LTK and MTMR14

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		LTK	MTMR14
Description		leukocyte receptor tyrosine kinase	myotubularin related protein 14
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Receptor Complex	Ruffle Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Receptor Signaling Protein Tyrosine Kinase Activator Activity	Phosphatidylinositol-3-phosphate Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity
	Biological Process	Protein Phosphorylation Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Population Proliferation Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Retinoic Acid	Phosphatidylinositol Biosynthetic Process Macroautophagy
Pathways		Signaling by LTK	Macroautophagy Synthesis of PIPs at the plasma membrane
Drugs		Fostamatinib
Diseases
GWAS		High density lipoprotein cholesterol levels ( 31928498) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lymphocyte percentage of white cells ( 32888494) Type 2 diabetes ( 30297969) Urinary albumin excretion (no hypertensive medication) ( 30220432)	Daytime sleep phenotypes ( 27126917)
Interacting Genes		6 interacting genes: CBL DUSP6 MTMR14 PIK3C2B PTPN1 SHC1	10 interacting genes: APP CFTR ENO3 EPHA1 EPHA7 EPHB2 LTK TIE1 TP53BP2 UBC
Entrez ID		4058	64419
HPRD ID		01052	08654
Ensembl ID		ENSG00000062524	ENSG00000163719
Uniprot IDs		P29376	Q8NCE2 Q8WYY9
PDB IDs		7NX0 7NX1
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Binding Receptor Tyrosine Kinase Binding Response To Growth Factor Response To Platelet-derived Growth Factor Cellular Response To Platelet-derived Growth Factor Stimulus Peptidyl-tyrosine Dephosphorylation Insulin Receptor Binding Cellular Response To Growth Factor Stimulus Response To Nerve Growth Factor Cellular Response To Nerve Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Phosphotyrosine Residue Binding Negative Regulation Of ERK1 And ERK2 Cascade Insulin Receptor Signaling Pathway Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Response To Nutrient Levels Protein Tyrosine Phosphatase Activity Phosphate-containing Compound Metabolic Process Phosphatidylinositol Biosynthetic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Shc-EGFR Complex Cellular Response To Hypoxia Cytosol Phosphoprotein Phosphatase Activity Dephosphorylation Phosphatidylinositol Metabolic Process Cellular Response To Decreased Oxygen Levels Response To Stress Regulation Of MAPK Cascade Cellular Response To Oxygen Levels Regulation Of Rap Protein Signal Transduction Negative Regulation Of MAPK Cascade Macroautophagy Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Insulin Receptor Recycling Positive Regulation Of Cell Proliferation In Bone Marrow Epidermal Growth Factor Binding Intracellular Signal Transduction Glycerophospholipid Biosynthetic Process Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Regulation Of Cell Proliferation In Bone Marrow Ubiquitin-dependent Endocytosis MAP Kinase Tyrosine Phosphatase Activity Lipid Kinase Activity Sorting Endosome Neurotrophin TRKA Receptor Binding Regulation Of Intracellular Signal Transduction	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Transmembrane-ephrin Receptor Activity Ephrin Receptor Activity Receptor Complex Ephrin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Activity Kinase Activity Axon Guidance Receptor Activity Neuron Projection Maintenance Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Postsynapse Organization Positive Regulation Of Long-term Synaptic Potentiation ATP Binding Retinal Ganglion Cell Axon Guidance Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synapse Assembly Ephrin Receptor Binding Plasma Membrane Regulation Of Developmental Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Nucleotide Binding Neuron Projection Organization Regulation Of Long-term Synaptic Potentiation Hippocampal Mossy Fiber To CA3 Synapse Neuron Recognition Amyloid-beta Complex Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Neuronal Synaptic Plasticity Regulation Of Cell Junction Assembly Growth Cone Lamellipodium Regulation Of Cell Projection Organization Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To CAMP Cellular Response To Amyloid-beta Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Negative Regulation Of Axonogenesis Peptidyl-tyrosine Phosphorylation Branching Involved In Lymph Vessel Morphogenesis Cell Surface Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Response To Amyloid-beta Regulation Of Synapse Organization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
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