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ING2 and HIST4H4
Number of citations of the paper that reports this interaction (PMID
16782091
)
10
Data Source:
HPRD
(in vivo)
ING2
HIST4H4
Gene Name
inhibitor of growth family, member 2
histone cluster 4, H4
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Sin3 Complex
CCAAT-binding Factor Complex
Nuclear Chromosome
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Membrane
Protein Complex
Extracellular Vesicular Exosome
Molecular Function
DNA Binding
Chromatin Binding
Protein Binding
Zinc Ion Binding
Protein Complex Binding
Methylated Histone Binding
Phosphatidylinositol Binding
DNA Binding
Protein Binding
Histone Demethylase Activity (H4-K20 Specific)
Poly(A) RNA Binding
Protein Heterodimerization Activity
Biological Process
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Male Meiosis I
Signal Transduction
Spermatogenesis
Spermatid Development
Negative Regulation Of Cell Proliferation
Chromatin Modification
Sperm Motility
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Growth
Positive Regulation Of Apoptotic Process
Positive Regulation Of Transcription, DNA-templated
Male Germ-line Stem Cell Asymmetric Division
Seminiferous Tubule Development
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Regulation Of Cellular Senescence
Regulation Of Response To DNA Damage Stimulus
Chromatin Silencing At RDNA
Mitotic Cell Cycle
Telomere Maintenance
Chromatin Organization
Nucleosome Assembly
DNA Replication-dependent Nucleosome Assembly
DNA Replication-independent Nucleosome Assembly
Gene Expression
DNA Methylation On Cytosine
CENP-A Containing Nucleosome Assembly
Histone H4-K20 Demethylation
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
PKMTs methylate histone lysines
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
HDMs demethylate histones
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
Telomere Maintenance
Nucleosome assembly
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Pubertal anthropometrics (
23449627
)
Protein-Protein Interactions
9 interactors:
APP
COPS2
EP300
HIST3H3
HIST4H4
SMAD1
SMURF1
SMURF2
SUMO1
52 interactors:
ANP32A
ARID4A
ASF1A
ASF1B
BRD2
BRD4
BRD7
CBX5
CDY1
COPRS
CREBBP
DAXX
DNTTIP2
EP300
GADD45A
HAT1
HDAC6
HDAC8
HDAC9
ING1
ING2
KAT2A
KAT2B
KAT6A
L3MBTL1
LRWD1
MSL3
NCOA2
NCOA3
NOC2L
NSD1
ORC2
ORC3
ORC4
ORC5
PRMT1
PRMT6
RAG1
RPS6KA5
SAP30
SET
SETD8
SETDB1
SIAH1
SMARCA5
TAF1A
TP53BP1
UBE2I
UCHL5
USP16
VHL
WDR5
Entrez ID
3622
121504
HPRD ID
05021
13662
Ensembl ID
ENSG00000168556
ENSG00000197837
Uniprot IDs
Q9H160
B2R4R0
P62805
PDB IDs
2BQZ
2CV5
2KWN
2KWO
2LVM
2QQS
2RNY
2RS9
3A6N
3AFA
3AN2
3AV1
3AV2
3AYW
3AZE
3AZF
3AZG
3AZH
3AZI
3AZJ
3AZK
3AZL
3AZM
3AZN
3CFS
3CFV
3F9W
3F9X
3F9Y
3F9Z
3NQJ
3NQU
3O36
3QZS
3QZT
3QZV
3R45
3UVW
3UVX
3UVY
3UW9
3W96
3W97
3W98
3W99
4GQB
4H9N
4H9O
4H9P
4H9Q
4H9R
4H9S
4HGA
Enriched GO Terms of Interacting Partners
?
Cellular Protein Modification Process
Negative Regulation Of Gene Expression
Ubiquitin-dependent SMAD Protein Catabolic Process
BMP Signaling Pathway
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Cellular Protein Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Nucleobase-containing Compound Metabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Regulation Of Gene Expression
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Negative Regulation Of Biosynthetic Process
Nitrogen Compound Metabolic Process
Protein Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Binding
Striated Muscle Tissue Development
Muscle Tissue Development
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Organic Substance
Cell Surface Receptor Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Telomere Maintenance
Histone H2B Acetylation
Cellular Metabolic Process
Gene Expression
Posttranscriptional Regulation Of Gene Expression
Signal Transduction
Regulation Of Metabolic Process
Gene Silencing
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Synaptic Growth At Neuromuscular Junction
Signaling
Defense Response
Cellular Response To Growth Factor Stimulus
Chromatin Organization
Chromatin Modification
Chromosome Organization
Histone Modification
Regulation Of Gene Expression
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Peptidyl-lysine Modification
Regulation Of RNA Metabolic Process
Cellular Macromolecule Biosynthetic Process
Organelle Organization
Macromolecule Biosynthetic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Negative Regulation Of Gene Expression
Nitrogen Compound Metabolic Process
Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Peptidyl-amino Acid Modification
Gene Expression
RNA Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Histone Acetylation
Internal Peptidyl-lysine Acetylation
Peptidyl-lysine Acetylation
Internal Protein Amino Acid Acetylation
Protein Acetylation
Cellular Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Protein Modification Process
Chromatin Assembly Or Disassembly
Positive Regulation Of Macromolecule Biosynthetic Process
Chromatin Assembly
Positive Regulation Of Transcription, DNA-templated
Histone H3-K9 Modification
Histone Methylation
Positive Regulation Of Gene Expression
Cell Cycle
Nucleosome Assembly
DNA Packaging
Tagcloud
?
acceptor
acetyltransferase
alignment
consensus
consequently
deacetylase
dgcr8
e195a
e3
ing1
ing1b
ing3
ings
isg15
k193
ligase
marks
mislocalized
pdsm
phosphomimic
pias4
preferred
reveals
s199d
stoichiometric
sumo
sumoylation
suppressors
Tagcloud (Difference)
?
acceptor
acetyltransferase
alignment
consensus
consequently
deacetylase
dgcr8
e195a
e3
ing1
ing1b
ing3
ings
isg15
k193
ligase
marks
mislocalized
pdsm
phosphomimic
pias4
preferred
reveals
s199d
stoichiometric
sumo
sumoylation
suppressors
Tagcloud (Intersection)
?