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) Neurexins and neuroligins Neurexins and neuroligins	G alpha (i) signalling events G alpha (i) signalling events
Drugs		Acamprosate ADX10059 Rufinamide Dipraglurant
Diseases
GWAS		Attention deficit hyperactivity disorder ( 22012869) Blond vs. brown/black hair color ( 30531825) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Depression ( 33859377) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) Hair color ( 30664655) Hypertension ( 31879980) Neurociticism ( 29500382) Nonsyndromic cleft lip ( 31609978) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Retinal detachment ( 31816047) Retinal detachment or retinal break ( 31816047) Rheumatoid arthritis (ACPA-negative) ( 24532677) Skin pigmentation ( 30664655 31315583) Skin pigmentation (conditioned on rs1426654 and rs35397) ( 31315583) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655) Tanning ( 19340012)	Adult body size ( 32376654) Coronary artery disease ( 29212778) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766 31015462) Glomerular filtration rate ( 29403010) Hepatocyte growth factor levels ( 25998175) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Platelet count ( 29403010) Serum albumin levels ( 29403010) Total cholesterol levels ( 29403010 33339817) Tuberculosis ( 29036319) Worry too long after an embarrassing experience ( 29500382)
Interacting Genes		20 interacting genes: ACTN1 CALM1 CALM2 CALM3 CAMK2A EFNB2 FLNA GPRASP1 HOMER1 HOMER3 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCQ PRKCZ RGS12 SIAH1 TAMALIN	17 interacting genes: ARAF CACNA1B CXCR2 EEF1A1 GNAI1 GNAI2 GNAI3 GRM2 GRM5 HRAS MAP2K2 MTNR1A NPY2R PLCB1 PLCB3 PM20D2 YWHAG
Entrez ID		2915	6002
HPRD ID		04980	03943
Ensembl ID		ENSG00000168959	ENSG00000159788
Uniprot IDs		A8K5P7 P41594	O14924
PDB IDs		3LMK 4OO9 5CGC 5CGD 6N4X 6N4Y 6N50 6N51 6N52 7FD8 7FD9 8T6J 8T7H 8T8M 8TAO 8X0B 8X0C 8X0D 8X0E 8X0F 8X0G 8X0H	2EBZ 2KV8
Enriched GO Terms of Interacting Partners?		Diacylglycerol-dependent Serine/threonine Kinase Activity Calyx Of Held Long-term Synaptic Potentiation Modulation Of Chemical Synaptic Transmission Regulation Of Transport Presynaptic Cytosol Positive Regulation Of Synaptic Transmission Regulation Of Cell Communication Regulation Of Signaling Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Signal Transduction Regulation Of Signal Transduction Regulation Of Metal Ion Transport Protein Serine Kinase Activity Regulation Of Calcium Ion Transport G Protein-coupled Receptor Signaling Pathway Protein Kinase C Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Serine/threonine Kinase Activity Transmembrane Transporter Binding Regulation Of Monoatomic Ion Transport Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Protein Kinase Activity Regulation Of Biological Quality Plasma Membrane Regulation Of Synaptic Plasticity Negative Regulation Of Transmembrane Transport Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Kinase Activity Calcium Channel Regulator Activity Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Regulation Of Sequestering Of Calcium Ion Titin Binding Regulation Of Platelet Activation Cytoplasm Sarcomere Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Histone H3T6 Kinase Activity Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Monoatomic Ion Transmembrane Transport	Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Negative Regulation Of Adenylate Cyclase Activity Guanyl Nucleotide Binding Signal Transduction G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission GTPase Activity Regulation Of Secretion By Cell Negative Regulation Of Catalytic Activity Glutamate Receptor Signaling Pathway Regulation Of Secretion GTP Binding Phosphatidylinositol Phospholipase C Activity G Protein-coupled Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Biological Quality G Protein-coupled Receptor Binding Regulation Of Synaptic Transmission, Glutamatergic Membrane GDP Binding Glutamate Receptor Activity Astrocyte Projection Phospholipase C Activity Regulation Of Cell Communication Regulation Of Signaling Calcium Ion Transmembrane Import Into Cytosol Nucleotide Binding G Protein-coupled Glutamate Receptor Signaling Pathway Intracellular Signal Transduction Schwann Cell Development Regulation Of Catalytic Activity Glutamatergic Synapse G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Ciliary Basal Body Cell-cell Signaling Regulation Of Dopamine Secretion Phosphatidylinositol-mediated Signaling Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Signaling Cell Surface Receptor Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Synaptic Signaling
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