APOD and VAPA

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		APOD	VAPA
Gene Name		apolipoprotein D	VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Cytosolic Ribosome Dendrite Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Tight Junction Microtubule Cytoskeleton Integral Component Of Membrane Vesicle Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site
	Molecular Function	Lipid Transporter Activity Protein Binding Cholesterol Binding	Signal Transducer Activity Protein Binding Microtubule Binding Protein Domain Specific Binding FFAT Motif Binding Protein Heterodimerization Activity
	Biological Process	Response To Reactive Oxygen Species Angiogenesis Glucose Metabolic Process Lipid Metabolic Process Lipid Transport Brain Development Aging Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Peripheral Nervous System Axon Regeneration Tissue Regeneration Negative Regulation Of Protein Import Into Nucleus Response To Drug Negative Regulation Of Smooth Muscle Cell Proliferation Response To Axon Injury Negative Regulation Of Focal Adhesion Assembly Negative Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of T Cell Migration	Sphingolipid Metabolic Process ER To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Signal Transduction Cell Death Sphingolipid Biosynthetic Process Neuron Projection Development Protein Folding In Endoplasmic Reticulum Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Small Molecule Metabolic Process Positive Regulation By Host Of Viral Release From Host Cell Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Genome Replication Membrane Fusion Protein Localization To Endoplasmic Reticulum COPII-coated Vesicle Budding
Pathways		Transport of vitamins, nucleosides, and related molecules SLC-mediated transmembrane transport Transport of fatty acids Orphan transporters	Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS			Pulmonary function (interaction) ( 23284291)
Protein-Protein Interactions		5 interactors: APOA2 LEPR POLR2M SHBG VAPA	15 interactors: ADRB2 APOD APP CACNG1 EGFR GPR128 NSF OPRM1 OSBP RMDN3 SIK1 VAMP1 VAMP2 VAPB ZBTB22
Entrez ID		347	9218
HPRD ID		00134	09299
Ensembl ID		ENSG00000189058	ENSG00000101558
Uniprot IDs		P05090	Q9P0L0
PDB IDs		2APD 2HZQ 2HZR	2RR3
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Growth Hormone Receptor Signaling Pathway Maintenance Of ER Location Primary Spermatocyte Growth Negative Regulation Of Cholesterol Transporter Activity Cholesterol Metabolic Process Sterol Metabolic Process Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Release From Host Cell Regulation Of Cholesterol Transporter Activity Negative Regulation Of Cholesterol Import Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Endoplasmic Reticulum Localization Regulation Of Cholesterol Import Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Process Diacylglycerol Catabolic Process Steroid Metabolic Process High-density Lipoprotein Particle Clearance Regulation Of Intestinal Cholesterol Absorption Protein Oxidation Lipid Metabolic Process Positive Regulation Of Viral Release From Host Cell Negative Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Interleukin-8 Biosynthetic Process High-density Lipoprotein Particle Assembly Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Cholesterol Esterification Peptidyl-methionine Modification Alcohol Metabolic Process Regulation Of Cholesterol Esterification Negative Regulation Of Cholesterol Transport Triglyceride-rich Lipoprotein Particle Remodeling Negative Regulation Of Gluconeogenesis Phospholipid Efflux Regulation Of Interleukin-8 Biosynthetic Process Low-density Lipoprotein Particle Remodeling Negative Regulation Of Hydrolase Activity Regulation Of Cytokine Secretion Involved In Immune Response High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Negative Regulation Of Lipase Activity Reverse Cholesterol Transport Diacylglycerol Metabolic Process Regulation Of Protein Localization To Cell Surface Positive Regulation Of Viral Genome Replication COPII-coated Vesicle Budding Regulation Of Viral Release From Host Cell Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Lipid Transport	Metal Ion Homeostasis Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cellular Localization Exocytosis Membrane Fusion Cellular Metal Ion Homeostasis Golgi To Plasma Membrane Protein Transport Establishment Of Localization In Cell Homeostatic Process Membrane Organization Cellular Cation Homeostasis Chemical Homeostasis Cellular Ion Homeostasis Vesicle-mediated Transport Transport Intracellular Transport Golgi To Plasma Membrane Transport Secretion By Cell Cellular Chemical Homeostasis Vesicle Organization Regulation Of Cellular Localization Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Vasodilation Establishment Of Protein Localization To Membrane Vesicle Fusion Regulation Of Ion Transport Regulation Of Protein Transport Secretion Regulation Of Intracellular Protein Transport Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Golgi Vesicle Transport Regulation Of Adenylate Cyclase Activity Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Establishment Of Protein Localization Negative Regulation Of Wnt Protein Secretion Alkanesulfonate Metabolic Process Negative Regulation Of T Cell Migration Negative Regulation Of Lipoprotein Lipid Oxidation Negative Regulation By Host Of Viral Release From Host Cell Cytoplasmic Transport Cellular Homeostasis Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Cyclase Activity Regulation Of Sodium Ion Transport Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Tagcloud ?		a4 antitrypsin apoa apoc apof apoh apoj apol apolipoproteins apom atherogenic carry chd convincingly delipidation dense differs fibrinogen ldl lysosome originate paraoxonase prenylcysteine proteome sdldl strengthens subfractions transthyretin vldl	abolished acetate acidic akts473 beta1 canonical consistently disruption ffat homolog homology hyperphosphorylated integrin interacting mechanistic motif myristate orp3 oxysterol phenylalanines phorbol pleckstrin pm pma ras requirements selectively stimulate subcellular
Tagcloud (Difference) ?		a4 antitrypsin apoa apoc apof apoh apoj apol apolipoproteins apom atherogenic carry chd convincingly delipidation dense differs fibrinogen ldl lysosome originate paraoxonase prenylcysteine proteome sdldl strengthens subfractions transthyretin vldl	abolished acetate acidic akts473 beta1 canonical consistently disruption ffat homolog homology hyperphosphorylated integrin interacting mechanistic motif myristate orp3 oxysterol phenylalanines phorbol pleckstrin pm pma ras requirements selectively stimulate subcellular
Tagcloud (Intersection) ?