RAPGEF1

Gene Name		Rap guanine nucleotide exchange factor (GEF) 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endosome Early Endosome Cytosol
	Molecular Function	Protein Binding Rap Guanyl-nucleotide Exchange Factor Activity SH3 Domain Binding
	Biological Process	Activation Of MAPKK Activity Blood Vessel Development Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Neuron Projection Development Single Organismal Cell-cell Adhesion Rap Protein Signal Transduction Positive Regulation Of Rap GTPase Activity Nerve Growth Factor Signaling Pathway Negative Regulation Of Ras Protein Signal Transduction Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Protein Kinase B Signaling Establishment Of Endothelial Barrier Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Junction Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		Signaling by PDGF Signalling to ERKs Signalling by NGF Prolonged ERK activation events Signaling by Interleukins Downstream signal transduction Regulation of signaling by CBL Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Interleukin-3, 5 and GM-CSF signaling Frs2-mediated activation
Drugs
Diseases
GWAS
Protein-protein Interactions		16 interactors: ABL1 ATXN1 BCAR1 CRK CRKL GRB2 HCK HRAS MBIP NEDD9 RAP1B RHOQ RPS15 RRAS2 SHC1 SLC20A1
Entrez ID		2889
HPRD ID		02627
Ensembl ID		ENSG00000107263
Uniprot IDs		Q13905 Q68DL3
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Organonitrogen Compound Neurotrophin Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Insulin Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Response To Organonitrogen Compound Cellular Response To Peptide Enzyme Linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Blood Coagulation Hemostasis Response To Peptide Hormone Immune Response-regulating Signaling Pathway Response To Peptide Fc Receptor Signaling Pathway Response To Insulin Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Regulation Of Body Fluid Levels Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Cellular Response To Hormone Stimulus Epidermal Growth Factor Receptor Signaling Pathway Wound Healing Small GTPase Mediated Signal Transduction Response To Growth Factor ERBB Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Phosphorus Metabolic Process Signaling Regulation Of Signal Transduction Platelet Activation Regulation Of Actin Filament-based Process Response To Wounding Cell Communication Regulation Of Protein Kinase Activity Positive Regulation Of MAPK Cascade Regulation Of Kinase Activity Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Cytoskeleton Organization Regulation Of Immune Response Response To Organic Substance Signal Transduction
Tagcloud ?		abl abrogated c3g catalytically colocalized crk delineate dephosphorylation forskolin golgi guanine imr interacted neurite neuroblastoma noncatalytic outgrowth pc3g pervanadate phospho ptp ptpn2 reorganization src substrate tc tc48 vanadate y504