LTK and PIK3C2B

Number of citations of the paper that reports this interaction (PMID 8084603)
4

Data Source:
HPRD (in vivo)

		LTK	PIK3C2B
Gene Name		leukocyte receptor tyrosine kinase	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane	Nucleus Endoplasmic Reticulum Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Endocytic Vesicle
	Molecular Function	Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity ATP Binding	Lipid Kinase Activity Protein Binding ATP Binding 1-phosphatidylinositol-3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Phosphatidylinositol Binding
	Biological Process	Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Negative Regulation Of Apoptotic Process Cellular Response To Retinoic Acid	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Biological_process Phosphatidylinositol-3-phosphate Biosynthetic Process Protein Kinase B Signaling Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation Phosphatidylinositol-mediated Signaling
Pathways			Synthesis of PIPs at the plasma membrane Metabolism of lipids and lipoproteins Phospholipid metabolism PI Metabolism
Drugs
Diseases
GWAS			Breast cancer ( 23535733) Prostate cancer ( 23535732)
Protein-Protein Interactions		4 interactors: CBL PIK3C2B PTPN1 SHC1	9 interactors: EGFR ERBB2 GRB2 ITSN1 ITSN2 LTK PDGFRB SHC1 YWHAQ
Entrez ID		4058	5287
HPRD ID		01052	04160
Ensembl ID		ENSG00000062524	ENSG00000133056
Uniprot IDs		P29376	A2RUF7 F5GWN5 O00750
PDB IDs
Enriched GO Terms of Interacting Partners?		Actin Cytoskeleton Reorganization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity Response To Unfolded Protein Enzyme Linked Receptor Protein Signaling Pathway Insulin Receptor Signaling Pathway Response To Endoplasmic Reticulum Stress Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Endocytosis Cellular Response To Fibroblast Growth Factor Stimulus Platelet Activation Response To Fibroblast Growth Factor Cellular Response To Insulin Stimulus Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Platelet-derived Growth Factor Receptor-beta Signaling Pathway Response To Insulin Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of Vesicle-mediated Transport Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Blood Coagulation Cellular Response To Organic Substance Hemostasis Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Peptide Hormone Cellular Response To Organonitrogen Compound Signal Transduction Response To Peptide Signaling Regulation Of Body Fluid Levels Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus Cell Communication Regulation Of Interferon-gamma-mediated Signaling Pathway Wound Healing Response To Growth Factor Actin Cytoskeleton Organization JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Phosphatidylinositol-3-phosphate Biosynthetic Process Regulation Of MAPK Cascade	Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Phosphatidylinositol-mediated Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Fc-epsilon Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Hydrolase Activity Cellular Response To Organic Substance Regulation Of Signaling Positive Regulation Of MAP Kinase Activity Chemotaxis Regulation Of MAPK Cascade Locomotion Regulation Of Phosphorylation Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of MAP Kinase Activity Regulation Of ERBB Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Innate Immune Response Positive Regulation Of Phosphorylation System Development Regulation Of Immune Response Axon Guidance Peptidyl-amino Acid Modification Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Positive Regulation Of DNA Metabolic Process Multicellular Organismal Development Cell Surface Receptor Signaling Pathway
Tagcloud ?		aizawa biol chem depolymerizing detyrosinated dramatic grew map4 microtubule mock mt mts naive nocodazole organellar polymer polymerization polymerizing potently slowly stabilization stabilized stably taxol transfectants translationally tubulin ubiquitously vertebrate	adj adjustment aggressiveness allele attributable consortium familial fatal gleason institute nearby per phosphatidylinositol pi3k pik3ap1 pik3r3 pooled prostate rs7556371 snp snps strengthened stronger strongest tertile top trend
Tagcloud (Difference) ?		aizawa biol chem depolymerizing detyrosinated dramatic grew map4 microtubule mock mt mts naive nocodazole organellar polymer polymerization polymerizing potently slowly stabilization stabilized stably taxol transfectants translationally tubulin ubiquitously vertebrate	adj adjustment aggressiveness allele attributable consortium familial fatal gleason institute nearby per phosphatidylinositol pi3k pik3ap1 pik3r3 pooled prostate rs7556371 snp snps strengthened stronger strongest tertile top trend
Tagcloud (Intersection) ?