RAPGEF1 and RAP1B

Number of citations of the paper that reports this interaction (PMID 8524240)
62

Data Source:
HPRD (in vitro, in vivo)

		RAPGEF1	RAP1B
Gene Name		Rap guanine nucleotide exchange factor (GEF) 1	RAP1B, member of RAS oncogene family
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endosome Early Endosome Cytosol	Intracellular Lipid Particle Cytosol Plasma Membrane Cell-cell Junction Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Rap Guanyl-nucleotide Exchange Factor Activity SH3 Domain Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Complex Binding
	Biological Process	Activation Of MAPKK Activity Blood Vessel Development Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Neuron Projection Development Single Organismal Cell-cell Adhesion Rap Protein Signal Transduction Positive Regulation Of Rap GTPase Activity Nerve Growth Factor Signaling Pathway Negative Regulation Of Ras Protein Signal Transduction Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Protein Kinase B Signaling Establishment Of Endothelial Barrier Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Junction Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Neural Precursor Cell Proliferation	Blood Coagulation Cell Proliferation Microvillus Assembly Platelet Activation Rap Protein Signal Transduction Negative Regulation Of Calcium Ion-dependent Exocytosis Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Regulation Of Cell Junction Assembly Regulation Of Establishment Of Cell Polarity Negative Regulation Of Synaptic Vesicle Exocytosis
Pathways		Signaling by PDGF Signalling to ERKs Signalling by NGF Prolonged ERK activation events Signaling by Interleukins Downstream signal transduction Regulation of signaling by CBL Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Interleukin-3, 5 and GM-CSF signaling Frs2-mediated activation	Rap1 signalling p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) Adaptive Immune System
Drugs
Diseases
GWAS			White blood cell count ( 20139978)
Protein-Protein Interactions		16 interactors: ABL1 ATXN1 BCAR1 CRK CRKL GRB2 HCK HRAS MBIP NEDD9 RAP1B RHOQ RPS15 RRAS2 SHC1 SLC20A1	29 interactors: A2M ALAS1 APLP1 APP CCT7 CHGB CSAD DDAH2 FAF1 HRAS KMT2B LRIF1 PDHB PKM PRKACA RAB7B RALGDS RAPGEF1 RASSF5 RGL2 RGS2 RPTOR SDF4 SMURF2 TLE1 TP53 UNC119 ZDHHC17 ZNF135
Entrez ID		2889	5908
HPRD ID		02627	01546
Ensembl ID		ENSG00000107263	ENSG00000127314
Uniprot IDs		Q13905 Q68DL3	B7ZAY2 P61224
PDB IDs			3BRW 3CF6 4DXA 4HDO 4HDQ
Enriched GO Terms of Interacting Partners?		Cellular Response To Organonitrogen Compound Neurotrophin Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Insulin Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Response To Organonitrogen Compound Cellular Response To Peptide Enzyme Linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Blood Coagulation Hemostasis Response To Peptide Hormone Immune Response-regulating Signaling Pathway Response To Peptide Fc Receptor Signaling Pathway Response To Insulin Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Regulation Of Body Fluid Levels Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Cellular Response To Hormone Stimulus Epidermal Growth Factor Receptor Signaling Pathway Wound Healing Small GTPase Mediated Signal Transduction Response To Growth Factor ERBB Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Phosphorus Metabolic Process Signaling Regulation Of Signal Transduction Platelet Activation Regulation Of Actin Filament-based Process Response To Wounding Cell Communication Regulation Of Protein Kinase Activity Positive Regulation Of MAPK Cascade Regulation Of Kinase Activity Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Cytoskeleton Organization Regulation Of Immune Response Response To Organic Substance Signal Transduction	Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Response To Light Stimulus Regulation Of Kinase Activity Intracellular Signal Transduction Ras Protein Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Signal Transduction Regulation Of Phosphorylation Response To Radiation Programmed Cell Death Cell Death Death Negative Regulation Of Signal Transduction Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Component Biogenesis Cell Communication Positive Regulation Of Catalytic Activity Negative Regulation Of Signaling Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Negative Regulation Of Hydrolase Activity Apoptotic Process Regulation Of Peptidyl-tyrosine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Blood Coagulation Hemostasis Neurotrophin Signaling Pathway Positive Regulation Of Hydrolase Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Kinase Activity Cellular Response To Organonitrogen Compound Response To Abiotic Stimulus Positive Regulation Of Kinase Activity Regulation Of Cellular Component Organization
Tagcloud ?		abl abrogated c3g catalytically colocalized crk delineate dephosphorylation forskolin golgi guanine imr interacted neurite neuroblastoma noncatalytic outgrowth pc3g pervanadate phospho ptp ptpn2 reorganization src substrate tc tc48 vanadate y504	adp alphaiibbeta3 alzheimer apyrase atherothrombotic autocrine besides ca2 cerebrovascular collectively complement dense discovered discoveries fibrinogen granule gtpase integrin manage marginal p2y peptides platelet platelets signalling stimulant stimulates syk thrombus
Tagcloud (Difference) ?		abl abrogated c3g catalytically colocalized crk delineate dephosphorylation forskolin golgi guanine imr interacted neurite neuroblastoma noncatalytic outgrowth pc3g pervanadate phospho ptp ptpn2 reorganization src substrate tc tc48 vanadate y504	adp alphaiibbeta3 alzheimer apyrase atherothrombotic autocrine besides ca2 cerebrovascular collectively complement dense discovered discoveries fibrinogen granule gtpase integrin manage marginal p2y peptides platelet platelets signalling stimulant stimulates syk thrombus
Tagcloud (Intersection) ?