APOD and SIGLECL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		APOD	SIGLECL1
Description		apolipoprotein D	SIGLEC family like 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Cytosolic Ribosome Dendrite Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome	Membrane
	Molecular Function	Lipid Transporter Activity Protein Binding Lipid Binding Cholesterol Binding	Protein Binding
	Biological Process	Response To Reactive Oxygen Species Angiogenesis Glucose Metabolic Process Lipid Metabolic Process Lipid Transport Response To Stress Brain Development Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Peripheral Nervous System Axon Regeneration Tissue Regeneration Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Smooth Muscle Cell Proliferation Response To Axon Injury Negative Regulation Of Focal Adhesion Assembly Negative Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of T Cell Migration
Pathways		Transport of fatty acids NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs		Vitamin A Copper
Diseases
GWAS		HDL cholesterol levels ( 32203549)	Adult body size ( 32376654)
Interacting Genes		51 interacting genes: AIG1 APH1A APOA2 AQP9 ATP6V0B ATP6V0E1 BCL2L13 BIK CD53 CD79A CLDN7 CLEC10A CPLX4 CREB3 CREB3L1 ERGIC3 EVI2B FAM209A FFAR2 FKBP7 FPR2 GDAP1 GJA8 GORAB GPR151 GPR42 GPX8 KCNJ6 KIR2DL3 LEPR LMNA MFF MGST3 MTERF2 MTIF3 NCAPH2 PDZK1IP1 POLR2M RHBDL1 SHBG SIGLECL1 SLC10A6 SLC35H1 TEX29 TMEM237 TMEM31 TMEM45B TMEM52B TMEM79 VAPA VSIR	2 interacting genes: APOD EMP3
Entrez ID		347	284369
HPRD ID		00134	08275
Ensembl ID		ENSG00000189058	ENSG00000179213
Uniprot IDs		P05090	B7ZLS6 Q8N7X8
PDB IDs		2HZQ 2HZR
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding	Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of Lipoprotein Metabolic Process Peripheral Nervous System Axon Regeneration Negative Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of T Cell Migration Bleb Assembly Negative Regulation Of Lymphocyte Migration Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Lipoprotein Metabolic Process Negative Regulation Of Protein Import Into Nucleus Plasma Membrane Bounded Cell Projection Organization Axon Regeneration Negative Regulation Of Focal Adhesion Assembly Lipid Transporter Activity Negative Regulation Of Chemokine Production Neuron Projection Regeneration Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Intracellular Protein Transport Negative Regulation Of Mononuclear Cell Migration Cell Projection Organization Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Protein Localization To Nucleus Response To Axon Injury Axon Development Negative Regulation Of Leukocyte Migration Negative Regulation Of Smooth Muscle Cell Proliferation Cholesterol Binding Regulation Of T Cell Migration Negative Regulation Of Cytokine Production Involved In Inflammatory Response Tissue Regeneration Negative Regulation Of Intracellular Transport Regulation Of Protein Import Into Nucleus Negative Regulation Of Cell-substrate Adhesion Regulation Of Lymphocyte Migration Regulation Of Focal Adhesion Assembly Regulation Of Cell-substrate Junction Organization Regulation Of Cytokine Production Involved In Inflammatory Response Cytosolic Ribosome Regulation Of Chemokine Production Negative Regulation Of Lipid Metabolic Process Regulation Of Cell-matrix Adhesion Glucose Metabolic Process Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Protein Transport Regeneration Negative Regulation Of Establishment Of Protein Localization
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