ING2 and COPS2

Number of citations of the paper that reports this interaction (PubMedID 17929852)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ING2	COPS2
Description		inhibitor of growth family member 2	COP9 signalosome subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane CCAAT-binding Factor Complex Sin3-type Complex	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Protein-containing Complex
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone Deacetylase Regulator Activity Phosphatidylinositol Binding Protein-containing Complex Binding Metal Ion Binding Histone H3K4me3 Reader Activity Histone Reader Activity	Transcription Corepressor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of DNA-templated Transcription DNA Damage Response Male Meiosis I Signal Transduction Spermatogenesis Spermatid Development Flagellated Sperm Motility Negative Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of DNA-templated Transcription Male Germ-line Stem Cell Asymmetric Division Seminiferous Tubule Development Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Regulation Of Cellular Senescence Negative Regulation Of Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Protein Deneddylation Inner Cell Mass Cell Proliferation Trophectodermal Cell Proliferation Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Neuron Differentiation Skeletal Muscle Cell Differentiation Protein Neddylation Negative Regulation Of DNA-templated Transcription Regulation Of Protein Neddylation
Pathways		SUMOylation of transcription cofactors PI5P Regulates TP53 Acetylation	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation RHOBTB1 GTPase cycle
Drugs
Diseases
GWAS			Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)
Interacting Genes		8 interacting genes: APP COPS2 EP300 H3-4 H4C16 SMAD1 SMURF1 SMURF2	39 interacting genes: COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 CSNK2A1 CUL4A CUL5 EP300 GFER GPS1 H3C1 H4C1 ING1 ING2 IP6K1 IRF8 MAP3K10 MAPK8 NCOR1 NIF3L1 NR0B1 NR2F1 OGT PRKD1 PSMD11 RARA RND1 RXRA SENP8 SIN3A SIN3B THRA THRB TP53 UBC VDR ZNF446
Entrez ID		3622	9318
HPRD ID		05021	05146
Ensembl ID		ENSG00000168556	ENSG00000166200
Uniprot IDs		B2RA15 Q9H160	P61201 Q59EL2
PDB IDs			4D10 4D18 4WSN 6A73 6R6H 6R7F 6R7H 6R7I 6R7N 8H38 8H3A 8H3F
Enriched GO Terms of Interacting Partners?		Regulation Of Developmental Process Protein-containing Complex Regulation Of Cell Differentiation I-SMAD Binding Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex Regulation Of Plasma Membrane Bounded Cell Projection Organization Growth Cone Lamellipodium Chromatin Remodeling Myeloid Cell Development Chromatin Organization Regulation Of Cell Projection Organization Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Developmental Process Protein Heterodimerization Activity Positive Regulation Of Cell Differentiation Nucleoplasm Protein Localization To Chromatin Wnt Signaling Pathway Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Cell Projection Organization Histone Crotonyltransferase Activity Regulation Of Cellular Response To Growth Factor Stimulus Transcription By RNA Polymerase II Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of BMP Signaling Pathway Engulfment Of Target By Autophagosome SMAD Binding Non-canonical Wnt Signaling Pathway Regulation Of ATP Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of MiRNA Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Purine Nucleotide Metabolic Process BMP Signaling Pathway Structural Constituent Of Chromatin Acetylcholine Receptor Activator Activity	Protein Deneddylation Regulation Of Protein Neddylation Protein Neddylation COP9 Signalosome Nucleoplasm Sin3-type Complex Negative Regulation Of Transcription By RNA Polymerase II Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Removal Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Nuclear Receptor Activity MRNA Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Modification Process Chromatin Regulation Of Post-translational Protein Modification MRNA Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Rhythmic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Histone Deacetylase Regulator Activity Positive Regulation Of RNA Metabolic Process Post-translational Protein Modification Regulation Of Thyroid Hormone Receptor Signaling Pathway DeNEDDylase Activity Negative Regulation Of Stem Cell Population Maintenance Retinoic Acid-responsive Element Binding Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Intracellular Receptor Signaling Pathway Protein Metabolic Process Regulation Of Protein Modification Process Cytosol
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