GRM5 and CALM2

Number of citations of the paper that reports this interaction (PMID 9242710)
28

Data Source:
HPRD (in vivo)

		GRM5	CALM2
Gene Name		glutamate receptor, metabotropic 5	calmodulin 2 (phosphorylase kinase, delta)
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Dendritic Spine Dendritic Shaft Extracellular Vesicular Exosome Astrocyte Projection	Spindle Pole Extracellular Region Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Spindle Microtubule Plasma Membrane Sarcomere Growth Cone Vesicle Calcium Channel Complex Extracellular Vesicular Exosome
	Molecular Function	G-protein Coupled Receptor Activity Glutamate Receptor Activity A2A Adenosine Receptor Binding	Calcium Ion Binding Protein Binding Adenylate Cyclase Binding Protein Kinase Binding Protein Domain Specific Binding Nitric-oxide Synthase Regulator Activity Titin Binding Type 3 Metabotropic Glutamate Receptor Binding Thioesterase Binding N-terminal Myristoylation Domain Binding Phospholipase Binding Protein Serine/threonine Kinase Activator Activity Phosphatidylinositol 3-kinase Binding Ion Channel Binding Calcium-dependent Protein Binding Nitric-oxide Synthase Binding Protein Phosphatase Activator Activity
	Biological Process	Activation Of MAPKKK Activity Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Transcription, DNA-templated Protein Phosphorylation Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Glutamate Receptor Signaling Pathway G-protein Coupled Glutamate Receptor Signaling Pathway Synaptic Transmission Learning Locomotory Behavior Negative Regulation Of Locomotion Positive Regulation Of Long-term Neuronal Synaptic Plasticity Cognition Regulation Of Synaptic Transmission, Glutamatergic	Response To Amphetamine Regulation Of Heart Rate Platelet Degranulation Detection Of Calcium Ion Carbohydrate Metabolic Process Glycogen Catabolic Process Glucose Metabolic Process Muscle Contraction Organelle Organization Mitochondrion Organization Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Activation Of Phospholipase C Activity Synaptic Transmission Blood Coagulation Phototransduction, Visible Light Fibroblast Growth Factor Receptor Signaling Pathway Pathogenesis Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Rhodopsin Mediated Signaling Pathway Substantia Nigra Development Regulation Of Rhodopsin Mediated Signaling Pathway Platelet Activation Positive Regulation Of Cyclic Nucleotide Metabolic Process Positive Regulation Of Protein Autophosphorylation Regulation Of Cytokinesis Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Protein Dephosphorylation Fc-epsilon Receptor Signaling Pathway Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Innate Immune Response Nitric Oxide Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Response To Corticosterone Response To Calcium Ion Regulation Of Cardiac Muscle Contraction Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Membrane Organization Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class C/3 (Metabotropic glutamate/pheromone receptors)	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Ca-dependent events CaM pathway Signaling by FGFR in disease Phospholipase C-mediated cascade Signaling by Wnt Platelet degranulation Signaling by EGFRvIII in Cancer CREB phosphorylation through the activation of Ras PLCG1 events in ERBB2 signaling Glucose metabolism DAP12 signaling Synthesis of IP3 and IP4 in the cytosol Myoclonic epilepsy of Lafora Response to elevated platelet cytosolic Ca2+ Glycogen storage diseases Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Signaling by PDGF Calmodulin induced events CaMK IV-mediated phosphorylation of CREB DAP12 interactions Glycogen breakdown (glycogenolysis) Opioid Signalling Activation of Kainate Receptors upon glutamate binding Diseases associated with visual transduction Inositol phosphate metabolism EGFR interacts with phospholipase C-gamma CaMK IV-mediated phosphorylation of CREB Signaling by ERBB2 Signaling by EGFR Signaling by VEGF CREB phosphorylation through the activation of CaMKK Downstream signal transduction Calmodulin induced events CREB phosphorylation through the activation of CaMKII Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Transcriptional activation of mitochondrial biogenesis Metabolism of carbohydrates Platelet activation, signaling and aggregation Adaptive Immune System Transmission across Chemical Synapses Ras activation uopn Ca2+ infux through NMDA receptor Organelle biogenesis and maintenance Cam-PDE 1 activation Translocation of GLUT4 to the plasma membrane VEGFA-VEGFR2 Pathway DAG and IP3 signaling CaM pathway Inactivation, recovery and regulation of the phototransduction cascade Metabolism of nitric oxide VEGFR2 mediated cell proliferation VEGFR2 mediated vascular permeability Activation of NMDA receptor upon glutamate binding and postsynaptic events The phototransduction cascade Downstream signaling of activated FGFR DARPP-32 events eNOS activation and regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Post NMDA receptor activation events Signalling by NGF PLC beta mediated events Smooth Muscle Contraction Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Mitochondrial biogenesis beta-catenin independent WNT signaling Signaling by FGFR eNOS activation Cam-PDE 1 activation Ca2+ pathway Visual phototransduction Activation of CaMK IV PLC-gamma1 signalling FCERI mediated Ca+2 mobilization
Drugs		Acamprosate Rufinamide
Diseases
GWAS		Attention deficit hyperactivity disorder ( 22012869) Tanning ( 19340012)	Dialysis-related mortality ( 21546767)
Protein-Protein Interactions		19 interactors: CALM1 CALM2 CALM3 DYT10 EFNB2 FLNA GPRASP1 GRASP HOMER1 HOMER3 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCQ PRKCZ RGS12 SIAH1	40 interactors: ADAMTS12 ADCY8 AKAP9 ASCL2 C11orf65 CACNA1A CALD1 CAMTA2 CCND2 DLG1 EDF1 EGFR ESR1 ESR2 GRM5 GRM7 INSR INVS IQCB1 IQCE IQGAP3 KCNIP3 KCNQ2 KCNQ3 KCNQ5 KIAA1683 MARCKS MRPL20 MYF5 MYF6 MYO6 MYOD1 MYOG NEUROD1 PCNT PPEF1 PPEF2 RAB3B RPSA TCF4
Entrez ID		2915	805
HPRD ID		04980	00242
Ensembl ID		ENSG00000168959	ENSG00000143933
Uniprot IDs		A8K5P7 P41594	B4DJ51 P62158
PDB IDs		3LMK	1AJI 1CDL 1CLL 1CTR 1IWQ 1J7O 1J7P 1K90 1K93 1L7Z 1LVC 1NKF 1PK0 1S26 1SK6 1SW8 1WRZ 1XFU 1XFV 1XFW 1XFX 1XFY 1XFZ 1Y6W 1YR5 1YRT 1YRU 1ZOT 1ZUZ 2BE6 2F3Y 2F3Z 2HF5 2I08 2JZI 2K0E 2K0F 2K0J 2K61 2KNE 2KUG 2KUH 2L53 2L7L 2LGF 2LL6 2LL7 2LQC 2LQP 2LV6 2M55 2R28 2V01 2V02 2VAY 2W73 2WEL 2X0G 2Y4V 3BYA 3DVE 3DVJ 3DVK 3DVM 3EWT 3EWV 3G43 3HR4 3J41 3O77 3O78 3OXQ 3SUI 3UCT 3UCW 3UCY 4DCK 4DJC 4GOW
Enriched GO Terms of Interacting Partners?		Platelet Activation Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Blood Coagulation Hemostasis Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Vascular Endothelial Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Rhodopsin Mediated Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Negative Regulation Of Insulin Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Insulin Receptor Signaling Pathway Regulation Of Signaling Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Dephosphorylation Regulation Of Cellular Response To Insulin Stimulus Phototransduction, Visible Light Signal Transduction Synaptic Transmission Cellular Response To Growth Factor Stimulus Activation Of Adenylate Cyclase Activity Cell-cell Signaling Response To Growth Factor Detection Of Visible Light Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Light Stimulus Phototransduction Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Transport Signaling Regulation Of High Voltage-gated Calcium Channel Activity Intracellular Signal Transduction Cell Communication	Positive Regulation Of Skeletal Muscle Fiber Development Cell-cell Signaling Synaptic Transmission Tissue Development Epithelium Development Positive Regulation Of Cellular Metabolic Process Muscle Cell Fate Commitment Positive Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Fusion Cellular Response To Estradiol Stimulus Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Regulation Of Myoblast Fusion Regulation Of Cellular Process Regulation Of Skeletal Muscle Tissue Development System Development Organ Development Cell Differentiation Cellular Response To Estrogen Stimulus Positive Regulation Of Skeletal Muscle Tissue Development Multicellular Organismal Development Regulation Of Signaling Regulation Of Ion Transmembrane Transport Organ Morphogenesis Positive Regulation Of Myotube Differentiation Anatomical Structure Development Regulation Of Ion Transport Embryonic Organ Development Positive Regulation Of Metabolic Process Regulation Of Myoblast Differentiation Anatomical Structure Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Cell Development Response To Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Developmental Process Generation Of Neurons Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Myotube Differentiation Regulation Of Striated Muscle Tissue Development Skeletal Muscle Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Transcription, DNA-templated Activation Of Protein Kinase Activity Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Muscle Tissue Development Negative Regulation Of Signal Transduction Neurogenesis
Tagcloud ?		asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm1 grm2 grm3 grm4 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi	100nm 48h 81m anapc13 carcinogenic diarrheic drawing exhaustive explanation hn1 malat1 mapre2 mllt11 molluscs oa okadaic pathologies poisoning positives pttg1 rodents sga shellfish shsy5y ssh subtractive tax1bp1 toxins tumourigenesis
Tagcloud (Difference) ?		asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm1 grm2 grm3 grm4 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi	100nm 48h 81m anapc13 carcinogenic diarrheic drawing exhaustive explanation hn1 malat1 mapre2 mllt11 molluscs oa okadaic pathologies poisoning positives pttg1 rodents sga shellfish shsy5y ssh subtractive tax1bp1 toxins tumourigenesis
Tagcloud (Intersection) ?