GRM5

Description		glutamate metabotropic receptor 5
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Dendrite Neuron Projection Neuronal Cell Body Dendritic Spine Dendritic Shaft Postsynaptic Membrane Astrocyte Projection Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity G Protein-coupled Receptor Activity Protein Binding Glutamate Receptor Activity Protein Tyrosine Kinase Activator Activity A2A Adenosine Receptor Binding Identical Protein Binding G Protein-coupled Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Protein Tyrosine Kinase Binding
	Biological Process	Desensitization Of G Protein-coupled Receptor Signaling Pathway Regulation Of DNA-templated Transcription Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Learning Or Memory Learning Locomotory Behavior Positive Regulation Of MAPK Cascade Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Synapse Organization Positive Regulation Of Calcium-mediated Signaling Cognition Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Positive Regulation Of Intracellular Signal Transduction Cellular Response To Amyloid-beta
Pathways		G alpha (q) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) Neurexins and neuroligins Neurexins and neuroligins
Drugs		Acamprosate ADX10059 Rufinamide Dipraglurant
Diseases
GWAS		Attention deficit hyperactivity disorder ( 22012869) Blond vs. brown/black hair color ( 30531825) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Depression ( 33859377) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) Hair color ( 30664655) Hypertension ( 31879980) Neurociticism ( 29500382) Nonsyndromic cleft lip ( 31609978) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Retinal detachment ( 31816047) Retinal detachment or retinal break ( 31816047) Rheumatoid arthritis (ACPA-negative) ( 24532677) Skin pigmentation ( 30664655 31315583) Skin pigmentation (conditioned on rs1426654 and rs35397) ( 31315583) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655) Tanning ( 19340012)
Interacting Genes		20 interacting genes: ACTN1 CALM1 CALM2 CALM3 CAMK2A EFNB2 FLNA GPRASP1 HOMER1 HOMER3 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCQ PRKCZ RGS12 SIAH1 TAMALIN
Entrez ID		2915
HPRD ID		04980
Ensembl ID		ENSG00000168959
Uniprot IDs		A8K5P7 P41594
PDB IDs		3LMK 4OO9 5CGC 5CGD 6N4X 6N4Y 6N50 6N51 6N52 7FD8 7FD9 8T6J 8T7H 8T8M 8TAO 8X0B 8X0C 8X0D 8X0E 8X0F 8X0G 8X0H
Enriched GO Terms of Interacting Partners?		Diacylglycerol-dependent Serine/threonine Kinase Activity Calyx Of Held Long-term Synaptic Potentiation Modulation Of Chemical Synaptic Transmission Regulation Of Transport Presynaptic Cytosol Positive Regulation Of Synaptic Transmission Regulation Of Cell Communication Regulation Of Signaling Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Signal Transduction Regulation Of Signal Transduction Regulation Of Metal Ion Transport Protein Serine Kinase Activity Regulation Of Calcium Ion Transport G Protein-coupled Receptor Signaling Pathway Protein Kinase C Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Serine/threonine Kinase Activity Transmembrane Transporter Binding Regulation Of Monoatomic Ion Transport Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Protein Kinase Activity Regulation Of Biological Quality Plasma Membrane Regulation Of Synaptic Plasticity Negative Regulation Of Transmembrane Transport Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Kinase Activity Calcium Channel Regulator Activity Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Regulation Of Sequestering Of Calcium Ion Titin Binding Regulation Of Platelet Activation Cytoplasm Sarcomere Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Histone H3T6 Kinase Activity Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Monoatomic Ion Transmembrane Transport
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